Assessment of Left Ventricular Function by Contrast Echo
Accurate and reproducible quantification of left ventricular (LV) function is a crucial component of clinical cardiology. LV function should be assessed in each cardiac patient. Earlier, research and development of diagnostic measures concentrated on systolic LV function, because diastole was thought to be a passive process, which is now known not to be the case. However, it is still easier to evaluate systolic than diastolic function. In the physiology lab, LV function is assessed using calculations derived from pressure and volume recordings; in clinical cardiology measurement of LIV wall motion has become the usual method for routine invasive and non-invasive diagnostics (1). We distinguish between global and regional systolic function; in order to assess global systolic LV function, quantification of end-diastolic and end-systolic volumes (LVED, LVES) and ejection fraction (EF) is essential. LV volume and ejection fraction are powerful prognostic measures in patients with coronary and valvular heart disease (2).
KeywordsLeft Ventricular Function Dobutamine Stress Echocardiography Left Ventricular Cavity Doppler Spectrum Endocardial Border
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- 1.Schiller NB, Shah PM, Crawford M et al. Recommendations for quantification of the left ventricle by 2-dimensional echocardiography; American Society of Echocardiography committee on standards, subcommittee on quantification of 2-dimensional echocardiograms. J Am Soc Echocardiogr 1989; 2: 358 – 367PubMedGoogle Scholar
- 5.Weyman AE,Franklin TD, Egenes KM et al. Correlation between extent of abnormal regional wall motion and myocardial infarct size in chronically infarcted dogs. Circulation 1997; 56: 72 – 78Google Scholar
- 12.Cohen JL, Cheirif J, Segar DS, Gillam LD, Gottdiener JS, Hausnerova E, Bruns DE. Improved left ventricular endocardial. border delineation and opacification with Optison, a new echocardiography contrast agent. Results of a Phase III multicenter trial. J Am Coll Cardiol 1998; 32 (3): 746 – 752PubMedCrossRefGoogle Scholar
- 15.Grayburn PA, Weiss JL, Hakc TC et al. Phase 3 multi center trial comparing the efficacy of 2% dodecafluoropentane emulsion (EchoGen) and sonicated 5% human albumin (Albunex) as ultrasound contrast agents in patients with suboptimal echo cardiograms. J Am Coll Cardiol 1998; 32: 230 – 236PubMedCrossRefGoogle Scholar
- 16.Mulvagh SL, Rainbird AJ, Al-Mansour HA et al. Harmonic dobutamine stress echocardiography: Does contrast make a difference in diagnostic feasability and accuracy? Circulation 1998; 12. 527Google Scholar
- 25.Burns, RN. (1995). Hemodynamics. In K. J. W Taylor, P N. Burns, & P. N. T. Wells (Eds.), Clinical Applications of Doppler Ultrasound (pp. 35 – 55 ). New York: Raven PressGoogle Scholar
- 26.Bezante G, Schwarz KQ, Chen X, Bertolazzi M, Spallarosa P, Villa G, Brunelli C. Automatic LV volume and ejection fraction by contrast harmonic color Doppler imaging compared to radionuclide ventriculography Eur Heart J 1999; 3628Google Scholar
- 27.Caiati C, Bina A, Zedda N et al. Contrast-enhanced harmonic colour Doppler reduces variability in assessing left ventricular volumes. Eur Heart J 1998; 19 (abstract supplement): 2350Google Scholar