Skip to main content

Wirkung von Ballaststoffen, kurzkettigen Fettsäuren und Glutamin auf die Funktion des Dünn- und Dickdarms

  • Chapter
  • 106 Accesses

Zusammenfassung

Traditionell wird der nutritive Aspekt der enteralen Substratzufuhr in den Vordergrund der Betrachtung gestellt. Diese Sichtweise vernachlässigt, daß Inhaltsstoffe der Nahrung Struktur und Funktion des Intestinaltrakts nachhaltig beeinflussen. Beispielhaft sei der trophische Effekt einer enteralen Ernährung auf die Zottenhöhe des Jejunums genannt; die orale Nahrungskarenz führt binnen weniger Tage zur Epithelatrophie. Unter den luminalen „Schlüsselsubstanzen“ scheinen die beim Ballaststoffabbau entstehenden kurzkettigen Fettsäuren für das Kolon und die Aminosäure L-Glutamin für den Dünndarm von besonderer Bedeutung zu sein.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-59960-6_66
  • Chapter length: 5 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   69.99
Price excludes VAT (USA)
  • ISBN: 978-3-642-59960-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   89.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aghdassi E, Plapler H, Kurian R, Raina N, Royall D, Jeejeebhoy KN et al. (1994) Colonic fermentation and nutritional recovery in rats with massive small bowel resection. Gastroenterology 107:637–642

    PubMed  CrossRef  CAS  Google Scholar 

  • Bartram HP, Scheppach W, Heid C, Fabian C, Kasper H (1991) Effect of starch malabsorption on fecal bile acids and neutral sterols in humans: Possible implications for colonic carcinogenesis. Cancer Res 51:4238–4242

    PubMed  CAS  Google Scholar 

  • Bartram HP, Scheppach W, Schmid H, Hofmann A, Dusel G, Richter F et al. (1993) Proliferation of human colonic mucosa as an intermediate biomarker of carcinogenesis: effects of butyrate, deoxycholate, calcium, ammonia, and pH. Cancer Res 53:3283–3288

    PubMed  CAS  Google Scholar 

  • Blackburn NA, Redfern JS, Jarjis H, Holgate AM, Hanning I, Scarpello JHB et al. (1984) The mechanism of action of guar gum in improving glucose tolerance in man. Clin Sci 66:329–336

    PubMed  CAS  Google Scholar 

  • Breuer RI, Soergel KH, Lashner BA, Christ ML, Hanauer SB, Vanaguas A et al. (1997) Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial. Gut 40:485–491

    PubMed  CAS  Google Scholar 

  • Cummings JH, Englyst HN (1991) Measurement of starch fermentation in the human large intestine. Can J Physiol Pharmacol 69:121–129

    PubMed  CrossRef  CAS  Google Scholar 

  • Deng G, Liu G, Hu L, Gum JR, Kim YS (1992) Transcriptional regulation of the human placental-like alkaline phosphatase gene and mechanisms involved in its induction by sodium butyrate. Cancer Res 52:3378–3383

    PubMed  CAS  Google Scholar 

  • Frankel WL, Zhang W, Singh A, Klurfeld DM, Don S, Sakata T et al. (1994) Mediation of the trophic effects of short-chain fatty acids on the rat jejunum and colon. Gastroenterology 106:375–380

    PubMed  CAS  Google Scholar 

  • Garnet L, Daviaud D, Denis-Pouxviel C, Remesy C, Murat J-C (1992) Effects of short-chain fatty acids on growth and differentiation of the human colon cancer cell line HT29. Int J Cancer 52:286–289

    CrossRef  Google Scholar 

  • Hague A, Manning AM, Hanlon KA, Hutschtscha LI, Hart D, Paraskeva C (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int J Cancer 55:498–505

    PubMed  CrossRef  CAS  Google Scholar 

  • Harig JM, Soergel KH, Komorowski RA, Wood CM (1989) Treatment of diversion colitis with short-chain-fatty acid irrigation. N Engl J Med 320:23–28

    PubMed  CrossRef  CAS  Google Scholar 

  • Howe GR, Benito E, Castelleto R, Cornée J, Estève J, Gallagher RP et al. (1992) Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. J Natl Cancer Inst 84:1887–1896

    PubMed  CrossRef  CAS  Google Scholar 

  • Jenkins DJA, Wolever TMS, Taylor RH, Barker H, Fielden H, Baldwin JM et al. (1981) Glycemie index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34:362–366

