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Chemoprevention of Cancer pp 71–84Cite as

Prognostic Implications of Cancer Susceptibility Genes: Any News?

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 151))

Abstract

Recent advances in our understanding of the genetic basis of several inherited predispositions to cancer have raised the possibility that there may be differences in prognosis between patients harbouring genetic susceptibilities to cancer and persons presenting with sporadic disease. The two best studied models of inherited susceptibilities to cancer will be considered, those of colorectal cancer and familial breast cancer. Familial colorectal cancer can be subdivided into essentially two groups: familial adenomatous polyposis and hereditary non-polyposis colorectal cancer. Familial breast cancer can be subdivided into three groups: those that can be accounted for by mutations in the breast cancer susceptibility gene BRCA 1, families harbouring mutations in BRCA 2 and families where neither BRCA 1 nor BRCA 2 appear to be involved. In this chapter several aspects of these inherited cancer predispositions will be discussed and compared with their equivalent sporadic disease counterparts.

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Authors and Affiliations

  1. Hunter Area Pathology Service, Locked Bag 1, New Lambton, 2310, New South Wales, Australia

    R. J. Scott

  2. Genetic Oncology Department/INSERM CRI 9703, Institut Jean-Paoli Calmettes, 232, Bd. St. Marguerite, F-13009, Marseille, France

    H. H. Sobol

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  1. R. J. Scott
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  2. H. H. Sobol
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Editors and Affiliations

  1. Center for Tumordetection and Prevention, Rorschacherstrasse 150, CH-9006, St. Gallen, Switzerland

    Hans-Jörg Senn

  2. European Institute of Oncology, Via Ripamonti, I-20141, Milan, Italy

    Alberto Costa M.D.

  3. Robert H. Lurie Cancer Center Breast Cancer Research Program, Olson Pavilion, Northwest-University Medical School, 503 E. Chicago Ave., 60611, Chicago, IL, USA

    V. Craig Jordan

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© 1999 Springer-Verlag Berlin · Heidelberg

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Scott, R.J., Sobol, H.H. (1999). Prognostic Implications of Cancer Susceptibility Genes: Any News?. In: Senn, HJ., Costa, A., Jordan, V.C. (eds) Chemoprevention of Cancer. Recent Results in Cancer Research, vol 151. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59945-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-59945-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64192-3

  • Online ISBN: 978-3-642-59945-3

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