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Brain Imaging in Normal Aging and in Alzheimer’s Disease

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Abstract

Imaging the Alzheimer’s brain as well as the brain of other patients with neurodegenerative diseases is a non-invasive method with the potentials to describe the progression of disease, to understand mechanisms of disease and to evaluate the efficacy of proposed therapies. Below the various methods of imaging are discussed from the viewpoints of how they work and how they have been used or could be used in Alzheimer’s disease (AD). A concise synopsis is given at the end of this chapter for the student and researcher interested in the main conclusions of the 1990’s. More details of the methodologies can be found in a recent chapter (Budinger, 1996) devoted to the study of applications of neuroimaging in AD. This publication is a condensed version of this chapter with new information on functional magnetic resonance imaging (fMRI).

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References

  • Becker JT, Mintun MA, Aleva K, Wiseman MB, Nichols T, Dekosky ST (1996) Alterations in functional neuroanatomical connectivity in Alzheimer’s disease. Positron emission tomography of auditory verbal shortterm memory. Ann NY Acad Sci 777: 239–242

    CAS  Google Scholar 

  • Belliveau JW, Kennedy DNJ, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR (1991) Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254: 716–719

    Article  PubMed  CAS  Google Scholar 

  • Budinger TF (1992) Emerging nuclear magnetic resonance technologies. Health and safety. Annal New York Acad Sci 649: 1–18

    Article  CAS  Google Scholar 

  • Budinger TF (1996) Neuroimaging Applications for the Study of Alzheimer’s disease. In: Alzheimer’s disease: cause(s), diagnosis, treatment, and care, (edited by Khachaturian, ZS and Radebaugh, TS) 146–169, CRC Press, Boca Raton

    Google Scholar 

  • Budinger TF, Derenzo SE, Huesman RH, Jagust WJ, Valk PE (1991) High resolution positron emission tomography for medical science studies. Acta Radiolog Suppl 376:15–23

    CAS  Google Scholar 

  • Budinger TF, Gullberg GT, Huesman RH (1979) Emission computed tomography. In: Topics in Applied Physics: Image Reconstruction from Projections: Implementation and Applications., (edited by Herman GT) 147–246, Springer-Verlag, Berlin

    Google Scholar 

  • de Leon MJ, Ferris SH, George AE, Reisberg B, Kricheff II, Gershon S (1980) Computed tomography evaluations of brain-behavior relationships in senile dementia of the Alzheimer’s type. Neurobiol Aging 1:69–79

    Article  PubMed  Google Scholar 

  • de Leon MJ, Golomb J, George AE, Convit A, Tarshish CY, McRae T, De Santi S, Smith G, Ferris SH, Noz M (1993) The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation. AJNR 14:897–906

    PubMed  Google Scholar 

  • Erkinjuntti T, Lee DH, Gao F, Steenhuis R, Eliasziw M, Fry R, Merskey H, Hachinski VC (1993) Temporal lobe atrophy on magnetic resonance imaging in the diagnosis of early Alzheimer’s disease. Arch Neurol 50:305–310

    PubMed  CAS  Google Scholar 

  • Ford CV, Winter J (1981) Computerized axial tomograms and dementia in elderly patients. J Gerontol 36:164–169

    PubMed  CAS  Google Scholar 

  • Fox PT, Mintun MA, Reiman EM, Raichle ME (1988) Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images. J Cereb Blood Flow Metab 8:642–653

    Article  PubMed  CAS  Google Scholar 

  • Grady CL (1996) Age-related changes in cortical blood flow activation during perception and memory. Ann NY Acad Sci 777:14–21

    Article  PubMed  CAS  Google Scholar 

  • Heiss WD, Kessler J, Slansky I, Mielke R, Szelies B, Herholz K (1993) Activation PET as an instrument to determine therapeutic efficacy in Alzheimer’s disease. Ann NY Acad Sci 695:327–331

    Article  PubMed  CAS  Google Scholar 

  • Huckman MS, Fox J, Topel J (1975) The validity of criteria for the evaluation of cerebral atrophy by computed tomography. Radiology 116:85–92

    PubMed  CAS  Google Scholar 

  • Jack CRJ, Petersen RC, O’Brien PC, Tangalos EG (1992) MR-based hippocampal volumetry in the diagnosis of Alzheimer’s disease. Neurology 42:183–188

    PubMed  Google Scholar 

  • Jacoby RJ, Levy R (1980) Computed tomography in the elderly. 2. Senile dementia: diagnosis and functional impairment. Brit J Psychiat 136:256–269

    Article  PubMed  CAS  Google Scholar 

  • Jagust WJ, Eberling JL, Richardson BC, Reed BR, Baker MG, Nordahl TE, Budinger TF (1993) The cortical topography of temporal lobe hypome-tabolism in early Alzheimer’s disease. Brain Res 629:189–198

    Article  PubMed  CAS  Google Scholar 

  • Katz D, Taubenberger JK, Cannella B, McFarlin DE, Raine CS, McFarland HF (1993) Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Annals of Neurology 34:661–669

    Article  PubMed  CAS  Google Scholar 

  • Kawai M, Cras P, Perry G (1992) Serial reconstruction of beta-protein amyloid plaques: relationship to microvessels and size distribution. Brain Res 592:278–282

    Article  PubMed  CAS  Google Scholar 

  • Kesslak JP, Nalcioglu O, Cotman CW (1991) Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer’s disease [see comments]. Neurology 41:51–54

    PubMed  CAS  Google Scholar 

  • Killiany RJ, Moss MB, Albert MS, Sandor T, Tieman J, Jolesz F (1993) Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer’s disease. Arch Neurol 50:949–954

    PubMed  CAS  Google Scholar 

  • Kuhl DE, Edwards RQ (1963) Image separation radioisotope scanning. Radiology 80:653

    Google Scholar 

  • Lehericy S, Baulac M, Chiras J, Pierot L, Martin N, Pillon B, Deweer B, Dubois B, Marsault C (1994) Amygdalohippocampal MR volume measurements in the early stages of Alzheimer disease. AJNR 15:929–937

    PubMed  CAS  Google Scholar 

  • Menon RS, Ogawa S, Hu X, Strupp JP, Anderson P, Ugurbil K (1995) BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals. Magn Reson Med 33:453–459

    Article  PubMed  CAS  Google Scholar 

  • Mentis MJ, Horwitz B, Grady CL, Alexander GE, VanMeter JW, Maisog JM, Pietrini P, Schapiro MB, Rapoport SI (1996) Visual cortical dysfunction in Alzheimer’s disease evaluated with a temporally graded “stress test” during PET. Am J Psych 153:32–40

    CAS  Google Scholar 

  • Moses WW, Derenzo SE, Budinger TF (1994) PET Detector Modules Based on Novel Detector Technologies. Nuc Instrum Meth Phys Res A 353: 189–194

    Article  CAS  Google Scholar 

  • Ogawa S, Lee TM, Nayak AS, Glynn P (1990) Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Mag Res Med 14:68–78

    Article  CAS  Google Scholar 

  • Pettegrew JW, Panchalingam K, Klunk WE, McClure RJ, Muenz LR (1994) Alterations of cerebral metabolism in probable Alzheimer’s disease: a preliminary study. Neurobiol Aging 15:117–132

    Article  PubMed  CAS  Google Scholar 

  • Roland PE, Eriksson L, Stone-Elander S, Widen L (1987) Does mental activity change the oxidative metabolism of the brain? J Neurosci 7:2373–2389

    PubMed  CAS  Google Scholar 

  • Seab JP, Jagust WJ, Wong ST, Roos MS, Reed BR, Budinger TF (1988) Quantitative NMR measurements of hippocampal atrophy in Alzheimer’s disease. Magn Reson Med 200–208200–208

    Article  Google Scholar 

  • Tsui BM, Zhao X, Frey EC, McCartney WH (1994) Quantitative single-photon emission computed tomography: basics and clinical considerations. Semin Nucl Med 24:38–65

    Article  PubMed  CAS  Google Scholar 

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© 1999 Springer-Verlag Berlin Heidelberg

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Budinger, T.F. (1999). Brain Imaging in Normal Aging and in Alzheimer’s Disease. In: Sternberg, H., Timiras, P.S. (eds) Studies of Aging. Springer Lab Manual. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59916-3_14

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  • DOI: https://doi.org/10.1007/978-3-642-59916-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64600-6

  • Online ISBN: 978-3-642-59916-3

  • eBook Packages: Springer Book Archive

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