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Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies pp 319–325Cite as

Fertility Following Treatment of Testicular Carcinoma

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Testicular cancer usually occurs in young men, many of whom have not yet established a family at the time at which the diagnosis of cancer is made. Most of the tumors are germ cell tumors, which are highly curable with surgery, radiotherapy, chemotherapy, or multimodality treatment. The primary goal for urologists, radiotherapists, and medical oncologists is, of course, to cure the patient. Despite the obvious stress to the patient caused by the news of a diagnosis of testicular cancer, one must take time to discuss the fertility issues with the patient. Unlike Hodgkin’s disease, which also affects young men of reproductive age and is highly curable, testicular cancer involves an organ intrinsically linked with fertility, sexuality, and self-image (see Chap. 36). Rieker et al. (1990) showed that there were different fertility-related behaviors in these patients. Young childless patients without a stable relationship were more interested in sperm banking, while men who also lost their ejaculatory function after treatment had the greatest risk of continued distress regarding infertility. Rieker et al. showed that adjustment to infertility is a complex process that begins at diagnosis and extends long after treatment has been completed.

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References

  • Aass N, Fossa SD, Theodorsen L, Norman N (1991) Prediction of long term gonadal toxicity after standard treatment for testicular cancer. Eur J Cancer 27: 1087–1091

    Article  PubMed  CAS  Google Scholar 

  • Baniel J, Roth BJ, Foster RS, Donohue JP (1995) Cost and risk benefit in the management of clinical stage II non- seminomatous testicular tumors. Cancer 75: 2897–2903

    Article  PubMed  CAS  Google Scholar 

  • Bar-Chama N, Herr HW, Sogani PC, et al. (1992) The fertility of males with stage I NSGCT managed on surveillance alone. J Urol 147: 337A

    Google Scholar 

  • Bell IS, Alder EA (1994) Psychology of infertility and management. In: Hargreave TB (ed) Male infertility. Springer, London Berlin Heidelberg New York, pp 177–185

    Chapter  Google Scholar 

  • Berthelsen IG, Skakkebaek NE (1983) Gonadal function in men with testis cancer. Fértil Steril 39: 68–71

    PubMed  CAS  Google Scholar 

  • Brennemann W, Stoffel-Wagner B, Helmers A, Mezger I, läger N, Klingmüller D (1997) Gonadal function of patients treated with cisplatin based chemotherapy for germ cell cancer. J Urol 158: 844–850

    Article  PubMed  CAS  Google Scholar 

  • Carroll PR, Morse MI, Whitmore WF Ir, et al. (1987) Fertility status of patients with clinical stage I testis tumors on a surveillance protocol. J Urol 138: 70–72

    PubMed  CAS  Google Scholar 

  • Coogan CL, Hejase MI, Wahle GR, Foster RS, Rowland RG, Bihrle R, Donohue IP (1996) Nerve sparing post-chemotherapy retroperitoneal lymphnode dissection for advanced testicular cancer. I Urol 156: 1656–1658

    CAS  Google Scholar 

  • Donohue IP, Foster RS, Rowland RG, Bihrle R, Iones I, Geier G (1990) Nerve–sparing retroperitoneal lymphadenectomy with preservation of ejaculation. J Urol 144: 287–290

    PubMed  CAS  Google Scholar 

  • Drasga RE, Einhorn LH, Williams SD, et al. (1983) Fertility after chemotherapy for testicular cancer. J Clin Oncol 1: 179–183

    PubMed  CAS  Google Scholar 

  • Ferreira U, Netto NR Ir, Esteves SC, Rivero MA, Schirren C (1991) Comparative study of the fertility potential of men with only one testicle. Scan I Urol Nephrol 25: 255–259

    Article  CAS  Google Scholar 

  • Fossa SD, Ous S, Abyholm T, et al. (1985) Post treatment fertility in patients with testicular cancer: influence of ret-roperitoneal lymph node dissection on ejaculatory potency. Br I Urol 57: 204–209

    Article  CAS  Google Scholar 

  • Fossa SD, Aass N, Molne K (1989a) Is routine pretreatment cryopreservation of semen worthwhile in the management of patients with testicular cancer? Br J Urol 64: 524–529

    Article  PubMed  CAS  Google Scholar 

  • Fossa SD, Aass N, Kaalhus O (1989b) Long-term morbidity after infradiaphragmatic radiotherapy in young men with testicular cancer. Cancer 64: 404

    Article  PubMed  CAS  Google Scholar 

  • Fossa SD, Theodorsen L, Norman N, Aabyholm T (1990) Recovery of impaired pretreatment spermatogenesis in testicular cancer. Fértil Steril 54: 493–496

    PubMed  CAS  Google Scholar 

  • Foster RS, Rubin LR, McNulty A, et al. (1991) Detection of antisperm antibodies in patients with primary testicular cancer. Int] Androl 14: 179–182

    Article  CAS  Google Scholar 

  • Foster RS, McNulty A, Rubin LR, et al. (1994) The fertility of patients with clinical stage I testis cancer managed by nerve sparing retroperitoneal lymph node dissection. I Urol 152: 1139–1143

    CAS  Google Scholar 

  • Fritz K, Weissbach L (1985) Sperm parameters and ejaculation before and after operative treatment of patients with germ-cell testicular cancer. Fértil Steril 43: 451–454

    PubMed  CAS  Google Scholar 

  • Garnick MB, Richie IP (1986) Toward more rational management for stage I testicular cancer. J Clin Oncol 4: 1021–1023

    PubMed  CAS  Google Scholar 

  • Giwercman A, von der Maase H, Berthelsen IG, Rorth M, Bertelsen A, Skakkebaek NE (1991) Localized irradiation of testes with carcinoma in situ: effects on Leydig cell function and eradication of malignant germ cells in 20 patients. I Clin Endocrinol Metab 73: 596–603

    Article  CAS  Google Scholar 

  • Hansen PV, Trykker H, Andersen I, Helkjaer PE (1989) Germ cell function and hormonal status in patients with testicu¬lar cancer. Cancer 64: 956–961

    Article  PubMed  CAS  Google Scholar 

  • Hansen PV, Trykker H, Svennekjaer IL, Hvolby I (1990) Long-term recovery of spermatogenesis after radiotherapy in patients with testicular cancer. Radiat Oncol 18: 117–125

    Article  CAS  Google Scholar 

  • Hansen PV, Glavind K, Panduro J, Pedersen M (1991) Paternity in patients with testicular germ cell cancer: pretreatment and post-treatment findings. Eur J Cancer 27: 1385–1389

    Article  PubMed  CAS  Google Scholar 

  • Hansen SW, Berthelsen JG, von der Maase H (1990) Long-term fertility and Leydig cell function in patients treated for germ cell cancer with cisplatin, vinblastine and bleomycin versus surveillance. J Clin Oncol 8: 1695–1698

    PubMed  CAS  Google Scholar 

  • Höbarth K, Klingler HC, Maier U, Kollaritsch H (1994) Incidence of antisperm antibodies in patients with carcinoma of the testis and in subfertile men with normo-gonadotropic oligoasthenoteratozoospermia. Urol Int 52: 162–165

    Article  PubMed  Google Scholar 

  • Horwich A, Nicholls EJ, Hendry WF (1988) Seminal analysis after orchiectomy in stage I teratoma. Br J Urol 62: 79

    Article  PubMed  CAS  Google Scholar 

  • Jarow JP (1994) Life-threatening consitions associated with male infertility. Urol Clin North Am 21: 409–415

    PubMed  CAS  Google Scholar 

  • Jewett MAS, Thachill JV, Harris JF (1983) Exocrine function of testis with germinal testicular tumour. Br Med J 286:1849– 1851

    Google Scholar 

  • Joos H, Chandra I, Frick J (1993) Endokrinologie und Fertilität beim Hodentumor im Stadium I. Helv Chir Acta 60:367– 370

    Google Scholar 

  • Jorgensen N, Müller J, Giwercman A, Skakkebaek NE (1990) Clinical and biological significance of carcinoma in situ of the testis. Cancer Surv 9: 287–302

    PubMed  CAS  Google Scholar 

  • Kliesch S, Behre HM, Jürgens H, Nieschlag E (1996) Cryopreservation of semen from adolescent patients with malignancies. Med Pediatr Oncol 26: 20–27

    Article  PubMed  CAS  Google Scholar 

  • Kreuser ED, Klingmüller D, Thiel E (1993) The role of LHRH analogues in protecting gonadal functions during chemotherapy and irradiation. Eur Urol 23: 157–164

    PubMed  CAS  Google Scholar 

  • Lange PH, Chang WY, Fraley EE (1987) Fertility issues in the therapy in nonseminomatous testicular tumors. Urol Clin North Am 14: 731–747

    PubMed  CAS  Google Scholar 

  • Morrish DW, Venner PM, Siy O, Barrron G, Bhardway D, Outhet D (1990) Mechanisms of endocrine dysfunction in patients with testicular cancer. J Natl Cancer Inst 82:412– 418

    Google Scholar 

  • Mortimer D (1994) Semen analysis and other standard laboratory tests. In: Hargreave TB (ed) Male infertility. Springer, London Berlin Heidelberg New York, pp 37–42

    Chapter  Google Scholar 

  • Mulvihill JJ, Meyers MH, Connelly R, et al. (1987) Cancer in offspring of long term survivors of childhood and adolescence cancer. Lancet 11: 813

    Article  Google Scholar 

  • Nijman JM, Schraffordt Koops H, Kremer J, et al. (1987) Gonadal function after surgery and chemotherapy in men with stage II and III nonseminomatous testicular tumors. J Clin Oncol 5: 651

    PubMed  CAS  Google Scholar 

  • Ohl DA, Denil J, Bennet CJ, Randolph JF, Menge AC, McCabe M (1991) Electroejaculation following retroperitoneal lymphadenectomy. J Urol 145: 980–983

    PubMed  CAS  Google Scholar 

  • Oliver RTD, Oliver JC (1996) Endocrine hypothesis for declining sperm count and incidence of cancer. Lancet 347:339– 340

    Google Scholar 

  • Palmieri G, Lotrecchiano G, Ricci G, Lombardi G, Bianco AR, Torino G (1996) Gonadal function after multimodality treatment in men with testicular germ cell cancer. Eur J Endocrinol 134: 431–436

    Article  PubMed  CAS  Google Scholar 

  • Pont J, Albrecht W (1997) Fertility after chemotherapy for testicular germ cell cancer. Fertil Steril 68: 1–5

    Article  PubMed  CAS  Google Scholar 

  • Presti JC, Herr HW, Carroll PR (1993) Fertility and testis cancer. Urol Clin North Am 20: 173–179

    PubMed  CAS  Google Scholar 

  • Rieker PP, Fitzgerald EM, Kalish LA (1990) Adaptive behavioral responses to potential infertility among survivors of testis cancer. J Clin Oncol 8: 347–355

    PubMed  CAS  Google Scholar 

  • Rüssel LD, Rüssel JA (1991) Short–term morphological response of the rat testis to administration of five chemo– therapeutic agents. Am J Anat 192: 142–168

    Article  Google Scholar 

  • Sanger WG, Olson JH, Sherman JK (1992) Semen cryobanking for men with cancer-criteria change. Fertil Steril 58: 1024–1027

    PubMed  CAS  Google Scholar 

  • Senturia YD, Peckham CS (1990) Children fathered by men treated with chemotherapy for testicular cancer. Eur J Cancer 26: 429–432

    Article  PubMed  CAS  Google Scholar 

  • Thachil JW, Jewett MAS, Rider WD (1981) The effects of cancer and cancer therapy on male fertility. J Urol 126:141– 145

    Google Scholar 

  • Tournaye H, Camus M, Bollen N, Wisanto A, Van Steirteghem AC, Devroey P (1991) In vitro fertilization techniques with frozen-thawed sperm: a method for preserving the progenitive potential of Hodgkin patients. Fertil Steril 55: 443–445

    PubMed  CAS  Google Scholar 

  • Von der Maase H, Rorth M, Walbom-Jorgensen S, et al. (1986) Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: study of 27 cases in 500 patients. BMJ 293: 1398–1401

    Article  PubMed  Google Scholar 

  • Wanderas EM, Fossa SD, Meilo A, et al. (1990) Serum follicle stimulating hormone: predictive of cancer in the remaining testes in patients with unilateral testicular cancer. Br J Urol 66: 315

    Article  PubMed  CAS  Google Scholar 

  • Weissbach L, Boedefield EA, Oberdorster W (1985) Modified RLND as a means to preserve ejaculation. In: Khoury S, Kuss R, Murphy GP, et al. (eds) Testicular cancer. Liss, New York

    Google Scholar 

  • Willemse PHB, Sleijfer D, Sluiter WI, et al. (1983) Altered Leydig cell function in patients with testicular cancer: evidence for bilateral testicular defect. Acta Endocrinol 102: 616–619

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Urology and Fertility Center Leuven, University Hospitals Gasthuisberg, Catholic University of Leuven, Herestraat 49, B-3000, Leuven, Belgium

    D. J. M. K. De Ridder MD (Consultant Urologist)

  2. Department of Urology, University Hospitals Gasthuisberg, Catholic University of Leuven, Herestraat 49, B-3000, Leuven, Belgium

    L. Baert MD, PhD (Chairman)

Authors
  1. D. J. M. K. De Ridder MD
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  2. L. Baert MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology Kenneth Norris Jr. Cancer Hospital and Research Institute, University of Southern California School of Medicine, 1441 Eastlake Avenue, 90033-004, Los Angeles, CA, USA

    Zbigniew Petrovich MD, FACR (Professor of Radiation Oncology and Urology Chairman) (Professor of Radiation Oncology and Urology Chairman)

  2. Department of Urology, Catholic University of Leuven, University Hospitals Gasthuisberg, 49, Herestraat, B-3000, Leuven, Belgium

    Luc Baert MD, PhD (Professor and Chairman) (Professor and Chairman)

  3. Hylda Cohn/American Cancer Society, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor) (Professor of Clinical Oncology, and Professor)

  4. Department of Radiation Oncology, Allegheny University of the Health Sciences Allegheny University Hospitals, Hahnemann Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor) (Professor of Clinical Oncology, and Professor)

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© 1999 Springer-Verlag Berlin Heidelberg

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De Ridder, D.J.M.K., Baert, L. (1999). Fertility Following Treatment of Testicular Carcinoma. In: Petrovich, Z., Baert, L., Brady, L.W. (eds) Carcinoma of the Kidney and Testis, and Rare Urologic Malignancies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59839-5_26

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  • DOI: https://doi.org/10.1007/978-3-642-59839-5_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64144-2

  • Online ISBN: 978-3-642-59839-5

  • eBook Packages: Springer Book Archive

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