Skip to main content
SpringerLink
Log in

A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids

  • Conference paper
Book cover Mechanisms of B Cell Neoplasia 1998

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 246))

Abstract

Among the functionally very heterogeneous G protein-coupled receptors (GPCR) the EDG (endothelial differentiation gene) proteins define a new class of seven transmembrane proteins. The founding member, EDG1, was isolated as a PMA- inducible immediate-early transcript from human umbilical vein endothelial cells (HUVEC) [1]. Up to now six receptors belonging to the EDG family have been identified (see Table 1). As is typical for GPCRs, EDG receptors share the closest similarities in the sequences encompassing the transmembrane domain 1 (TM1) through TM7. Apart from this, EDG receptors are characterized by distinct sequence features such as a GWN/HC tetrapeptide found at the end of TM4. Furthermore all EDG proteins lack a cysteine residue in the first extracellular loop which is usually part of a disulphide bridge in GPCRs [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hla T, Maciag T (1990) An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J Biol Chem 265: 9308 – 9313

    PubMed  CAS  Google Scholar 

  2. Graler MH, Bernhardt G, Lipp M (1998) EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. Genomics 53 (2): 164 – 169

    Article  PubMed  CAS  Google Scholar 

  3. Sakai T, Peyruchaud O, Fässler R, Mosher DF (1998) Restoration of beta 1A integrins is required for lysophosphatidic acid-induced migration of betal-null mouse fibroblastic cells. J Biol Chem 273: 19378 – 19382

    Article  PubMed  CAS  Google Scholar 

  4. . Zhou D, Luini W, Bernasconi S, Diomede L, Salmona M, Mantovani A, Sozzani S (1995) Phosphatidic acid and lysophosphatidic acid induce haptotactic migration of human monocytes. J Biol Chem 270: 25549 – 25556

    Article  PubMed  CAS  Google Scholar 

  5. Sakata Kaneko S, Wakatsuki Y, Usui T, Matsunaga Y, Itoh T, Nishi E, Kume N, Kita T (1998) Lysophosphatidylcholine upregulates CD40 ligand expression in newly activated human CD4+ T cells. FEBS Lett 433: 161 – 165

    Article  Google Scholar 

  6. Moolenaar WH (1991) Mitogenic action of lysophosphatidic acid. Adv Cancer Res 57: 87 – 102

    Article  PubMed  CAS  Google Scholar 

  7. Takada Y, Kato C, Kondo S, Korenaga R, Ando J (1997) Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress. Biochem Biophys Res Commun 240: 737 – 741

    Article  PubMed  CAS  Google Scholar 

  8. Hecht JH, Weiner J A, Post SR, Chun J (1996) Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 135: 1071 – 1083

    Article  PubMed  CAS  Google Scholar 

  9. Allard J, Barron S, Diaz J, Lubetzki C, Zalc B, Schwartz JC, Sokoloff P (1998) A rat G protein-coupled receptor selectively expressed in myelin-forming cells. Eur J Neuroscience 10 (3): 1045 – 1053

    Article  CAS  Google Scholar 

  10. Fukushima N, Kimura Y, Chun J (1998) A single receptor encoded by vzg-l/lp(Al)/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc Natl Acad Sci USA 95 (11): 6151 – 6156

    Article  PubMed  CAS  Google Scholar 

  11. . Weiner JA, Hecht JH, Chun J (1998) Lysophosphatidic acid receptor gene vzg-l/lp(Al)/edg- 2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J Comp Neurol 398 (4): 587 – 598

    Article  PubMed  CAS  Google Scholar 

  12. MacLennan AJ, Marks L, Gaskin AA, Lee N (1997) Embryonic expression pattern of H218, a G-protein coupled receptor homolog, suggests roles in early mammalian nervous system development. Neuroscience 79: 217 – 224

    Article  PubMed  CAS  Google Scholar 

  13. Li Y, MacLennan AJ, Rogers MB (1998) A putative G-protein-coupled receptor, H218, is down-regulated during the retinoic acid-induced differentiation of F9 embryonal carcinoma cells. Exp Cell Res 239: 320 – 325

    Article  PubMed  CAS  Google Scholar 

  14. Liu CH, Hla T (1997) The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics 43: 15 – 24

    Article  PubMed  CAS  Google Scholar 

  15. Rhodes CH, Call KM, Budarf ML, Barnoski BL, Bell CJ, Emanuel BS, Bigner SH, Park JP, Mohandas TK (1997) Molecular studies of an ependymoma-associated constitutional t(l;22)(p22;qll.2). Cytogenet Cell Genet 78: 247 – 252

