Skip to main content
SpringerLink
Log in

Introduction

  • Chapter
Penetrating Keratoplasty

  • 139 Accesses

Abstract

Complications following penetrating keratoplasty are caused by various pathomechanisms. Depending on preoperative diagnosis, both immunological and non-immunological problems are of importance. It is possible for them to occur simultaneously and mutually interact. Similar clinical pictures require precise and occasionally difficult differential diagnostic consideration. The resulting therapy, if begun early, may be crucial with regard to the course and final prognosis of the disorder.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alldredge OC, Krachmer JH (1981) Clinical types of Corneal transplant rejection. Their manifestations, frequency, preoperative correlates and treatment. Arch Ophthalmol 99:599–604

    PubMed  CAS  Google Scholar 

  2. Arentsen JJ (1983) Corneal transplant allograft reaction: possible predisposing factors. Trans Am Ophthalmol Soc 81:361–402

    PubMed  CAS  Google Scholar 

  3. Baggesen K, Ehlers N, Lamm LU (1991) HLA-DR/RFLP compatible Corneal grafts. Acta Ophthalmol (Copenh) 69:229–233

    Article  CAS  Google Scholar 

  4. Basu PX, Hasany SM, Ohashi K (1979) A Corneal model for studying the interaction between the endothelium and sensitized lymphocytes. Can J Ophthalmol 14 (1): 29–42

    PubMed  CAS  Google Scholar 

  5. Baun O, Gregersen E, Prause JU (1987) Irreversible immune reactions following keratoplasty. Acta Ophthalmol (Copenh) 65:641–647

    Article  CAS  Google Scholar 

  6. Boehnke M, Vogelberg K (1987) HLA-Antigene und Keratoplastik. Fortschr Ophthalmol 84:519–529

    Google Scholar 

  7. Boisjoly HM, Roy R, Dube I, Laughrea PA, Michaud R, Douville P, Hebert J (1986) HLA-A, B and DR matching in corneal transplantation. Ophthalmology 93:1290–1297

    PubMed  CAS  Google Scholar 

  8. Boisjoly HM, Bernard PM, Dube I, Laughrea PA, Bazin R, Bernier J (1989) Effect of factors unrelated to tissue matching on corneal transplant endothelial rejection. Am J Ophthalmol 107:647–654

    PubMed  CAS  Google Scholar 

  9. Boisjoly HM, Tourigny R, Bazin R, Laughrea PA, Dubé I, Chamber-land G, Bernier J, Roy R (1993) Risk Factors of Corneal Graft Failure. Ophthalmology 100:1728–1735

    PubMed  CAS  Google Scholar 

  10. Braude LS, Chandler JW (1983) Corneal allograft rejection. The role of the major histocompatibility complex. Surv Ophthalmol 27:290–305

    Article  PubMed  CAS  Google Scholar 

  11. Buxton JN, Schuman M, Pecego J (1981) Graft reactions after unilateral and bilateral keratoplasty for keratoconus Ophthalmology 88:771–773

    PubMed  CAS  Google Scholar 

  12. Chandler JW, Kaufman HE (1974) Graft reactions after keratoplasty for keratoconus. Am J Ophthalmol 77:543–547

    PubMed  CAS  Google Scholar 

  13. Chandler JW, Ray-Keil L, Gillette T (1983) Experimental corneal allograft rejection: description of murine model and a new hypothesis of immunopathogenesis. Curr Eye Res 2:387–397

    Article  CAS  Google Scholar 

  14. The Collaborative Corneal Transplantation Studies (CCTS) (1992) Effektiveness of histocompatibility matching in high-risk corneal transplantation. Arch Ophthalmol 110:1392–1403.

    Google Scholar 

  15. The Collaborative Corneal Transplantation Studies Research Group (1993) Design and methods of the collaborative corneal transplantation studies. Cornea 12(2):93–103

    Article  Google Scholar 

  16. Coster DJ (1981) Factors affecting the outcome of corneal transplantation. Ann R Coll Surg Engl 63:91–97

    PubMed  CAS  Google Scholar 

  17. Coster DJ, Williams KA (1989) Surgical manoeuvres to reduce the impact of corneal allograft rejection, Dev Ophthalmol 18:156–164

    PubMed  CAS  Google Scholar 

  18. Durand L, Burillon C (1990) Immunologie des greffes coméennes. Réaction de reject. In Durand L, Burillon C (Eds.): Complications de la chirurgie du segment anterieur. Masson; Paris, Milan, Barcelone, Mexico, pg. 362–374

