Adverse Reactions to Iodinated Radiographic Contrast Media

  • R. H. Cohan
  • J. H. Ellis
Part of the Medical Radiology book series (MEDRAD)


Mild adverse reactions to iodinated radiographic contrast media are encountered in as many as 3.7% of patients receiving intravenous injections of low-osmolality and 12.7% of patients receiving intravenous injections of high-osmolality ionic contrast agents (Katayama et al. 1990). Fortunately, the majority of these reactions are mild and clinically insignificant. Severe and very severe reactions (the latter requiring hospitalization) have been noted much less frequently, in only 0.04% and 0.004% of patients receiving intravenous injections of low-osmolality contrast media and 0.22% and 0.04% of patients receiving intravenous injections of high-osmolality contrast media, respectively (Katayama et al. 1990). The vast majority of patients who have severe, even potentially life-threatening, reactions respond to rapid and aggressive treatment (Hartman et al. 1982). Fatal reactions to both types of contrast media are exceedingly rare, having been encountered in as few as 1:170000 patients injected with either agent (Katayama et al. 1990).


Contrast Medium Nonionic Contrast Medium Autonomic Dysreflexia Idiosyncratic Reaction Ionic Contrast 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • R. H. Cohan
    • 1
  • J. H. Ellis
    • 1
  1. 1.Department of RadiologyUniversity of Michigan Medical CenterAnn ArborUSA

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