Plant Expression Systems for the Production of Vaccines
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Plant biotechnology is a rapidly expanding area, and in the last 5–10 years it has become apparent that plant systems may be particularly valuable for the expression and production of recombinant molecules. A considerable effort has focused on genetic engineering for the improvement of plant characteristics and agricultural properties, but the technology has also been applied to the production of “high-value” products, namely pharmaceutical compounds and vaccines. A particular attraction of this approach is the potential for growing immunotherapeutic reagents on an agricultural scale, thereby significantly reducing the costs of production. However, as this review will attempt to demonstrate, there are many other advantages related to the use of plants. This chapter will review the major advances in plant genetic engineering for the production of products for both active and passive immunisation. It will discuss the advantages and disadvantages of the plant expression systems as well as strategies that have been devised to overcome some of the specific problems.
KeywordsTransgenic Plant Tobacco Mosaic Virus Secretory Component Protein Disulphide Isomerase Tomato Bushy Stunt Virus
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