    Google Scholar 

  19. El-Asrar AMA, Oordt JJ van den, Billiau A, Desmet V, Emarah MH, Missotten L (1989) Recombinant interferon-gamma induces HLA-DR expression on human corneal epithelial and endothelial cells in vitro: preliminary report. Br J Ophthalmol 73:587–590

    Article  PubMed  CAS  Google Scholar 

  20. Epstein RJ, Seedor JH, Dreizen NG et al. (1987) Penetrating keratoplasty for herpes simplex keratitis and keratoconus. Allograft rejection and survival. Ophthalmology 94:935–944

    PubMed  CAS  Google Scholar 

  21. Falcon MG (1989) Immunology of corneal transplantation. In: Lightman S (ed) Immunology of eye diseases. Kluwer Academic Publishers, Dodrecht Boston London. 3:41–60

    Google Scholar 

  22. Ferguson TA, Waldrep JC, Kaplan HJThe immune response and the eye. II. (1987) The nature of T suppressor cell induction in anterior chamber-associated immune deviation (ACAID). J Immunol. 139(2):352–7.

    PubMed  CAS  Google Scholar 

  23. Ficker LA, Kirkness CM, Rice NS, Steele AD (1988) Longterm prognosis for corneal grafting in herpes simplex keratitis. Eye 2:400–408

    Article  PubMed  Google Scholar 

  24. Fine M, Cignetti FE (1977) Penetrating keratoplasty in herpes simplex keratitis. Recurrence in Grafts. Arch Ophthalmol 95:613–616

    PubMed  CAS  Google Scholar 

  25. Foulks GN, Sanfilippo FP, Locascio JA 3d, MacQueen JM, Dawson DV (1983) Histocompatibility testing for keratoplasty in high-risk patients. Ophthalmology 90:239–244

    PubMed  CAS  Google Scholar 

  26. Fujikawa LS, Colvin RB, Bhan AK, Fuller TC, Foster CS (1982) Expression of HLA-A/B/C and -DR locus antigens on epithelial, stromal, and endothelial cells of the human cornea. Cornea 1:213–222

    Article  Google Scholar 

  27. Gibbs DC, Batchelor JR, Werb A, Schlesinger W, Casey TA (1974) The influence of tissue-type compatibility on the fate of full-thickness corneal grafts, Trans Ophthalmol Soc UK 94:101–126

    Google Scholar 

  28. Gillette TE, Chandler JW, Greiner J v (1982) Langerhans cells of the ocular surface. Ophthalmology 89:700–711.

    PubMed  CAS  Google Scholar 

  29. Girard LJ, Esnaola N, Rao R, Barnett L, Maghraby A el, Conizales R (1993) Allograft rejection after penetrating keratoplasty for keratoconus. Ophthalmic Surg 24(1):40–43

    PubMed  CAS  Google Scholar 

  30. Gronemeyer U, Westphal E, Böke W (1985) Prognostic value of histocompatibility testing in corneal grafting. A prospective study. Dev Ophthalmol 11:55–60

    PubMed  CAS  Google Scholar 

  31. Hill JC (1996) The relative importance of risk factors used to define high-risk keratoplasty. German Journal of Ophthalmology 5(1): 36–41

    PubMed  CAS  Google Scholar 

  32. Hirsch N, Nolle B, Zavazava N, Westphal E, Duncker G, Rocheis R, Müller-Ruchholtz W(1993) HLA-Typisierung bei Risikokeratoplastiken. Ophthalmologe 90:174–177

    PubMed  CAS  Google Scholar 

  33. Hoffmann F, Pahlitzsch T (1989) Predisposing factors in corneal graft rejection. Cornea 8:215–219

    Article  PubMed  CAS  Google Scholar 

  34. Hoffmann F, Keyserlingk HJ von, Wiederholt M (1988) Bedeutung der Transplantationsantigene für die Keratoplastik. Fortschr Ophthalmol 85:186–189

    PubMed  CAS  Google Scholar 

  35. Hoffmann F, Tregel M, Noske W, Buente S (1994) HLA-B and -DR match reduces the allograft reaction after keratoplasty, German Journal of Ophthalmology. 3(2)100–4