    PubMed  CAS  Google Scholar 

  • Kruh J, Tichonicky L, Defer N (1994) Effect of butyrate on gene expression. In: Binder HJ, Cummings JH, Soergel KH (Hrsg) Short Chain Fatty Acids. Dordrecht, Kluwer Academic Publishers, pp 135–147

    Google Scholar 

  • Macfarlane GT, Cummings JH (1991) The colonic flora, fermentation, and large bowel digestive function. In: The Large Intestine: Physiology, Pathophysiology, and Disease. Phillips SF, Pemberton JH, Shorter RG (Hrsg) New York, Raven Press, pp 51–91

    Google Scholar 

  • McIntyre A, Gibson PR, Young GP (1993) Butyrate production from dietary fibre and protection against large bowel cancer in a rat model. Gut 34:386–391

    PubMed  CrossRef  CAS  Google Scholar 

  • Potter JD (1992) Reconciling the epidemiology, physiology, and molecular biology of colon cancer. J Am Med Assoc 268:1573–1577

    CrossRef  CAS  Google Scholar 

  • Roediger WEW (1980) Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21:793–798

    PubMed  CrossRef  CAS  Google Scholar 

  • Roediger WEW (1990) The starved colon — diminished mucosal nutrition, diminished absorption, and colitis. Dis Colon Rect 33:858–862

    CrossRef  CAS  Google Scholar 

  • Saini K, Steele G, Thomas P (1990) Induction of carcinoembryonic antigen-gene expression in human colorectal carcinoma by sodium butyrate. Biochem J 272:541–544

    PubMed  CAS  Google Scholar 

  • Scheppach W, Fabian C, Ahrens F, Spengler M, Kasper H (1988) Effect of starch malabsorption on colonic function and metabolism in humans. Gastroenterology 95:1549–1555

    PubMed  CAS  Google Scholar 

  • Scheppach W, Bartram P, Richter A, Richter F, Liepold H, Dusel G et al. (1992) Effect of short-chain fatty acids on the human colonic mucosa in vitro. J Parenter Enteral Nutr 16:43–48

    CrossRef  CAS  Google Scholar 

  • Scheppach W, Sommer H, Kirchner T, Paganelli G-M, Bartram P, Christi S et al. (1992) Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 103:51–56

    PubMed  CAS  Google Scholar 

  • Scheppach W, Loges C, Bartram P, Christi SU, Richter F, Dusel G et al. (1994) Effect of free glutamine and alanylglutamine dipeptide on mucosal proliferation of the human ileum and colon. Gastroenterology 107:429–434

    PubMed  CAS  Google Scholar 

  • Scheppach W, Bartram HP, Richter F (1995) Role of short-chain fatty acids in the prevention of colorectal cancer. Eur J Cancer 31A: 1077–1080

    PubMed  CrossRef  CAS  Google Scholar 

  • Scheppach W, and the German-Austrian SCFA study group (1996) Treatment of distal ulcerative colitis with short-chain fatty acid enemas: A placebo-controlled trial. Dig Dis Sci 41:2254–2259

    PubMed  CrossRef  CAS  Google Scholar 

  • Tremel H, Kienle B, Weilemann LS, Stehle P, Fürst P (1994) Glutamine dipeptide-supplemented parenteral nutrition maintains intestinal function in the critically ill. Gastroenterology 107:1595–1601

    PubMed  CAS  Google Scholar 

  • Van der Hulst RRWJ, van Kreel BK, von Meyenfeldt MF, Brummer RJM, Arends JW, Deutz NEP et al. (1993) Glutamine and the preservation of gut integrity. Lancet 341:1363–1366

    PubMed  CrossRef  Google Scholar 

  • Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. (1988) Genetic alterations during colorectal tumor development. N Engl J Med 319:525–532

    PubMed  CrossRef  CAS  Google Scholar 

  • Weber FL (1979) The effect of lactulose on urea metabolism and nitrogen excretion in cirrhotic patients. Gastroenterology 77:518–523

    PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Scheppach, W. (1999). Wirkung von Ballaststoffen, kurzkettigen Fettsäuren und Glutamin auf die Funktion des Dünn- und Dickdarms. In: Caspary, W.F., Stein, J. (eds) Darmkrankheiten. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59960-6_66

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59960-6_66

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64197-8

  • Online ISBN: 978-3-642-59960-6

  • eBook Packages: Springer Book Archive