Skip to main content
SpringerLink
Log in
Book cover

Trends in Contrast Media pp 95–102Cite as

Neurotoxicity

  • Chapter

  • 187 Accesses

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Neurotoxicity is the degree of toxicity produced by molecules of contrast media in contact with the central nervous system following intracisternal or intrathecal injection. Like systemic toxicity, neurotoxicity is expressed as LD50 (in g I/kg or in mmol/kg) and corresponds to the intrathecal dose inducing death in 50% of experimental animals after injection. The neurotoxicity index is defined as the ratio between intravenous LD50 and intrathecal LD50.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams MD, Hopkins RM,Ferrendelli JA (1988) A rat EEG model for evaluating contrast media neurotoxicity. Invest Radiol (Suppl 1) 23:S217–S219.

    CAS  Google Scholar 

  • Adams MD, Ralston WH, Ferrendelli JA (1990) Electroencephalographic effects of intracisternally injected nonionic X-ray contrast media in rats. Invest Radiol 25:S86–S87.

    Article  PubMed  CAS  Google Scholar 

  • Almén T (1989) Relations between chemical structure, animal toxicity and clinical adverse effects of contrast media. In: Enge I, Edgren J (eds) Patient safety and adverse events in contrast medium examinations. Elsevier Science, Amsterdam, p 25.

    Google Scholar 

  • Aulie A (1980) Effect of iohexol, metrizamide and ioxaglate on the blood-brain barrier. Acta Radiol (Suppl) 362:13–16.

    CAS  Google Scholar 

  • Avrahmi E, Weiss-Peretz J, Conn DF (1989) Epilepsy in patients with brain metastases triggered by intravenous contrast medium. Clin Radiol 40:422.

    Article  Google Scholar 

  • Belloni G, Bonaldi G, Monchini L (1988) Neurotossicità dei mezzi di contrasto iodati. Riv Neuroradiol 1:147–153.

    Google Scholar 

  • Bonnemain B, Meyer D, Schaefes M, et al. (1990) New iodinated, low-osmolar contrast media. A revised concept of hydrophilicity. Invest Radiol 25:S104–S106.

    CAS  Google Scholar 

  • Buchman AS, Klawans HL, Russell EJ (1987) Metrizamide and its neurological complications. Clin Neuropharmacol 10:1.

    Article  PubMed  CAS  Google Scholar 

  • Caillé JM, Allard M (1983) Neurotoxicity of hydrosoluble iodine contrast media. Invest Radiol 23(Suppl 1):S210.

    Google Scholar 

  • Caillé JM, Allard M (1988) Mezzi di contrasto in neuroradiologia. Riv Neuroradiol 1:129–138.

    Google Scholar 

  • Carchetti E, Baldassasare M, Penco T, Heonardi M (1988) Iopamidol 300-induced epilepsy. Intensive treatment and pathogenetic hypothesis. Neuroradiology 30:256.

    Google Scholar 

  • Castel JC, Dorcier F, Caillè JM (1987) Penetration of the brain by nonionic water soluble tri- and hexaiodinated contrast media. Experimental autoradiographic study of two contrast media: iotrol and iopamidol labelled with iodine 125. Neuroradiology 29:206–210.

    Article  PubMed  CAS  Google Scholar 

  • Corsico N, Tirone P (1988) Mezzi di contrasto iodurati ionici e non-ionici in neuroradiologia: aspetti farmaco-tossicologici. Riv Neuroradiol 1:155–159.

    Google Scholar 

  • Dunker RO, Harris AB, Jenkins DP (1976) Kinetics of horse¬radish peroxidase migration through cerebral cortex. Brain Res 118:199.

    Article  PubMed  CAS  Google Scholar 

  • Elkin C, Levan AMT, Leeds NE (1986) Tolerance of iohexol, iopamidol and metrizamide in lumbar myelography. Surg Neurol 26:542.

    Article  PubMed  CAS  Google Scholar 

  • Evill CA, Wilson AJ, Sage MR (1990) Chemotoxic effects of low-osmolar contrast media on the blood-brain barrier. Invest Radiol 25:S82–83.

    Article  PubMed  Google Scholar 

  • Facino RM, Raffaelli E, Pitre E (1979) Iopronic acid interaction with hepatic microsomal cytochrome P-450: relationship between chemical structure and binding. Pharmacol Res Commun 11:105–113.

    Article  PubMed  CAS  Google Scholar 

  • Floras P, Deliac P, Gross C, et al. (1990) Neurotoxicité de Plohexol vs Iopamidol dans la myélographie lombaire. Correlations clinique, électrophysiologique et tomodensitométrique. J Neuroradiol 17:190–200.

    PubMed  CAS  Google Scholar 

  • Giang DW, Kido DK (1989) Transient global amnesia associated with cerebral angiography performed with use of iopamidol. Radiology 172:195.

    PubMed  CAS  Google Scholar 

  • Hayakawa K, Yamashita K, Mitsumori M, Nakano Y (1990) Iodinated contrast media. In vivo quantification of the blood-brain barrier injury using magnetic resonance enhancement. Invest Radiol 25:S80–S81.

    Google Scholar 

  • Higgins CB, Schmidt WS (1979) Identification and evaluation of the contribution of the chemoreflex in the hemodynamic response to intracarotid administration of contrast materials in the conscious dog: comparison with the response to nicotine. Invest Radiol 14:438–446.

    Article  PubMed  CAS  Google Scholar 

  • Hoppe JO, Archer S (1960) X-ray contrast media for cardiovascular angiography. Angiology 11:244.

    Article  PubMed  CAS  Google Scholar 

  • Jeppson PG, Olin T (1970) Neurotoxicity of roentgen contrast media: study of the brain-blood barrier following selective injection of contrast media into the internal carotid artery. Acta Radiol 10:17–34.

    Google Scholar 

  • Junck L, Marshall WH (1983) Neurotoxicity of radiological contrast agents. Ann Neurol 13:469.

    Article  PubMed  CAS  Google Scholar 

  • Juni J, Morera J, et al. (1992) Transient global amnesia after cerebral angiography with iohexol. Neuroradiology 34: 141.

    Article  PubMed  CAS  Google Scholar 

  • Katayama H, Yamaguchi K, Kozuka T, et al. (1990) Adverse reactions to ionic and non-ionic contrast media. A report from Japanese Committee on the Safety of Contrast Media. Radiology 175:621.

    PubMed  CAS  Google Scholar 

  • La Noce A, Bertani F, Lorusso V, Luzzani F, Tirone P, De Haen C (1994) Preclinical safety assessment of iomeprol for injection as contrast medium for myelography. Eur J Radiol 18(Suppl 1):S43–S50.

    Article  PubMed  Google Scholar 

  • La Noce A, Lorenzon P, Pugliese F, et al. (1996) Brain penetration of intrathecal iomeprol in dogs. Acta Radiol 37:578–581.

    Article  PubMed  Google Scholar 

  • Lalli AF (1980) Contrast media reactions: data analysis and hypothesis. Radiology 134:1–12.

    PubMed  CAS  Google Scholar 

  • Lantos G (1989) Cortical blindness due to osmotic disruption of the blood-brain barrier by angiographic contrast material. CT and MRI studies. Neurology 39:567.

    CAS  Google Scholar 

  • Larsen LE, Heglund IF, Fabian R, et al. (1995) Neural tolerability of iodixanol in mice and dogs after single and repeated intracisternal administration. Acta Radiol (1995) 36(Suppl 399):238–243.

    Google Scholar 

  • Leonardi M, Lavaroni A, Bianizzo E, et al. (1989) High-dose contrast-enhanced computed tomography (CECT) with iopamidol in the detection of cerebral metastases. Tolerance of the contrast agent. Neuroradiology 31:148–150.

    CAS  Google Scholar 

  • Leonardi M, Auxilia F, Cosmacini G, Ottomano C (1995) Impiego degli esami ematochimici preliminari all’iniezione di mezzo di contrasto: è possibile rinunciarvi? Riv Neuroradiol 8:323–327.

    Google Scholar 

  • Levey AI, Weiss H, Yu R, Wang H, Krumholz A (1988) Seizures following myelography with iopamidol. Ann Neurol 23:397.

    Article  PubMed  CAS  Google Scholar 

  • Luzzani F, Morisetti A, Bussi S, Tirone P, De Haen C (1996) Neurotolerability of nonionic X-ray contrast media. Invest Radiol 31:338–344.

    Article  PubMed  CAS  Google Scholar 

  • Maly P, Sundgren P, Baath L, Golman K, Walday P (1995) Adverse reactions in myelography. Correlation between animal research and clinical practice. Acta Radiol 36 (Suppl 399):230–237.

    Google Scholar 

  • Marder E, O’Neil M, Grossman RI, et al. (1983) Cholinergic actions of metrizamide. AJNR 4:61–65.

    PubMed  CAS  Google Scholar 

  • Moschini M, Manara O, Bonaldi G, Cassinari V, Quilici N, Belloni G (1983) Iopamidol and metrizamide in cervical myelography: side effects, EEG and CSF changes. AJNR 4:848–850.

    PubMed  CAS  Google Scholar 

  • Nakstad P, Helgetveit A, et al. (1984) Iohexol compared to metrizamide in cervical and thoracic myelography. A randomized double blind parallel study. Neuroradiology 26:479.

    Article  PubMed  CAS  Google Scholar 

  • Palmer J (1990) Morbidity and mortality with intravenous contrast media ionic and nonionic. Invest Radiol 25:S18–S19.

    PubMed  Google Scholar 

  • Pullicino P, Kendall BE (1980) Contrast enhancement in ischaemic lesions: in relationship to prognosis. Neuroradiology 19:253–259.

    Google Scholar 

  • Rapoport ST, Levitan H (1974) Neurotoxicity of x-ray contrast media: relation to lipid solubility and blood-brain barrier permeability. Am J Roentgenol 122:186–193.

    CAS  Google Scholar 

  • Rapoport SI, Fredericks WR, Ohno K, Pettigrew KD (1980) Quantitative aspects of reversible osmotic opening of the blood-brain barrier. Am J Physiol 238:R421.

    PubMed  CAS  Google Scholar 

  • Rosati G (1994) Clinical utility and safety profile of iomeprol. Eur J Radiol 18(Suppl 1):S120–S124.

    Article  PubMed  Google Scholar 

  • Rosati G, Leto di Priolo S, Tirone P (1992) Serious or fatal complications after inadvertent administration of ionic water-soluble contrast media in myelography. Eur J Radiol 15:95–100.

    Article  PubMed  CAS  Google Scholar 

  • Sage MR, Wilcox J, Evill CA, Benness GT (1982) Comparison and evaluation of osmotic blood-brain barrier disruption following intracarotid mannitol and methylglucamine iothalamate. Invest Radiol 17:276–281.

    PubMed  CAS  Google Scholar 

  • Sage MR, Wilcox J (1983) Brain parenchyma penetration by intrathecal nonionic iopamidol. AJNR 4:1181–1183.

    PubMed  CAS  Google Scholar 

  • Sage MR, Turski PA, Levin A (1989) CNS imaging of the brain barrier. In: Neuwelt EA (ed) Implications of the blood-brain barrier and its manipulation. Plenum, New York, vol 2, Chap. 14.

    Google Scholar 

  • Schmidt RC (1980) Mental disorders after myelography with metrizamide and other water soluble contrast media. Neuroradiology 19:153.

    Article  PubMed  CAS  Google Scholar 

  • Scott WR (1980) Seizures. A reaction to contrast media for computed tomography of the brain. Radiology 137:359.

    PubMed  CAS  Google Scholar 

  • Speck U, Press WR, Mutzel W (1988) Osmolality-related effects of injections into the central nervous system. Invest Radiol 23(Suppl 1):S114–S117.

    PubMed  CAS  Google Scholar 

  • Tahta K, Ozgen T, Betker M, et al. (1993) Status epilepticus following iohexol myelography. Neuroradiology 35:322.

    CAS  Google Scholar 

  • Thomsen S, Dorph S (1993) High-osmolar and low-osmolar contrast media. An update on frequency of adverse drug reactions. Acta Radiol 34:205.

    Article  PubMed  CAS  Google Scholar 

  • Thomson KR, Wells DG, O’Brien K, Tomkins DC, Dixon RG (1990) Vertebral artery injections of methylglucamine diatrizoate, 60% iopromide, and iotrolan in the rabbit. Invest Radiol 25:S88–S89.

    PubMed  CAS  Google Scholar 

  • Torvik A, Wakday P (1995) Neurotoxicity of water-soluble contrast media. A review. Acta Radiol 36(Suppl 399):221–229.

    Google Scholar 

  • Vestergaard A, Dons K, Eskesen V, et al. (1991) Central nervous system reactions to cervical myelography. Acta Radiol 32:411.

    Article  PubMed  CAS  Google Scholar 

  • Whisson CC, Evill CA, Wilson AJ, et al. (1990) Muscular and central nervous system side effects of intracarotid contrast media in rabbits. Invest Radiol 25:S90–S91.

    Article  PubMed  CAS  Google Scholar 

  • Wilcox J, Wilson AJ, Evill CA, Sage MR (1987) A comparison of blood-brain barrier disruption by intracarotid iohexol and iodixanol in the rabbit. AJNR 8:769–772.

    PubMed  CAS  Google Scholar 

  • Zweifler RM, Rothrock JF (1995) Aseptic meningoencephalitis following iohexol myelography. Neuroradiology 37:148–149.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. M. Leonardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Agati
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Herlev Ringvei 75, DK-2730, Herlev, Denmark

    Henrick S. Thomsen MD

  2. Département de Chimie Organique & Laboratoire RMN, Université de Mons-Hainaut, 24, Avenue du Champ de Mars, B-7000, Mons, Belgium

    Robert N. Muller MD (Professor, Faculté de Médecine) (Professor, Faculté de Médecine)

  3. Department of Radiology, UCSD Medical Center, 200 W. Arbor Drive, 92109-8756, San Diego, CA, USA

    Robert F. Mattrey MD

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Leonardi, M., Agati, R. (1999). Neurotoxicity. In: Thomsen, H.S., Muller, R.N., Mattrey, R.F. (eds) Trends in Contrast Media. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59814-2_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59814-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64136-7

  • Online ISBN: 978-3-642-59814-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation