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Strahlentherapie der pelvinen Lymphabflußwege bei lokal fortgeschrittenem Prostatakarzinom (T2b-T4 NO) ohne und bei lokoregionär fortgeschrittenem Prostatakarzinom (Tx N+) mit Lymphknotenmetastasen

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Prostatakarzinom — urologische und strahlentherapeutische Aspekte

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Zusammenfassung

Kaum eine Frage bewegt die Gemüter der Strahlentherapeuten so kontrovers wie die der Bestrahlung der Lymphabflußwege (LAW) des Beckens bei Patienten mit Prostatakarzinom (PCA) sowohl bei nachgewiesenem als auch bei vermutetem Befall. Es fehlen gesicherte Daten. Die randomisierten Studien der RTOG, die diese Frage teilweise klären sollten, wurden in den 70er Jahren unter heute nicht mehr akzeptierter diagnostischer und strahlentherapeutischer Technik geplant und durchgeführt. Bei zunehmender Zahl von Patienten, die mit PCA zur Bestrahlung vorgestellt werden, müssen sich die Strahlentherapeuten vermehrt dieser Frage stellen.

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Literatur

  1. Anscher MS, Prosnitz LR (1992) Prognostic significance of extent of nodal involvement in stage DI prostate cancer treated with radiotherapy. Urology 39: 39–43.

    Article  PubMed  CAS  Google Scholar 

  2. Asbell SO, Krall JM, Pilepich MV et al. (1988) Elective pelvic irradiation in stage A2, B carcinoma of the prostate: analysis of RTOG 77–06. Int J Radiat Oncol Biol Phys 15: 1307–1316.

    Article  PubMed  CAS  Google Scholar 

  3. Bagshaw MA (1984) Radiotherapeutic treatment of prostatic carcinoma with pelvic node involvement. Urol Clin North Am 11: 297–304.

    PubMed  CAS  Google Scholar 

  4. Batata MA, Hilaris BS, Chu FC et al. (1980) Radiation therapy in adenocarcinoma of the prostate with pelvic lymph node involvement on lymphadenectomy. Int J Radiat Oncol Biol Phys 6:149–153.

    Article  PubMed  CAS  Google Scholar 

  5. Brausi M, Soloway M (1989) Progression and complications after external beam radiation therapy for carcinoma of the prostate. Urology 34:115–119.

    Article  PubMed  CAS  Google Scholar 

  6. Bressel M (1990) Radical prostatectomy-indication, surgical technique, results. Akt Urol (Suppl I): 115–119.

    Google Scholar 

  7. Cheng CW, Bergstrahl EJ, Zincke H (1993) Stage Di prostate cancer. A nonrandomized comparison of conservative treatment options vs. radical prostatectomy. Cancer 71 (Suppl): 996–1004.

    CAS  Google Scholar 

  8. DeKernion J, Huang MY, Kaufman JJ, Smith RB (1985) Results of treatment of patients with stage Di prostatic carcinoma. Urology 26: 446–451.

    Article  PubMed  CAS  Google Scholar 

  9. Dinges S, Budach V (1996) Therapeutische Optionen für N+(Di) Prostatakarzinom-Patienten. In: Schnoor D, Loening SA, Dinges S, Budach V (Hrsg) Lokal fortgeschrittenes Prostatakarzinom, Podium Urologie Bd 1. Blackwell, Berlin Wien, S 137–146.

    Google Scholar 

  10. Epstein BE, Hanks GE (1993) Radiation therapy techniques and dose selection in the treatment of prostate cancer. Semin Radiat Oncol 3:179–186.

    Article  PubMed  Google Scholar 

  11. Fahlenkamp D, Türk I, Müller W, Winfield HN, Loening SA (1995) Laparascopic pelvic lymphadenectomy: transperitoneal access. In: Fahlenkamp D, Loening SA, Winfield HN (eds) Advances in laparascopic urology. Blackwell Science, Oxford, pp 65–70.

    Google Scholar 

  12. Freeman JA, Lieskovsky G, Grossfeld G et al. (1994) Adjuvant radiation, chemotherapy, and androgen deprivation therapy for pathologic stage Di adenocarcinoma of the prostate. Urology 44: 719–724.

    Article  PubMed  CAS  Google Scholar 

  13. Golimbu M, Provet J, Al-Askari S, Morales P (1987) Radical prostatectomy for stage Di prostate cancer. Urology 30: 427–435.

    Article  PubMed  CAS  Google Scholar 

  14. Hanks GE (1993) The challenge of treating node positive prostate cancer. Cancer 71 (Suppl): 1014–1018.

    Article  PubMed  CAS  Google Scholar 

  15. Hanks GE, Diamond JJ, Krall JM (1987) A ten year follow up of 682 patients treated for prostate cancer with radiation therapy in the United States. Int J Radiat Biol Phys 13: 499–505.

    Article  CAS  Google Scholar 

  16. Hanks GE, Schultheiss TE, Hunt MA (1994) Factors influencing the incidence of acute grade II morbidity in conformal and standard treatment of prostate cancer. Int J Radiat Biol Oncol Phys 31: 25–29.

    Article  Google Scholar 

  17. Heipap B, Boeking H, Dohm AG et al. (1985) Klassifikation, histologisches und zytologisches Grading sowie Regressionsgrading des Prostatakarzinoms. Pathologe 6: 3–7.

    Google Scholar 

  18. Klan R, Dieckmann KP, Meier T, Handtke A (1994) Laparaskopische vs. offen chirurgische Lymphadenektomie beim Prostatakarzinom. Urologe A 33:128–133.

    PubMed  CAS  Google Scholar 

  19. Kramer SA, Cline WA, Farnham R et al. (1981) Prognosis of patients with stage Di prostatic adenocarcinoma. J Urol 125: 817–819.

    PubMed  CAS  Google Scholar 

  20. Lawton CA, Won M, Pilepich M et al. (1991) Long-term treatment sequelae following external beam irradiation for adenocarcinoma of the prostate: analysis of RTOG-studies 75–06 and 77–06. Int J Radiat Oncol Biol Phys 21: 935–939.

    Article  PubMed  CAS  Google Scholar 

  21. Lawton CA, Cox JD, Glisch C et al. (1992) Is longterm survival possible with external beam irradiation for stage Di adenocarcinoma of the prostate? Cancer 69: 2761–2766.

    Article  PubMed  CAS  Google Scholar 

  22. Lawton CA, Winter K, Byhardt R et al. (1997) Androgen Suppression plus radiation vs. radiation alone for patients with Di: (pN*) adenocarcinoma of the prostate: (results based on a national prospective randomized trial, RTOG 85–31). Int J Radiat Oncol Biol Phys 38: 931–939.

    Article  PubMed  CAS  Google Scholar 

  23. Leibel SA, Fuks Z, Zelefsky MJ, Whitmore WF (1994) The effect of local and regional treatment on the metastatic outcome. Int J Radiat Oncol Biol Phys 28: 7–16.

    Article  PubMed  CAS  Google Scholar 

  24. Maffezzini M, Carmignani G, Perachino M et al. (1995) Benefits and complications of laparascopic pelvic lymphadenectomy for detection of stage Di prostate cancer: a multicenter experience. Eur Urol 27:135–137.

    PubMed  CAS  Google Scholar 

  25. Mc Gowan DG (1981) The value of extended field radiation therapy in carcinoma of the prostate. Int J Radiat Oncol Biol Phys 7:1333–1339.

    Article  PubMed  CAS  Google Scholar 

  26. Morgan WR, Bergstrahl EJ, Zincke H (1993) Long-term evaluation of radical prostatectomy as treatment for clinical stage C: (T3) prostate cancer. Urology 41:116–120.

    Article  Google Scholar 

  27. Partin AW, Yoo J, Carter HB et al. (1993) The use of PSA, clinical stage, and Gleason score to predict pathological stage in men with localized prostate cancer. J Urol 150:110–114.

    PubMed  CAS  Google Scholar 

  28. Paulson DF, Cline WA, Koefoot RP et al., and Uro-Oncology Research Group (1982) Extended field radiation therapy vs. delayed hormonal therapy in node positive prostatic adenocarcinoma. J Urol 127: 935–937.

    PubMed  CAS  Google Scholar 

  29. Perez CA, Michalski J, Brown KC, Lockett MA (1996) Non randomized evaluation of pelvic lymph node irradiation in localized carcinoma of the prostate. Int J Radiat Oncol Biol Phys 36: 573–584.

    Article  PubMed  CAS  Google Scholar 

  30. Petros JA, Catalona WJ (1992) Lower incidence of unsuspected lymph node metastases in 521 consecutive patients with clinically localized prostate cancer. J Urol 147:147–153.

    Google Scholar 

  31. Pilepich MV, Krall JM, Sause WT et al. (1987) Correlation of radio-therapeutic parameters and treatment related morbidity in carcinoma of the prostate — analysis of RTOG-study 75–06. Int J Radiat Biol Oncol Phys 13: 351–357.

    Article  CAS  Google Scholar 

  32. Ploysongsang SS, Aron BS, Shehata WM (1992) Radiation therapy in prostate cancer: whole pelvis with prostate boost or small field to prostate? Urology 40:18–26.

    Article  PubMed  CAS  Google Scholar 

  33. Sandler HM, Ohl DA, Quint LE, Bree RL (1993) Determing local-regional extension of prostate cancer. Semin Radiat Oncol 3:169–178.

