Microfluidic Devices on Polymer Substrates for Bioanalytical Applications
Development of capabilities to miniaturize analytical devices and components offers a number of potential benefits. Among these are the ability to reduce sample sizes, development of low cost, single-use disposable devices, and improved device portability. Extensive work has been done on producing such microanalytical systems on silicon or glass substrates using processes commonly employed in electronic chip manufacturing [1–2]. For many analytical applications, however, common polymeric materials provide acceptable substrates from which to produce components or complete analytical systems [3–4]. The low flow rate characteristic of these microfluidic devices is compatible with the electrospray ionization/mass spectrometry (ESI-MS) [5–7]. In this paper, development of microfluidic analytical devices fabricated on polymer substrates using excimer laser micromachining technology will be described. These include a microfluidic motherboard, dual-stage microdialysis chip, and a micro capillary isoelectric focusing device. The applications of these micr ode vices for cleanup, fractionation, and separation of biological samples are discussed.
KeywordsAlbumin Polyethylene Syringe Fractionation Lamination
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