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Significant Reduction in Thrombogenicity of Intracoronary Stents by Diamond-Like Carbon Coating

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28. Hämophilie-Symposion Hamburg 1997

Abstract

The application of intracoronary stents improves the clinical results of percutaneous transluminal coronary angioplasty (PTCA) [1]. However, thrombogenicity of metallic stents has proven to be a significant limiting feature in the management of patients undergoing coronary stent placement [2]. Still, acute or subacute occlusion or restenosis occurs in 3%-8% of cases within hours to months [3].

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References

  1. Bittl JA (1997) Advances in coronary angioplasty. N Engl J Med 335: 1290–1302

    Article  Google Scholar 

  2. Roubin GS, King SB, Douglas JS et al. (1990) Intracoronary stenting during percutaneous transluminal angioplasty. Circulation 81: IV-92–IV-100

    Google Scholar 

  3. De Feyter PJ, van den Brand M, Laarman GJ et al. (1993) Acute coronary occlusion during and after percutaneous transluminal coronary angioplasty: frequency, prediction, clinical course, management, and follow-up. Circulation 83: 927–936

    Google Scholar 

  4. Beythien C, Terres W, Hamm CW (1994) In vitro model to test the thrombogenicity of coronary stents. Thromb Res 75: 581–590

    Article  PubMed  CAS  Google Scholar 

  5. Ruf A, Patscheke H (1995) Flow cytometric detection of activated platelets. Comparison of determining shape change, fibrinogen binding and P-selectin expression. Semin Thromb Hemost 21: 150

    Google Scholar 

  6. MacDonald RG, Hendersson MA, Hirshfeld Jj et al. (1990) Patient related variables and restenosis after percutaneous transluminal coronary balloon angioplasty: a report from the M-HEART group. Am J Cardiol 66: 926–931

    Article  PubMed  CAS  Google Scholar 

  7. Serruys PW, Emanuelsson H, van der Giessen W et al. (1996) Heparin-coated Palmaz-Schatz stents in human coronary arteries. Circulation 93: 412–422

    PubMed  CAS  Google Scholar 

  8. Lu L, Jones MW (1993) Diamond-like carbon as biological compatible material for cell culture and medical applications. Biol Med Mater Engin 3: 223–228

    CAS  Google Scholar 

  9. Courtney JM, Lamba NMK, Sundaram S, Forbes CD (1994) Biomaterials for bloodcontacting applications. Biomaterials 15: 737–744

    Article  PubMed  CAS  Google Scholar 

  10. Klein CL et al. (1994) The role of metal corrosium in inflammatory processes: induction of adhesion molecules by heavy metal ions. J Mater Sci Mater Med 5: 798–807

    Article  CAS  Google Scholar 

  11. Majerus PW, Miletich JP (1978) Relationships between platelets and coagulation factors in hemostasis. Annu Rev Med 29: 41–49

    Article  PubMed  CAS  Google Scholar 

  12. Bauer KA, Rosenberg RD (1987) The pathophysiology in the prethrombotic state in humans: insights gained from studies using markers of hemostatic system activation. Blood 70: 343–350

    PubMed  CAS  Google Scholar 

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© 1999 Springer-Verlag Berlin Heidelberg

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Gutensohn, K. et al. (1999). Significant Reduction in Thrombogenicity of Intracoronary Stents by Diamond-Like Carbon Coating. In: Scharrer, I., Schramm, W. (eds) 28. Hämophilie-Symposion Hamburg 1997. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59915-6_74

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  • DOI: https://doi.org/10.1007/978-3-642-59915-6_74

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64581-8

  • Online ISBN: 978-3-642-59915-6

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