Chronic Allograft Nephropathy: The Inevitable Outcome of Renal Transplantation?

  • S. M. Dodd
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 92)

Abstract

Many renal allografts now survive and function for decades, but long-term degenerative remodelling of the transplant (chronic allograft nephropathy), with inexorable decline in renal function, is one of the most important determinants of the ultimate outcome of renal transplantation [86].

Keywords

Cholesterol Migration Ischemia Interferon Luminal 

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References

  1. 1.
    Alexander SR, Arbus GS, Butt KM, Conley S, Fine RN, Greiter I, Gruskin AB, Harmon WE, McEnery PT, Nevins TE, et al. (1990) The 1989 report of North American Pediatric Renal Transplant Cooperative Study. Pediatr Nephrol 4: 542–553.PubMedGoogle Scholar
  2. 2.
    Almond PS, Matas AJ, Gillingham K, Dunn DL, Payne WD, Gores P, Gruessner R, Najarian JS (1993) Risk factors for chronic rejection in renal allograft recipients. Transplantation 55:752–757.PubMedGoogle Scholar
  3. 3.
    Batchelor JR (1980) The immunogenic signal of allografts. Adv Nephrol Necker Hosp 9: 237–244.PubMedGoogle Scholar
  4. 4.
    Baltzan MA, Baltzan RB, Baltzan BL, Cunningham TC, Pylypchnk GB, Dyck RF, West ML (1990) HLA matching enhances long-term renal graft survival but does not relate to acute rejection. Medicine (Baltimore) 64: 227–231.Google Scholar
  5. 5.
    Basadonna GP, Matas AJ, Gillingham KJ, Payne WD, Dunn DL, Sutherland DE, Gores PF, Gruessner RW, Arrazola L, Najarian JS (1993) Relationship between early vs late acute rejection and onset of chronic rejection in kidney transplantation. Transplant Proc 25:910–911.PubMedGoogle Scholar
  6. 6.
    Beck S, Barreil BG (1988) Human cytomegalovirus encodes a glycoprotein homologous to MHC class-antigens. Nature 331: 269–272.PubMedGoogle Scholar
  7. 7.
    Benditt EP, Barrett T, Dougall JK (1983) Viruses in the etiology of atherosclerosis. Proc Natl Acad Sei U S A 80: 6386–6389.Google Scholar
  8. 8.
    Besbas N, Sayed-Ahmed N, Cope GH (1992) Distribution of immunoreactive growth factors in ischemic renal injury. J Am Soc Nephrol 3: 703.Google Scholar
  9. 9.
    Border WA, Nobel NA (1994) Transforming growth factor ß in tissue fibrosis. N Engl J Med 331:1286–1292.PubMedGoogle Scholar
  10. 10.
    Braun MY, McCormack A, Webb G, Batchelor JR (1993) Mediation of acute but not chronic rejection of MHC-incompatible rat kidney grafts by alloreactive CD4 T cells activated by the direct pathway of sensitization. Transplantation 55:177–182.PubMedGoogle Scholar
  11. 11.
    Brenner BM, Meyer TW, Hostetter TH (1982) Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation and intrinsic renal disease. N Engl J Med 11: 652–659.Google Scholar
  12. 12.
    Brewer Y, Palmer A, Taube D, Welsh K, Bewick M, Bindon C, Hale G, Waldmann H, Dische F, Parsons V, et al. (1989) Effect of graft perfusion with two CD45 monoclonal antibodies on the incidence of kidney allograft rejection. Lancet ii: 935–937.Google Scholar
  13. 13.
    Burdick JF, Beschorner WE, Smith WJ, McGraw DJ, Bender WL, Williams GM, SolezK (1984) Characteristics of early routine renal allograft biopsies. Transplantation 38:1058–1067.Google Scholar
  14. 14.
    Busch GJ, Schamberg JF, Morets RL, Strom TB, Tilney NL, Carpenter CB (1976) T and B cell patterns in irreversibly rejected human renal allografts: correlation of morphology with surface markers and cytotoxic capacity of the isolated lymphoid infiltrate. Lab Invest 35: 272–280.PubMedGoogle Scholar
  15. 15.
    Cecka JM (1994) Outcome statistics of renal transplants with an emphasis on long-term survival. Clin Transplant 8: 324–327.PubMedGoogle Scholar
  16. 16.
    Cecka JM, Terasaki PI (1990) Matching kidneys for size in renal transplantation. Clin Transplant 4: 82.Google Scholar
  17. 17.
    Cook DJ, Terazki PI (1989) Renal transplantation in the American continent. In: Brent L, Sells RA (eds) Organ transplantation: current clinical and immunological concepts. Balliere, London, p 195.Google Scholar
  18. 18.
    Cosio FG, Orosz CG (1992) Adhesion molecules and the kidney in health and disease. J Nephrol 6: 22–31.Google Scholar
  19. 19.
    Cramer DV, Qian S, Harnaha J, Chapman FA, Starzl TE, Makowka L (1989) Accelerated graft arteriosclerosis is enhanced by sensitization of the recipients to donor lymphocytes. Transplant Proc 21: 3714–3715.PubMedGoogle Scholar
  20. 20.
    Croker BP, Salomon DR (1989) Pathology of the renal allograft. In: Tisher CC, Brenner BM (eds) Renal pathology with clinical and functional correlations. Lippincott, Philadelphia, pp 1518–1554.Google Scholar
  21. 21.
    D’Ardenne AJ, Dunnill MS, Thompson JF, McWhinnie D, Wood RFM, Morris PJ (1986) Cyclosporin and renal graft histology. J Clin Pathol 39:145–151.PubMedGoogle Scholar
  22. 22.
    DiCorleto PE, Bowen-Pope DF (1983) Cultured endothelial cells produce a platelet-derived growth factor-like protein. Proc Natl Acad Sci U S A 80:1919–1923.PubMedGoogle Scholar
  23. 23.
    Dimeny E, Fellstrom B, Larsson E, Tufveson G, Lithell H (1993a) Hyperlipoproteinaemia in renal transplant recipients — is there a linkage with chronic vascular rejection? Transplant Proc 25: 2065–2066.PubMedGoogle Scholar
  24. 24.
    Dimeny E, Tufveson G, Lithell H, Larsson E, Siegbahn A, Fellstrom B (1993b) The influence of pretransplant lipoprotein abnormalities on early results of renal transplant. Eur J Clin Invest 23: 572–579.PubMedGoogle Scholar
  25. 25.
    Doxiadis UN, Smits JMA, Schreuder GMTh, Persijn GG, van Houwelingen HC, van Rood J J, Claas FHJ (1996) Association between specific HLA combinations and probability of kidney allograft loss: the taboo concept. Lancet 348: 850–853PubMedGoogle Scholar
  26. 26.
    Dummer JS, White LT, Ho M, Griffith BP, Hardesty RL (1985) Morbidity of cytomegalovirus infection in recipients of heart or heart-lung transplants who received cyclosporine. J Infect Dis 152:1182–1191.PubMedGoogle Scholar
  27. 27.
    Dunnill MS (1984) Histopathology of rejection in renal transplantation. In: Dunnill MS (ed) Kidney transplantation. Gruen and Stratton, New York, p 355.Google Scholar
  28. 28.
    Dustin ML, Springer TA (1991) Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Ann Rev Immunol 9:27–66.Google Scholar
  29. 29.
    Fabricant CG, Fabricant J, Litrenta MM, Mimiek CR (1978) Virus-induced atherosclerosis. J Exp Med 148: 335–340.PubMedGoogle Scholar
  30. 30.
    Feehally J, Harris KP, Bennett SE, Walls J (1986) Is chronic renal transplant rejection a non-immunological phenomenom? Lancet ii: 486–488.Google Scholar
  31. 31.
    Fellstrom B, Klareskog L, Terracio L (1989) Platelet derived growth factor receptors in the kidney - importance of up-regulated expression in renal inflammation. Kidney Int 36: 1099–1102.PubMedGoogle Scholar
  32. 32.
    Fellstrom B, Larsson E (1993) Pathogenesis and treatment perspectives in chronic graft rejection. Immunol Rev 134: 83–98.PubMedGoogle Scholar
  33. 33.
    Fellstrom B, Dimeny E, Larsson E, Claesson K, Tufveson G (1990) Rapidly proliferative arteriopathy in cyclosporin-induced permanently surviving rat cardiac allografts simulating chronic vascular rejection. Clin Exp Immunol 80: 288–292.PubMedGoogle Scholar
  34. 34.
    Frostegard J, Nilsson J, Haegerstrand A, Hausten A, Wiazell H, Gidlund M (1990) Oxidised low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937. Proc Natl Acad Sci U S A 87: 904–908.PubMedGoogle Scholar
  35. 35.
    Frostegard J, Haegerstrand A, Gidlund M, Nilsson J (1991) Biologically modified low density lipoprotein increases the adhesive properties of vascular endothelial cells. Atherosclerosis 90:119–126.PubMedGoogle Scholar
  36. 36.
    Fujinami RS, Nelson JA, Walker L, Oldstone MB (1988) Sequence homology and immunologic cross reactivity of human cytomegalovirus with HLA-DR ß chain: a means for graft rejection and immunosuppression. J Virol 62:100–105.PubMedGoogle Scholar
  37. 37.
    Garovoy MR, Reddish MA, Busch GJ, Tilney NL (1982) Immunoglobulin secreting cells recovered from rejected human renal allografts. Transplantation 33:109–111.PubMedGoogle Scholar
  38. 38.
    Gasic AC, McGuire G, Krater S, Farhood Al, Goldstein MA, Smith CW, Entman ML, Taylor AA (1991) Hydrogen peroxide pretreatment of perfused canine vessels induces ICAM-1 and CD18-dependent neutrophil adherence. Circulation 84:2154–2166.PubMedGoogle Scholar
  39. 39.
    Goldberg LC, Cook T, Taube D (1994) Pretreatment of renal allografts with anti-CD45 antibodies: optimisation of perfusion technique. Transplant Immunol 2: 27–34.Google Scholar
  40. 40.
    Granger DN, Hollwarth ME, Parks DA (1986) Ischemia-reperfusion injury: role of oxygen derived free radicals. Acta Physiol Scand 548:47–63.Google Scholar
  41. 41.
    Grattan MT, Moreno-Cabral CE, Starnes VA, Oyer PE, Stinson EB, Shurnway NE (1989) Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis. JAMA 261: 3561–3566.PubMedGoogle Scholar
  42. 42.
    Green CJ, Healing G, Lunec J, Fuller BJ, Sirnkin S (1986) Evidence of free radical-induced damage in rabbit kidneys after single hypothermic preservation and autotransplantation. Transplantation 41:161–165.PubMedGoogle Scholar
  43. 43.
    Hajjar DP (1991) Viral pathogenesis of atherosclerosis: impact of molecular mimicry and viral genes. Am J Pathol 139:1195–1211.PubMedGoogle Scholar
  44. 44.
    Hayry P, Yilmaz S (1995) The role of growth factors in graft vessel disease. Transplant Proc 27:2066–2067.PubMedGoogle Scholar
  45. 45.
    Hayry P, Isoniemi H, Yilmaz S, Mennander A, Lemstrom K, RaisanenSokalowski A, Kosinen P, Ustinov J, Lautenschlager 1, Taskinen E, et al. (1993) Chronic allograft rejection. Immunol Rev 134: 33–81.PubMedGoogle Scholar
  46. 46.
    Hendrix MGR, Dormans PHJ, Kitslaar P, Bosman F, Bruggeman CA (1989) The presence of cytomegalovirus nucleic acids in arterial walls of atherosclerotic and non-atherosclerotic patients. Am J Pathol 134:1151–1157.PubMedGoogle Scholar
  47. 47.
    Hendrix MGR, Salimans MMM, van Boven CPA, Bruggeman CA (1990) High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis. Am J Pathol 136: 23–28.PubMedGoogle Scholar
  48. 48.
    Hill GS, Rosengard B, Benedict CI, Sachas DH (1990) Progressive glomerular hypertrophy and hyperfiltration glomerulosclerosis in chronic renal allograft rejection (abstract). J Am Soc Nephrol 1:749.Google Scholar
  49. 49.
    Hiki Y, Leong ASY, Mathew TH, Seymour AE, Pascoe V, Woodroffe AJ (1986) Typing of intraglomerular mononuclear cells are associated with transplant glomerular rejection. Clin Nephrol 26: 244–249.PubMedGoogle Scholar
  50. 50.
    Hoshino T, Maley WR, Bulkley GB, Williams GM (1988) Ablation of free radical-mediated reperfusion injury for the salvage of kidneys taken from non-heart beating donors. Transplantation 45:284–289.PubMedGoogle Scholar
  51. 51.
    Hruban RH, Wu T-C, Beschorner WE, Cameron DE, Ambinder RF, Baumgartner WA, Hutchins GM, Reitz BA (1990) Cytomegalovirus nucleic acids in allografted hearts. Hum Pathol 21: 981–983.PubMedGoogle Scholar
  52. 52.
    Hutchinson IV (1988) Specific immunosuppression. In: Morris PJ (ed) Kidney transplantation. Principles and practice. Saunders, Philadelphia, pp 389–416.Google Scholar
  53. 53.
    Hutchinson IV (1993) Effector mechanisms in transplant rejection — an overview. In: Rose ML, Yacoub MH (eds) Immunology of heart and lung transplantation. Edward Arnold, Boston, pp 3–21.Google Scholar
  54. 54.
