PET and Radiotherapy

  • Val J. Lowe


In the late 1800’s radioactivity and x-rays were discovered. The uses of radioactive treatment developed over the subsequent years and in the early 1900’s some of the standard radiotherapy principles were devised. Experimentation led to the law of Bergonie and Tribondeau which states that radiosensitivity is highest in tissues with a high mitotic index. Other scientists from this time described the dependence of radiation response to oxygen. Further advancement in radiation production equipment and computer assisted treatment planning then occurred. This brought us the radiotherapy practice of today that can provide the generation of controlled radiation doses and radiation delivery to precise tissue areas that optimizes desired radiation dosing.


Diation Therapy Standardize Uptake Ratio Radiation Therapy Normal Tissue Radiotherapy Practice Pretreatment Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brun E, Ohlsson T, Erlandsson K, et al. Early prediction of treatment outcome in head and neck cancer with 2–18FDG PET. Acta Oncologica 1997; 36:741–7PubMedCrossRefGoogle Scholar
  2. Frank A, Lefkowitz D, Jaeger S, et al. Decision logic for re-treatment of asymptomatic lung cancer recurrence based on positron emission tomography findings. Inter J Radiat Oncol Biol Physics 1995; 32:1495–512.CrossRefGoogle Scholar
  3. Greven KM, Williams D3, Keyes JJ, et al. Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation [see comments]. Cancer 1994; 74:1355–9PubMedCrossRefGoogle Scholar
  4. Hall EJ, Cox JD. Physical and biologic basis of radiation therapy. In: Cox JD, ed. Moss’ Radiation Oncology. St. Louis: Mosby-Year Book, Inc, 1994: 3–66Google Scholar
  5. Hautzel H, Muller GH. Early changes in fluorine-18-FDG uptake during radiotherapy. J Nuc Med 1997; 38:1384–6Google Scholar
  6. Hebert ME, Lowe VJ, Hoffman JM, Patz EF, Anscher MS. Positron emission tomography in the pretreatment evaluation and follow-up of non-small cell lung cancer patients treated with radiotherapy: preliminary findings. Amer J Clin Oncol 1996; 19:416–21CrossRefGoogle Scholar
  7. Hughes SW, Sofat A, Kitchen ND, et al. Computer planning of stereotactic iodine-125 seed brachytherapy for recurrent malignant gliomas. Brit J Radiology 1995; 68:175–81CrossRefGoogle Scholar
  8. Ichiya Y, Kuwabara Y, Otsuka M, et al. Assessment of response to cancer therapy using fluorine-18-fluorodeoxy-glucose and positron emission tomography. J Nucl Med 1991;32:1655–60PubMedGoogle Scholar
  9. Inoue T, Kim EE, Komaki R, et al. Detecting recurrent or residual lung cancer with FDG-PET. J Nucl Med 1995;36:788–93PubMedGoogle Scholar
  10. Jones DN, McCowage GB, Sostman HD, et al. Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET. J Nucl Med 1996;37:1438–44PubMedGoogle Scholar
  11. Kiffer JD, Berlangieri SU, Scott AM, et al. The contribution of 18F-fluoro-2-deoxy-glucose positron emission tomographic imaging toradiotherapy planning in lung cancer. Lung Cancer 1998; 19:167–77PubMedCrossRefGoogle Scholar
  12. Koh WJ, Bergman KS, Rasey JS, et al. Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography. Inter J Radiât Oncol Biol Physics 1995; 33:391–8CrossRefGoogle Scholar
  13. Lindholm P, Leskinen KS, Grenman R, et al. Evaluation of response to radiotherapy in head and neck cancer by positron emission tomography and [11C] methionine. Inter J Radiat Oncol Biol Physics 1995; 32:787–94CrossRefGoogle Scholar
  14. Lowe VJ, Hebert ME, Anscher MS, Coleman RE. Chest Wall FDG Accumulation in Serial FDG-PET Images in Patients Being Treated for Bronchogenic Carcinoma with Radiation. Clin Positron Imag 1998; 1:185–192CrossRefGoogle Scholar
  15. Lowe VJ, Patz EF, Harris L, et al. FDG-PET evaluation of pleural abnormalities. J Nucl Med 1994;535:229PGoogle Scholar
  16. Minn H, Clavo AC, Wahl RL. Influence of hypoxia on tracer accumulation in squamous-cell carcinoma: in vitro evaluation for PET imaging. Nuc Med Biol 1996; 23:941–6CrossRefGoogle Scholar
  17. Minn H, Lapela M, Klemi PJ, et al. Prediction of survival with fluorine-18-fluoro-deoxyglucose and PET in head and neck cancer. J Nucl Med 1997; 38:1907–11PubMedGoogle Scholar
  18. Patz EJ, Lowe VJ, Hoffman JM, Paine SS, Harris LK, Goodman PC. Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose. Radiology 1994; 191:379–82.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Val J. Lowe

There are no affiliations available

Personalised recommendations