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Experimental Testing of Iodinated Contrast Media Before Human Testing

  • Chapter
Trends in Contrast Media

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

This chapter describes the testing of iodinated angio- and urographic x-ray contrast media before clinical testing. Once a promising series of chemical compounds has been conceived, a range of physicochemical and toxicological tests will be used to select the most promising candidate(s), which then will be subjected to a wider range of tests, including stability, pharmacokinetic, and toxicological tests, in order both to make the final choice and to predict its expected safety in man before clinical testing. After a new compound has been synthesized, and has been shown to be chemically stable, the major factor determining its suitability as a contrast agent is its toxicology. Much of this chapter is therefore devoted to aspects of toxicological testing.

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  1. Department of Experimental Research, Malmö University Hospital and Nycomed Innovation AB, Ideon-Malmö, S-205, 12 Malmö, Sweden

    R. Towart BSc, PhD & K. Golman PhD (Professor)

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  1. R. Towart BSc, PhD
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  1. Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Herlev Ringvei 75, DK-2730, Herlev, Denmark

    Henrick S. Thomsen MD

  2. Département de Chimie Organique & Laboratoire RMN, Université de Mons-Hainaut, 24, Avenue du Champ de Mars, B-7000, Mons, Belgium

    Robert N. Muller MD (Professor, Faculté de Médecine) (Professor, Faculté de Médecine)

  3. Department of Radiology, UCSD Medical Center, 200 W. Arbor Drive, 92109-8756, San Diego, CA, USA

    Robert F. Mattrey MD

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Towart, R., Golman, K. (1999). Experimental Testing of Iodinated Contrast Media Before Human Testing. In: Thomsen, H.S., Muller, R.N., Mattrey, R.F. (eds) Trends in Contrast Media. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59814-2_4

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