Abstract
IOERT is an attractive radiotherapy technique able to deliver a high-quality electron radiation boost to most regions of the human anatomy (Fig. 15.1). Its feasibility is well proven during cancer surgery (CALVO et al. 1992b). Local tumor control rates in radical treatment programs combining a single-dose IOERT boost (10–20Gy), external beam fractionated irradiation (45–50Gy), minimal postsurgical cancer residue and chemotherapy (when indicated) have been consistently reported in the range of 85%–100%. Results in association with palliative surgery (no resection or atypical resections with macroscopic tumor residue) are modest in terms of long-term survival, but local control rates are described in the range of 40%–60% (CALVO et al. 1993). Tolerance of normal tissues to the combination of IOERT boost single high-dose (10–20Gy) and fractionated radiotherapy (45–50Gy) are better understood in the 1990s and with the appropriate dose prescription restrictions there is no compromise of the therapeutic index, in terms of excessive severe toxicity of clinical relevance (SHAW et al. 1990).
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Calvo, F.A., Aristu, J.J., Moreno, M., Santos, M., Fisher, S.A. (1999). Intraoperative Radiotherapy for Lung Cancer. In: Van Houtte, P., Klastersky, J., Rocmans, P. (eds) Progress and Perspective in the Treatment of Lung Cancer. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59824-1_15
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