Skip to main content

Radiopharmaceutical Technology, Toxicity and Radiation Dosages

  • Chapter
PET in Oncology
  • 216 Accesses

Abstract

2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG) is the most frequently used PET radiopharmaceutical in Europe with more than 200 doses administered per week (Meyer et al. 1995). Studies described in the literature were performed with different 2-[18F]FDG preparations, but the preparations do not differ significantly from one another. The differences are insignificant for the purpose of evaluating clinical data.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baudot P, Jaque M, Robin M (1977) Effect of a diazo-polyoxamacroobicyclic complexing agent on the urinary elimination of lead in lead-poisened rats. Toxicol Appl Pharmacol 41: 113–115

    Article  PubMed  CAS  Google Scholar 

  • Baumann M, Schäfer E, Grein H (1984) Short term studies with the cryptating agent hexaoxa-diaza-bicyclo-hexacosane in rats. Arch Toxicol 55 [Suppl 7]: 427–429

    Google Scholar 

  • Dowd MT, Chin-Tu C, Wendel MJ, Faulhaber PJ, Cooper MD (1991) Radiation dose to the bladder wall from 2-(l8F) fluoro-2-desoxy-D-glucose in adult humans. J Nucl Med 32: 707–712

    PubMed  CAS  Google Scholar 

  • European Pharmacopoeia (1996) Radiopharmaceutical preparations, pp 1424–1433

    Google Scholar 

  • Gallagher BM, Ansari A, Atkins H et al. (1977) Radiopharmaceuticals XXVII. 18F-labeled 2-desoxy-2-fluoro-D-glu-cose as a radiopharmaceutical for measuring regional myocardial glucose metabolism in vivo: tissue distribution and imaging studies in animals. J Nucl Med 18: 990–996

    PubMed  CAS  Google Scholar 

  • Gallagher BM, Fowler JS, Gutterson NI, MacGregor RR, Wan CN, Wolf AP (1978). Metabolic trapping as a principle of radiopharmaceutical design: some factors responsible for the biodistribution of 2-Deoxy-2-[18F]fluoro-D-glucose. J Nucl Med 19: 1154–1161

    PubMed  CAS  Google Scholar 

  • Hamacher K, Coenen HH, Stöcklin G (1986) Efficient stereo-specific synthesis of no-carrier-added 2-[18F] fluoro-2-deoxy-D-glucose using aminopolyether supported nu-cleophilic substitution. J Nucl Med 27: 235–238

    PubMed  CAS  Google Scholar 

  • Mejia AA, Nakamura T, Mastoshi I, Hatazawa J, Masaki M, Shoichi W (1991) Estimation of absorbed doses in humans due to intravenous administration of fluorine-18F-fluorodeoxyglucose in PET studies. J Nucl Med 32: 699–706

    PubMed  CAS  Google Scholar 

  • Meyer G-J, Coenen HH, Waters SL et al. (1993) Quality assurance and quality control of short-lived radiopharma-ceutikals for PET. In: Stöcklin and Pike (eds) Radiopharmaceuticals for PET. Kluwer, Amsterdam, pp 91–150

    Google Scholar 

  • Meyer GJ, Waters SL, Coenen H H., Luxen A, Maziere B, Langström B (1995) PET radiopharmaceuticals in Europe: current use and data relevant for the formulation of summaries of product characteristics (SPCs). Eur J Nucl Med 22/12: 1420–1432

    Article  PubMed  CAS  Google Scholar 

  • Oehr P, Ruhlmann J, Rink H (1989) 18F-FDG Transport: Abhängigkeit von Glucosekonzentration und Strahlendosis. Nuklearmedizin 37: A68

    Google Scholar 

  • Reivich M, Kuhl D, Wolf A et al. (1979). The [18F] fluorodeox-yglucose method for the measurement of local cerebral glucose utilization in man. Circ Res 44: 127–137

    PubMed  CAS  Google Scholar 

  • Som P, Atkins HL, Bandoypadhyay D, Fowler JS et al. (1980) A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glu-cose (F-18): nontoxic tracer for rapid tumor detection. J Nucl Med 21: 670–675

    PubMed  CAS  Google Scholar 

  • United States Pharmacopeia, USP (1995) Fludeoxyglucose F18 Injections. USP 23: 674

    Google Scholar 

  • Woosley RL, Kim YS, Huang KC (1970) Renal tubular transport of 2-deoxy-D-glucose in dogs and rats. J Pharmacol Exp Ther 173: 13–20

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ruhlmann, J., Oehr, P. (1999). Radiopharmaceutical Technology, Toxicity and Radiation Dosages. In: Ruhlmann, J., Oehr, P., Biersack, HJ. (eds) PET in Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60010-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60010-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64220-3

  • Online ISBN: 978-3-642-60010-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics