In the late 1800’s radioactivity and x-rays were discovered. The uses of radioactive treatment developed over the subsequent years and in the early 1900’s some of the standard radiotherapy principles were devised. Experimentation led to the law of Bergonie and Tribondeau which states that radiosensitivity is highest in tissues with a high mitotic index. Other scientists from this time described the dependence of radiation response to oxygen. Further advancement in radiation production equipment and computer assisted treatment planning then occurred. This brought us the radiotherapy practice of today that can provide the generation of controlled radiation doses and radiation delivery to precise tissue areas that optimizes desired radiation dosing.
KeywordsToxicity Hydroxyl Shrinkage Oncol Sarcoma
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