SAPHO Syndrome

  • Gerd Plewig
  • Albert M. Kligman


In 1987, Chamot et al. introduced the term SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteomyelitis) to designate a group of miscellaneous bone manifestations with or without dermatoses. The common factor in these cases was osteitis of the anterior chest wall. These bone lesions were sometimes combined with dermatoses such as pustulosis palmoplantaris, psoriasis, or acne. The skin lesions may precede or occur concurrently with or after the onset of skeletal complaints.


Bone Lesion Anterior Chest Wall Chronic Recurrent Multifocal Osteomyelitis Severe Acne Standard Treatment Regimen 
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  1. Chamot AM, Benhamou CL, Kahn MF, Beraneck L, Kaplan G, Prost A (1987) Le syndrome acne pustulose hyperostose osteite ( SAPHO ). Rev Rheumat 54: 187–196Google Scholar
  2. Grosshans EM (1993) SAPHO: the impossible acronym. Dermatology 186: 161–162PubMedCrossRefGoogle Scholar
  3. Kahn MF, Chamot AM (1992) SAPHO syndrome. Rheum Dis Clin North Am 18: 225–232Google Scholar
  4. Lehmann P, Specker C, von Schmiedeberg S (1999) SAPHO-Syndrom: nur ein schlechtes Akronym? In: Plewig G, Wolff H (eds) Fortschritte der praktischen Dermatologie und Venerologie, vol 16. Springer-Verlag, Berlin, pp 173–180Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Gerd Plewig
    • 1
  • Albert M. Kligman
    • 2
  1. 1.Klinik und Poliklinik für Dermatologie und Allergologie Klinikum MünchenLudwig-Maximilians-Universität MünchenMünchenGermany
  2. 2.Department of DermatologyUniversity of PennsylvaniaPhiladelphiaUSA

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