    Article  PubMed  Google Scholar 

  34. Sands ME, Pollak A, Zagars GK (1995) Influence of radiotherapy on node positive prostate cancer treated with androgen ablation: (see comments). Int J Radiat Oncol Biol Phys 31:13–19.

    Article  PubMed  CAS  Google Scholar 

  35. Schmidt JD, Gibbons RP, Murphy GP, Batolucci A (1993) Adjuvant therapy for localized prostate cancer. Cancer 71 (Suppl):1005–1014.

    Article  PubMed  CAS  Google Scholar 

  36. Schuessller WW, Vancaille TG, Reich H, Griffith DP (1991) Transperitoneal endosurgical lymphadenectomy in patients with localized prostate cancer. J Urol 145: 988–994.

    Google Scholar 

  37. Schultheiss TE, Hanks GE, Hunt MA, Lee WR (1995) Incidence of and factors related to late complications in conformal and conventional radiation treatment of cancer of the prostate. Int J Radiat Oncol Biol Phys 32: 643–649.

    Article  PubMed  CAS  Google Scholar 

  38. Schultheiss TE, Lee WR, Hunt MA et al. (1997) Late GI and GU complications in the treatment of prostate cancer. Int J Radiat Oncol Biol Phys 37: 3–11.

    Article  PubMed  CAS  Google Scholar 

  39. Smith JA, Middleton RG (1985) Implications of volume of nodal metastases in patients with adenocarcinoma of the prostate. J Urol 133: 617–619.

    PubMed  Google Scholar 

  40. Steinberg GD, Epstein J.I, Piantadosi S, Walsh PC (1990) Management of stage Di adenocarcinoma of the prostate: The Johns Hopkins experience 1974–1987. J Urol 144:1425–1432.

    PubMed  CAS  Google Scholar 

  41. Wiegel T, Bressel M (1994) Outcome of patients with stage Di prostate cancer — influence of the extent of nodal involvement. Radiat Oncol Invest 2:144–151.

    Article  Google Scholar 

  42. Wiegel T, Bressel M (1995) Regarding Sands et al: Influence of radiotherapy on node-positive prostate cancer treated with androgen ablation. Letter to the editor. Int J Radiat Oncol Biol Phys 32: 896–897.

    PubMed  CAS  Google Scholar 

  43. Wiegel T, Bressel M, Schmidt R (1994) Stage Di prostatic cancer — equivalent results with radiotherapy and hormonal therapy vs. radical prostatectomy, radiotherapy and hormonal therapy: (?) Onkologie 17: 586–593.

    Article  Google Scholar 

  44. Whittington R, Malkowicz SB, Machtay M et al. (1997) The use of combined radiation therapy and hormonal therapy in the management of lymph-node positive prostate cancer. Int J Radiat Oncol Biol Phys 39: 673–680.

    Article  PubMed  CAS  Google Scholar 

  45. Wolf JS, Shinohara K, Carroll PR, Narayan P (1993) Combined role of transrectal ultrasonography, Gleason-Score and PSA in predicting organ confined prostate cancer. Urology 42:131–137.

    PubMed  Google Scholar 

  46. Zietman AL, Shipley WU (1993) Randomized trials in loco regionlly confined prostate cancer: past, present and future. Semin Radiat Oncol 3: 210–220.

    Article  PubMed  Google Scholar 

  47. Zincke H (1990) Combined surgery and immediate adjuvant hormonal treatment for stage Di adenocarcinoma of the prostate: Mayo Clinic experience. Semin Urol 8:175–183.

    PubMed  CAS  Google Scholar 

  48. Zincke H, Utz DC, Thule PM, Taylor WF (1987) Treatment options for patients with stage Di: (T0–3, N1–2, Mo) adenocarcinoma of the prostate. Urology 30: 307–315.

    Article  PubMed  CAS  Google Scholar 

  49. Zincke H, Oesterling JE, Blute ML et al. (1994) Long-term: (15 years) results after radical prostatectomy for clinically localized: (stage T2C or lower) prostate cancer. J Urol 152:1850–1857.

    PubMed  CAS  Google Scholar 

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Authors
  1. T. Wiegel
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  2. S. T. Hoecht
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© 1999 Springer-Verlag Berlin Heidelberg

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Wiegel, T., Hoecht, S.T. (1999). Strahlentherapie der pelvinen Lymphabflußwege bei lokal fortgeschrittenem Prostatakarzinom (T2b-T4 NO) ohne und bei lokoregionär fortgeschrittenem Prostatakarzinom (Tx N+) mit Lymphknotenmetastasen. In: Prostatakarzinom — urologische und strahlentherapeutische Aspekte. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60064-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-60064-7_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64241-8

  • Online ISBN: 978-3-642-60064-7

  • eBook Packages: Springer Book Archive

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