    Ito Y, Iwaki Y, Terasaki PI (1986) Donor and recipient age effect. In: Terasaki PI (ed) Clinical transplants. UCLA Tissue Typing Laboratory, Los Angeles, p 189.Google Scholar
  55. 55.
    Iwamoto GK, Monick MM, Clark BD, Auron PE, Stinski MF, Hunninghake GW (1990) Modulation of interleukin IP gene expression by the immediate early genes of human cytomegalovirus. J Clin Invest 85:1853–1857.PubMedGoogle Scholar
  56. 56.
    Joseph JV, Guy SP, Brenchley PEC, Parrott NR, Short CD, Johnson RW, Hutchinson IV (1995) Th1 and Th2 cytokine gene expression in human renal allografts. Transplant Proc 27:915–916.PubMedGoogle Scholar
  57. 57.
    Kasiske BL, Kalil RSN, Lee HS, Raoke V (1991) Histopathological findings associated with a chronic progressive decline in renal allograft function. Kidney Int 40: 514–524.PubMedGoogle Scholar
  58. 58.
    Keane WF, Kasiske BL, O’Donnell MP (1988) Lipids and progressive glomerulosclerosis. Am J Nephrol 8: 261–271.PubMedGoogle Scholar
  59. 59.
    Keller RR, Peitchel JN, Goldman JN, Goldman M (1976) An IgG-Fc receptor induced in cytomegalovirus-infected human fibroblasts. J Immunol 116: 772–777.PubMedGoogle Scholar
  60. 60.
    Kemeny DM, Noble A, Holmes BJ, Diaz-Sanchez D (1994) Immune regulation: a new role for the CD8+ T cell. Immunol Today 15:107–110.PubMedGoogle Scholar
  61. 61.
    Keogh A, Kaan A, Doran T, Macdonald P, Bryant D, Spratt P (1995) HLA mismatching and outcome in heart, heart-lung and single lung transplantation. J Heart Lung Transplant 14: 444–451.PubMedGoogle Scholar
  62. 62.
    Kingma I, Chea R, Davidoff A, Grothman G, Benediktsson H, Paul LC (1990) Glomerular haemodynamics and focal glomerulosclerosis in chronic renal allograft rejection in the rat (abstract). J Am Soc Nephrol 1: 749.Google Scholar
  63. 63.
    Kirkman RL, Strom TB, Weir MR, Tilney NL (1982) Late mortality and morbidity in recipients of long-term renal allografts. Transplantation 34: 347–351.PubMedGoogle Scholar
  64. 64.
    Knight RJ, Kerman RH, Welsh M, Golden D, Schoenberg L, Van Buren CT, Lewis RM, Kahan BD (1991) Chronic rejection in primary renal allograft recipients under cyclo-sporine-prednisone immunosuppressive therapy. Transplantation 51: 355–359.PubMedGoogle Scholar
  65. 65.
    Deleted in production.Google Scholar
  66. 66.
    Land W, Schneeberger H, Schleibner S, Iiiner WD, Abendroth D, Rutili G, Arfors KE, Messmer K (1994b) Beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation 57:211–217.PubMedGoogle Scholar
  67. 67.
    Lau M, Terasaki PI, Park MS, Barbetti A (1991) International cell exchange. In: Terasaki PI (ed) Clinical transplants. UCLA Tissue Typing Laboratory, Los Angeles, pp 385–400.Google Scholar
  68. 68.
    Lechler RI, Batchelor JR (1982) Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 155: 31–41.PubMedGoogle Scholar
  69. 69.
    Legendre C, Droz D, Saltiel C (1990) Correlations between chronic rejection, pathologic lesions and HLA-class I and II compatibilities. In: Touraine JL, Traeger J, Betuel H (eds) Transplantation and clinical immunology XXI. Elsevier, New York, pp 157–165.Google Scholar
  70. 70.
    Lemstrom KB, Brüning JH, Bruggeman CA, Lautenshlager IT, Hayry PJ (1993) Cytomegalovirus infection enhances smooth muscle cell proliferation and intimai thickening of rat aortic allografts. J Clin Invest 92: 549–558.PubMedGoogle Scholar
  71. 71.
    Loebe M, Schuier S, Ortwin Z, Warnecke E, Fleck E, Hetzer R (1990) Role of cytomegalovirus infection in the development of coronary artery disease in the transplanted heart. J Heart Transplant 9: 707–711.PubMedGoogle Scholar
  72. 72.
    Lowry RP (1993) The relationship of IL-4, IL-10 and other cytokines to transplant tolerance. Transplant Sci 3:104–112.Google Scholar
  73. 73.
    Luscher TF (1990) The endothelium. Target and promoter of hypertension? Hypertension 15:482–485.PubMedGoogle Scholar
  74. 74.
    McDonald K, Rector CS, Braunlin EA, Kubo SH, Olivari MT (1989) Association of coronary artery disease in cardiac transplant recipients with cytomegalovirus infection. Am J Cardiol 64: 359–362.PubMedGoogle Scholar
  75. 75.
    McCord JM (1985) Oxygen-derived free radicals in post ischemic tissue injury. N Engl J Med 312:159–163.PubMedGoogle Scholar
  76. 76.
    MacGregor RR, Friedman HM, Macarak EJ, Kefalides NA (1980) Virus infection of endothelial cells increases granulocyte adherence. J Clin Invest 65:1469–1477.PubMedGoogle Scholar
  77. 77.
    Mason DW, Morris PJ (1986) Effector mechanisms in allograft rejection. Annu Rev Immunol 4:119–145.PubMedGoogle Scholar
  78. 78.
    Matas AJ, Sibley R, Mauer SM, Kim Y, Sutherland DER, Simmons RL, Najarian JS (1982) Pre-discharge, post-transplant kidney biopsy does not predict rejection. J Surg Res 32: 269–274.PubMedGoogle Scholar
  79. 79.
    Maruya E, Takemoto S, Terasaki PI (1994) HLA matching: identification of permissible HLA mismatches. In: Terasaki PI, Cecka JM (eds) Clinical transplants. UCLA Tissue Typing Laboratory, Los Angeles, pp 285–292.Google Scholar
  80. Melnick JL, Dreesman GR, McCollum CH, Petrie BL, Burek J, DeBakey ME (1983) Cytomegalovirus antigen within human arterial smooth muscle cells. Lancet ii: 644–647.Google Scholar
  81. 81.
    Melnick JL, Adam E, DeBakey ME (1990) Possible role of cytomegalovirus in athero-genesis. JAMA 262: 2204–2207.Google Scholar
  82. 82.
    Menger MD, Lehr HA, Messmer K (1991) Role of oxygen radicals in the microcirculatory manifestations of postischemic injury. Klin Wochenschr 69:1050–1055.PubMedGoogle Scholar
  83. 83.
    Modena FM, Hostetter TH, Salahudeen AK, Najarian JS, Matas AJ, Rosenberg ME (1991) Progression of kidney disease in chronic renal transplant rejection. Transplantation 52: 239–244.PubMedGoogle Scholar
  84. 84.
    Moretta L, Ciccone E, Moretta A, Hoglund P, Oulen C, Karre K (1992) Allorecognition by NK cells: nonself or no self? Immunol Today 13: 300–306.PubMedGoogle Scholar
  85. 85.
    Munger KA, Coffman TM, Griffiths RC, Fogo A, Badr KF (1983) Determinants of long-term renal allograft survival. Transplantation 55:1219–1224.Google Scholar
  86. 86.
    Naimark DMJ, Cole E (1994) Determinants of long-term renal allograft survival. Transplant Rev 8: 93–113.Google Scholar
  87. 87.
    Najarian JS, Fryd DS, Strand M, Canafax DM, Ascher NL, Payne WD, Simmons RL, Sutherland DE (1985) A single institution, randomized, prospective trial of cyclosporine versus azathioprine-antilymphocyte globulin for immunosuppression in renal allograft recipients. Ann Surg 201:142–157.PubMedGoogle Scholar
  88. 88.
    Nasasdy T, Ormos J, Stiller D, Csajbak E, Szenohradsky P (1988) Tubular ultrastructure in rejected human renal allografts. Ultrastruct Pathol 12:195–207.Google Scholar
  89. 89.
    Nath KA (1993) The role of tubulo-interstitial processes in progressive renal disease. In: El Naha AM, Mallick NO, Anderson S (eds) Prevention of progressive renal failure. Oxford University Press, Oxford, pp 62–97.Google Scholar
  90. 90.
    Nath KA, Hostetter MK, Hostetter TH (1985) Pathophysiology of chronic tubulo-interstitial disease in rats: interactions of dietary acid load, ammonia and complement component C3. J Clin Invest 76:667–675.PubMedGoogle Scholar
  91. 91.
    Nathan CF, Murray HW, Cohn ZA (1980) The macrophage as an effector cell. N Engl J Med 303: 622–626.PubMedGoogle Scholar
  92. 92.
    Nëild GH, Taube DH, Hartley RB, Bignardi L, Cameron JS, Williams DG, Ogg CS, Rudge CJ (1986) Morphological differentiation between rejection and cyclosporine nephrotoxicity in renal allografts. J Clin Pathol 39:152–159.PubMedGoogle Scholar
  93. 93.
    Novick AC, Gephardt G, Guz B, Steinmuller D, Tabbs RR (1991) Longterm follow-up after partial removal of a solitary kidney. N Engl J Med 325:1058–1062.PubMedGoogle Scholar
  94. 94.
    Nyengaard JR, Bendtsen TF (1992) Glomerular number and size in relation to age, kidney weight and body surface in normal man. Anat Ree 232:194–201.Google Scholar
  95. 95.
    Oguma S, Belle S, Starzl TE, Demetris AJ (1989) A histometric analysis of chronically rejected human liver allografts: insights into the mechanisms of bile duct loss: direct immunologic and ischemic factors. Hepatology 9: 204–209.PubMedGoogle Scholar
  96. 96.
    Opelz G (1984) Blood transfusions and renal transplantation. In: Morris PJ (ed) Kidney transplantation. Principles and practice. Grune and Stratton, Orlando, Florida, pp 323–324.Google Scholar
  97. 97.
    Opelz G (1988) Influence of recipient and donor age on pediatric renal transplantation. Transplant Int 1:95–98.Google Scholar
  98. 98.
    Opelz G, for the Collaborative Transplant Study (1991) Strength of HLAA, HLA-B and HLA-DR mismatches in relation to short-and long-term kidney graft survival. Transplant Int 5[Suppl]:621.Google Scholar
  99. 99.
    Orosz CG (1994) Endothelial activation and chronic allograft rejection. Clin Transplant 8: 299–303.PubMedGoogle Scholar
  100. 100.
    Parks DA, Granger DN (1988) Ischemia-reperfusion injury: a radical view. Hepatology 8:680–682.PubMedGoogle Scholar
  101. 101.
    Patarroyo MP, Prieto J, Rincón J, Timonen T, Lundberg C, Lindborn L, Asjo B, Gahmberg CG (1990) Leukocyte-cell adhesion: a molecular process fundamental in leukocyte physiology. Immunol Rev 114:67–108.PubMedGoogle Scholar
  102. 102.
    Paul LC, Benediktsson H (1995) Post-transplant hypertension and chronic renal allograft failure. Kidney Int 52[Suppl]: 34–37.Google Scholar
  103. 103.
    Paul LC, Fellstrom B (1992) Chronic vascular *rejection of the heart and kidney. Have rational treatment options emerged? Transplantation 53:1169–1179.PubMedGoogle Scholar
  104. 104.
    Paul LC, Hayry P, Foegh M, Dennis MJ, Mihatsch MJ, Larsson E, Fellstrom B (1993) Diagnostic criteria for chronic rejection/accelerated graft atherosclerosis in heart and kidney transplants: joint proceedings from the Fourth Alexis Carrel Conference on Chronic Rejection and Accelerated Arteriosclerosis in Transplanted Organs. Transplant Proc 25: 2022–2023.PubMedGoogle Scholar
  105. 105.
    Pinsky DJ, Oz MC, Koga S, Taha Z, Broekman MJ, Marcus AJ, Liao H, Naka Y, Brett J, Cannon PJ, et al. (1994) Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway. J Clin Invest 93:2291–2297.PubMedGoogle Scholar
  106. 106.
    Pirsch JD, Sollinger HW, Kalayoglu M, Stratta RJ, D’Alessandro AM, Armbrush MJ, Beizer FO (1988) Living unrelated renal transplantation: results in 40 patients. Am J Kidney Dis 12:499–503.PubMedGoogle Scholar
  107. 107.
    Rao KV, Kasiske BL, Odlund MD, Ney AL, Anderson RC (1990) Influence of cadaver donor age on posttransplant renal function and graft outcome. Transplantation 49: 91–95.PubMedGoogle Scholar
  108. 108.
    Reddehase MJ, Keil GM, Koszinowski UH (1984a) The cytolytic T lymphocyte response to the murine cytomegalovirus. 1. Distinct maturation stages of cytolytic T lymphocytes constitute the cellular immune response during acute infection of mice with the murine cytomegalovirus. J Immunol 132:482–489.PubMedGoogle Scholar
  109. 109.
    Reddehase MJ, Keil GM, Koszinowski UH (1984b) The cytolytic T lymphocyte response to the murine cytomegalovirus. 11. Detection of virus replication stage-specific antigen by separate populations of in vivo active cytolytic T lymphocyte precursors. Eur J Immunol 14: 56–61.PubMedGoogle Scholar
  110. 110.
    Regnstrom J, Nilsson J, Tornvall P, Landou C, Hamsten A (1992) Susceptibility of low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 339: 1183–1186.PubMedGoogle Scholar
  111. 111.
    Reinke P, Fietze E, Ode-Hakim S, Prosch S, Lippert J, Ewert R, Volk HD (1994) Late acute renal allograft rejection and symptomless cytomegalovirus infection. Lancet 344: 1737–1738.PubMedGoogle Scholar
  112. 112.
    Remuzzi G, Bertani T (1990) Is glomerulosclerosis a consequence of altered glomerular permeability to macromolecules? Kidney Int 38: 384–394.PubMedGoogle Scholar
  113. 113.
    Rennke HG (1986) Pathology of glomerular hyperfiltration. In: Mitch WE, Brenner BM, Stein JH (eds) The progressive nature of renal disease. Churchill-Livingstone, New York, p 111 (Contemporary Issues in Nephrology, vol 14).Google Scholar
  114. 114.
    Roberts AB, Sporn MB (1993) Physiological actions and clinical applications of transforming growth factor-β (TGF- β). Growth Factors 8:1–9.PubMedGoogle Scholar
  115. 115.
    Rose A, Uys CJ (1990) Pathology of graft atherosclerosis (chronic rejection). In: Cooper DKC, Novitsky D (eds) Transplantation and replacement of thoracic organs. Kluwer, Boston.Google Scholar
  116. 116.
    Ross R (1986) The pathogenesis of atherosclerosis — an update. N Engl J Med 314:488–500.PubMedGoogle Scholar
  117. 117.
    Ross R, Glomset JA (1976) The pathogenesis of atherosclerosis. N Engl J Med 295:369–377.PubMedGoogle Scholar
  118. 118.
    Sharma VK, Bologa RM, Xu GP, Li B, Mouradian J, Wang J, Serur D, Rao V, Suthanthiran (1996) Intragraft TGF-betal mRNA: a correlate of interstitial fibrosis and chronic allograft nephropathy. Kidney Int 49:1297–1303.PubMedGoogle Scholar
  119. 119.
    Shellarn GR, Allen JE, Papadimitriou JM, Bancroft GJ (1981) Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proc Natl Acad Sci USA 78: 5104–5108.Google Scholar
  120. 120.
    Shimokado K, Raines EW, Madtes DK, Barrett TB, Benditi EP, Ross R (1985) A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 43: 277–286.PubMedGoogle Scholar
  121. 121.
    Sibley RK (1994) Morphological feature of chronic rejection in kidney and less commonly transplanted organs. Clin Transplant 8:293–298.PubMedGoogle Scholar
  122. 122.
    Sibley RK, Rynasiewicz J, Ferguson RM, Fryd D, Sutherland DER, Simmons RL, Najarian JS (1983) Morphology of cyclosporine nephrotoxicity and acute rejection in patients immunosuppressed with cyclosporine and prednisolone. Surgery 94:225–234.PubMedGoogle Scholar
  123. 123.
    Sigal NH, Dumont FJ (1992) Cyclosporin A, FK506 and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu Rev Immunol 10:519–560.PubMedGoogle Scholar
  124. 124.
    Silver BJ, Jaffer FE, Abboud HE (1989) Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens. Proc Natl Acad Sci U S A 86: 1056–1060.PubMedGoogle Scholar
  125. 125.
    Solez K, Axelsen RA, Benediktsson H, Burdick JF, Cohen AH, Colvin RB, Croker BP, Droz D, Dunnill MS, Halloran PF, et al. (1993 a) International standardisation of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int 44:411–422.PubMedGoogle Scholar
  126. 126.
    Solez K, Racusen LC, Marcussen N, Slatnik 1, Keown P, Burdick JF, Olsen S (1993 b) Morphology of ischemic acute renal failure, function, and cycosporine toxicity in cyclo-sporine-treated renal allogaft recipients. Kidney Int 43:1058–1067.PubMedGoogle Scholar
  127. 127.
    Span AHM, Grauls G, Bosman F, van Boven CPA, Bruggeman CA (1992) Cytomegalovirus infection induces vascular injury in the rat. Atherosclerosis 93:41–52.PubMedGoogle Scholar
  128. 128.
    Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425–434.PubMedGoogle Scholar
  129. 129.
    Squifflet JP, Pirson Y, Poncelet A, Gianello P, Alexandre GP (1990) Unrelated living donor kidney transplantation. Transplant Int 3:32–35.Google Scholar
  130. 130.
    Starzi TE, Demetris AJ, Murase N, Ildstad S, Ricordi C, Trucco M (1992) Cell migration, chimerism, and graft acceptance. Lancet 339:1579.Google Scholar
  131. 131.
    Starzi TE, Demetris AJ, Trucco M, Zeevi A, Ramos H, Terasaki P, Rudert WA, Kocova M, Ricordi C, Ildstad S, Murase N (1993) Chimerism and donor-specific non-reactivity 27 to 29 years after kidney allotransplantation. Transplantation 55:1272–1277.Google Scholar
  132. 132.
    Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witzturn JL (1989) Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320:915–924.Google Scholar
  133. 133.
    Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9: 271–296.PubMedGoogle Scholar
  134. 134.
    Steinman RM, Cohn ZA (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. 1. Morphology, quantitation, tissue distribution. J Exp Med 137: 1142–1162.PubMedGoogle Scholar
  135. 135.
    Stewart JR, Frist WH, Merrill WH (1990) Oxygen scavengers in myocardial preservation during transplantation. Methods Enzymol 186: 742–748.PubMedGoogle Scholar
  136. 136.
    Stiko-Rahm A, Hultgardh-Nilsson A, Regnstrom J, Hamsten A, Nilsson J (1992) Native and ’ oxidised LDL enhances production of PDGF-AA and the surface expression of PDGF receptors in cultured human arterial smooth muscle cells. Arterioscler Thromb 12: 1099–1109.PubMedGoogle Scholar
  137. 137.
    Strom TB, Tilney NL, Carpenter CB, Busch GJ (1975) Identity and cytotoxic capacity of cells infiltrating renal allografts. N Engl J Med 292:1257–1263.PubMedGoogle Scholar
  138. 138.
    Takemoto S, Terazaki PI, Cecka JM, Cho YW, Gjertson DW (1992) Survival of nationally shared, HLA-matched kidney transplants from cadaveric donors. N Engl J Med 327: 834–839.PubMedGoogle Scholar
  139. 139.
    Terasaki PI, Cecka JM, Cho Y (1990) Overview. In: Terasaki PI (ed) Clinical transplants. UCLA Tissue Typing Laboratory, Los Angeles, pp 585–601.Google Scholar
  140. 140.
    Terasaki PI, Cecka M, Gjertson DW, Takernoto S (1995) High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 333: 333–336.PubMedGoogle Scholar
  141. 141.
    Terasaki PI, Koyama H, Cecka JM, Gjertson DW (1994) The hyperfiltration hypothesis in renal transplantation. Transplantation 57(10): 1450–1454.PubMedGoogle Scholar
  142. 142.
    Thorogood J, Van Houwelingen HQ, Van Rood JJ, Zantroort FA, Schrender GM, Persijn GG (1992) Factors contributing to long term kidney graft survival in Eurotransplant. Transplantation 54: 152–158.PubMedGoogle Scholar
  143. 143.
    Tullius SG, Tilney NL (1995) Both alio antigen-dependent and independent factors influence chronic allograft rejection. Transplantation 59: 313–318.PubMedGoogle Scholar
  144. 144.
    Van Es A, Hermans J, Van Bockel JH, Persijn GG, van Hooff JP de Graeff J (1983) Effect of warm ischaemia time and HLA (Aand B) matching on renal cadaveric graft survival and rejection episodes. Transplantation 36:255–258.PubMedGoogle Scholar
  145. 145.
    van Rood JJ (1967) A proposal for international cooperation in Organtransplantation. In: Curtoni ES, Mattiuz PL, Tosi RM (eds) Histocompatibility testing. Munksgaard, Copenhagen, pp 451–452.Google Scholar
  146. 146.
    Wanders A, Akyurek NIL, Waltenberger J, Stafberg C, Larsson E, Zhiping R, Funa K, Fellstrom B (1993) The impact of ischemia time on chronic vascular rejection in the rat -effects of angiopeptin. Transplant Proc 25: 2098–2099.PubMedGoogle Scholar
  147. 147.
    Wanders A, Akyurek ML, Waltenberger J, Ren ZP, Stafberg C, Funa K, Larsson E, Fellstrom B (1995) Ischemia induced transplant arteriosclerosis in the rat. Arterioscler Thromb 15: 145–155.Google Scholar
  148. 148.
    Yoshida Y, Fogo A, Ichikawa I (1989) Glomerular haemodynamic changes vs hypertrophy in experimental glomerular sclerosis. Kidney Int 35: 654–660.PubMedGoogle Scholar
  149. 149.
    Yuge J, Cecka JM (1992) Sex and age effects in renal transplantation. In: Terasaki PI (ed) Clinical transplants. UCLA Tissue Typing Laboratory, Los Angeles, pp 269.Google Scholar

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© Springer-Verlag Berlin Heidelberg 1999

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  • S. M. Dodd

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