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Transplantation Immunology — The Role of Human Leucocyte Antigen in Allorecognition

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Transplantation Pathology

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 92))

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Abstract

Transplantation of organs and bone marrow is the therapy of choice for an increasing number of patients. The greatest problem encountered after transplantation of cells and tissue from a genetically different donor is that the immune system of the recipient recognizes the transplant as foreign and will try get rid of it in essentially the same way as the immune system deals with invading organisms. The result is a host-versus-graft (HVG) response, which may lead to rejection of the transplant. Similarly, T lymphocytes (T cells for short) transferred along with the stem cells in a donor bone marrow graft can recognize host cells as foreign and will initiate a graft-versus-host (GVH) response, which may cause serious and often fatal GVH disease.

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  1. F. Vartdal
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  2. E. Thorsby
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C. L. Berry

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© 1999 Springer-Verlag Berlin Heidelberg

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Vartdal, F., Thorsby, E. (1999). Transplantation Immunology — The Role of Human Leucocyte Antigen in Allorecognition. In: Berry, C.L. (eds) Transplantation Pathology. Current Topics in Pathology, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59877-7_1

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  • DOI: https://doi.org/10.1007/978-3-642-59877-7_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64162-6

  • Online ISBN: 978-3-642-59877-7

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