    Article  PubMed  CAS  Google Scholar 

  16. Lee MJ, Thangada S, Liu CH, Thompson BD, Hla T (1998) Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J Biol Chem 273 (34): 22105 – 22112

    Article  PubMed  CAS  Google Scholar 

  17. Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, Spiegel S, Hla T (1998) Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1. Science 279: 1552 – 1555

    Article  PubMed  CAS  Google Scholar 

  18. An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (1997) Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. Biochem Biophys Res Commun 231: 619 – 622

    Article  PubMed  CAS  Google Scholar 

  19. An S, Bleu T, Hallmark OG, Goetzl EJ (1998) Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 273: 7906 – 7910

    Article  PubMed  CAS  Google Scholar 

  20. . An SZ, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ (1997) Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett 417: 279 – 282

    Article  PubMed  CAS  Google Scholar 

  21. Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996) Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. Biochem Biophys Res Commun 227: 608 – 614

    Article  PubMed  CAS  Google Scholar 

  22. Okazaki H, Ishizaka N, Sakurai T, Kurokawa K, Goto K, Kumada M, Takuwa Y (1993) Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system. Biochem Biophys Res Commun 190: 1104 – 1109

    Article  PubMed  CAS  Google Scholar 

  23. . Jedlicka AE, Taylor EW, Meyers DA, Liu Z, Levitt RC (1994) Localization of the highly polymorphic locus D19S120 to 19pl3.3 by linkage. Cytogenet Cell Genet 65: 140

    Article  PubMed  CAS  Google Scholar 

  24. Risinger JI, Berchuck A, Kohler MF, Watson P, Lynch HT, Boyd J (1993) Genetic instability of microsatellites in endometrial carcinoma. Cancer Res 53: 5100 – 5103

    PubMed  CAS  Google Scholar 

  25. Pykett MJ, Murphy M, Harnish PR, George DL (1994) Identification of a microsatellite instability phenotype in meningiomas. Cancer Res 54: 6340 – 6343

    PubMed  CAS  Google Scholar 

  26. . Pfeilstocker M, Karlic H, Salamon J, Kromer E, Miihlberger H, Pavlova B, Selim U, Tuchler H, Fritsch G, Kneissl S, Heinz R, Pitterman E, Paukovits MR (1996) Expression of G alpha 16, a G-protein alpha subunit specific for hematopoiesis in acute leukemia. Leukemia 10: 1117 – 1121

    PubMed  CAS  Google Scholar 

  27. Amatruda TT, Steele DA, Slepak VZ, Simon MI (1991) G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. Proc Natl Acad Sci USA 88: 5587 – 5591

    Article  PubMed  CAS  Google Scholar 

  28. . Mapara MY, Bommert K, Bargou RC, Leng C, Beck C, Ludwig WD, Gierschik P, Dörken B (1995) G protein subunit G alpha 16 expression is restricted to progenitor B cells during human B-cell differentiation. Blood 85: 1836 – 1842

    PubMed  CAS  Google Scholar 

  29. Emrich T, Förster R, Lipp M (1993) Topological characterization of the lymphoid-specific seven transmembrane receptor BLR1 by epitope-tagging and high level expression. Biochem Biophys Res Commun 197: 214 – 220

    Article  PubMed  CAS  Google Scholar 

  30. Elbe A, Schleischitz S, Strunk D, Stingl G (1994) Fetal skin-derived MHC class I+, MHC class II- dendritic cells stimulate MHC class I-restricted responses of unprimed CD8+ T cells. J Immunol 153: 2878 – 2889

    PubMed  CAS  Google Scholar 

  31. Föster R, Mattis EA, Kremmer E, Wolf E, Brem G, Lipp M (1996) A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87: 1037 – 1047

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Tumor- and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13092, Berlin, Germany

    Markus H. Gräler, Günter Bernhardt & Martin Lipp

Authors
  1. Markus H. Gräler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Günter Bernhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Martin Lipp
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstr. 487, Postfach, CH-4005, Basel, Switzerland

    Fritz Melchers Ph.D.

  2. Laboratory of Genetics Building 37, Room 2B04, National Cancer Institute National Institutes of Health, 37 Convent Drive MSC4255, Bethesda, 20892-4255, MD, USA

    Michael Potter M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Gräler, M.H., Bernhardt, G., Lipp, M. (1999). A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids. In: Melchers, F., Potter, M. (eds) Mechanisms of B Cell Neoplasia 1998. Current Topics in Microbiology and Immunology, vol 246. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60162-0_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60162-0_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64283-8

  • Online ISBN: 978-3-642-60162-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation