Advertisement

A Novel CC Chemokine ABCD-1, Produced by Dendritic Cells and Activated B Cells, Exclusively Attracts Activated T Lymphocytes

  • C. Schaniel
  • F. Sallusto
  • P. Sideras
  • F. Melchers
  • A. G. Rolink
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 246)

Abstract

Cells of the immune system can migrate as single cells through blood and lymph and can organize themselves to form specific areas in primary and secondary lymphoid organs. It has become evident that chemokines and their G protein-coupled seven-transmembrane receptors play an important role in the congregation of lymphoid cells and in the reactions of T and B cells which lead to the formation of germinal centers.

Keywords

Chemokine Receptor Germinal Center Follicular Dendrite Cell Secondary Lymphoid Organ Immature Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    . Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H (1994) The immune response in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1: 167 – 178PubMedCrossRefGoogle Scholar
  2. 2.
    . Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (1998) A B-cell homing chemokine made in lymphoid follicles activates Burkitt’s lymphoma receptor-1. Science 391: 799 – 803Google Scholar
  3. 3.
    . Legler DF, Loetscher M, Ross RS, Clark-Lewis I, Baggiolini M, Moser B (1998) B cell- attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187: 655 – 660PubMedCrossRefGoogle Scholar
  4. 4.
    . Forster R, Mattis AE, Kremmer A, Wolf E, Brem G, Lipp M (1996) A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87: 1037 – 1047PubMedCrossRefGoogle Scholar
  5. 5.
    . Adema GJ, Hartgers F, Verstraten R, de Vries E, Marland G, Menon S, Foster J, Xu Y, Nooyen P, McClanahan T, Bacon KB, Figdor CG (1998) A dendritic-cell-derived CC chemokine that preferentially attracts naive T cells. Nature 387: 713 – 717CrossRefGoogle Scholar
  6. 6.
    . Ngo VN, Tang HL, Cyster JG (1998) Epstain-Barr Virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med 188: 181 – 191PubMedCrossRefGoogle Scholar
  7. 7.
    . Schaniel C, Pardali E, Sallusto F, Speletas M, Ruedl C, Shimizu T, Seidl T, Andersson J, Melchers F, Rolink AG, Sideras P (1998) Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J Exp Med 188: 451 – 463PubMedCrossRefGoogle Scholar
  8. 8.
    . Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (1997) Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J Exp Med 185: 1595 – 1604PubMedCrossRefGoogle Scholar
  9. 9.
    . Chang M, McNinch J, Elias III C, Manthey CL, Grosshans D, Meng T, Boone T, Andrew DP (1997) Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1), that specifically acts on activated T lymphocytes. J Biol Chem 272: 25229 – 25237PubMedCrossRefGoogle Scholar
  10. 10.
    . Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (1998) Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J Biol Chem 273: 1764 – 1768PubMedCrossRefGoogle Scholar
  11. 11.
    . Bonecchi R, Bianchi G, Bordignon PP, D’Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Thls) and Th2s. J Exp Med 187: 129 – 134PubMedCrossRefGoogle Scholar
  12. 12.
    . Sallusto F, Lenig D, Mackay CR, Lanzavecchia A (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 187: 875 – 883PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • C. Schaniel
    • 1
  • F. Sallusto
    • 1
  • P. Sideras
    • 2
  • F. Melchers
    • 1
  • A. G. Rolink
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland
  2. 2.Department of Applied Cell and Molecular BiologyDivision of Tumour Biology, Umeå UniversityUmeåSweden

Personalised recommendations