Fetal Liver Organ Cultures as a Tool to Study Selection Processes During B Cell Development

  • R. Ceredig
  • A. G. Rolink
  • F. Melchers
  • J. Andersson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 246)

Abstract

Recent studies concerning B cell development in the mouse embryo have indicated that the first cells committed to the B cell lineage arise in the para-aortic splanchnopleura at a time prior to the hematopoietic colonisation of the fetal liver [1]. The B lymphoid potential of such cells was revealed by in vivo transfer experiments, and has recently been confirmed by analysis in vitro [2]. Whether and in what way the mature B cell progeny of such progenitors contribute to the B cell repertoire in the developing embryo is less clear. This also raises the question of the quantitative and qualitative contribution of splanchnopleura and fetal liver-derived cells to the pool of developing B cells.

Keywords

Titration Sorting FITC Deoxyguanosine Transferase 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • R. Ceredig
    • 1
    • 2
  • A. G. Rolink
    • 1
  • F. Melchers
    • 1
  • J. Andersson
    • 1
  1. 1.The Basel Institute for ImmunologyBaselSwitzerland
  2. 2.Université Louis PasteurStrasbourgFrance

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