    PubMed  CAS  Google Scholar 

  36. Holland JE, DeRuyter DN, Doughman DJ (1987) Langerhans cells in organ cultured corneas. Arch Ophthalmol 105:542–545

    PubMed  CAS  Google Scholar 

  37. Khodadoust AA, Karnema V (1984) Corneal grafts in the second eye. Cornea 3:17–20

    Article  PubMed  CAS  Google Scholar 

  38. Khodadoust AA, Silverstein AM (1969) Transplantation and rejection of individual cell layers of the cornea. Invest Ophthalmol Vis Sci 8:180–195

    CAS  Google Scholar 

  39. Khodadoust AA, Silverstein AM (1972) Studies on the nature of the privilege enjoyed by corneal allografts. Invest Ophthalmol Vis Sci 11:137–148

    CAS  Google Scholar 

  40. Khodadoust AA, Silverstein AM (1975) Local graft versus host reactions within the anterior chamber of the eye: the formation of corneal endothelial pocks. Invest Ophthalmol Vis Sci 14:640–647

    CAS  Google Scholar 

  41. Khodadoust AA, Silverstein AM (1976) Induction of corneal graft rejection by passive cell transfer. Invest Ophthalmol Vis Sci 15:89–95

    CAS  Google Scholar 

  42. Kok-van Alphen CC, Völker-Dieben HJ (1978) Über Abstoßungsreaktion des Korneatransplantats und die ersten Versuche mit gewebetypisiertem und HLA-angepaßtem Spendermaterial. Klin Monatsbl Augenheilkd 173:208–214

    PubMed  CAS  Google Scholar 

  43. Kok-van Alphen CC, Völker-Dieben HJ, D’Amaro J (1987) Die Ergebnisse von HLA-Typisierung bei der Hornhauttransplantation. Fortschr Ophthalmol 84:42–45

    PubMed  CAS  Google Scholar 

  44. Kok-van Alphen CC, Völker-Dieben HJ, D’Amaro J (1987) When is a tissue- typed cornea necessary? Doc Ophthalmol 67:73–81

    Article  PubMed  CAS  Google Scholar 

  45. Krachmer JH, Alldredge OC (1978) Subepithelial infiltrates. A probable sign of corneal transplant rejection. Arch Ophthalmol 96:2234–2237

    PubMed  CAS  Google Scholar 

  46. Lomholt J A, Baggesen K, Ehlers N (1995) Recurrence and rejection rates following corneal transplantation for herpes simplex. Acta Ophthalmol (Copenh) 73:29–32

    CAS  Google Scholar 

  47. Malbran ES, Fernandez-Meijide RE (1982) Bilateral versus unilateral penetrating graft in keratoconus. Ophthalmology 89:38–40

    PubMed  CAS  Google Scholar 

  48. Martin XD, Ganzfried R (1990) Keratoplasties a risque, antigènes HLA et cyclosporin-A (At-risk keratoplasty, HLA antigens and cyclosporin-A.) Klin Monatsbl Augenheilkd 196:301–303

    Article  PubMed  CAS  Google Scholar 

  49. Maumenee AE (1951) The influence of donor-recipient sensitization on corneal grafts. Am J Ophthalmol 34:142–152

    PubMed  CAS  Google Scholar 

  50. Mayer DJ (1986) Tissue Typing. Present state of the art and results. In: Brightbill FS (ed). Corneal surgery. Mosby Company, St. Louis, MO, pp 158–162

    Google Scholar 

  51. Musch DC, Meyer RF (1989) Risk of endothelial rejection after bilateral penetrating keratoplasty. Ophthalmology 96:1139–1143

    PubMed  CAS  Google Scholar 

  52. Niederkorn JY, Peeler JS (1988) Regional differences in immune regulation: The immunogenic privilege of corneal allografts. Immunol Res 7:247–255

    Article  PubMed  CAS  Google Scholar 

  53. Niederkorn JY (1990) Immune privilege and immune regulation in the eye. Adv Immunol. 48:191–226.

    Article  PubMed  CAS  Google Scholar 

  54. Paufique L, Sourdille GP, Offret G (1948) Les greffes de la cornée. Masson et Cie. Editeurs, Paris, pp 131–136

    Google Scholar 

  55. Pels E, Feiten P (1987) HLA-Class I antigens on human cornai endothelium. Ophthalmic Res 19:26

    Google Scholar 

  56. Pels E, Gaag R von der (1985) HLA-A,B,C and HLA-DR antigens and dendritic cells in fresh and organ culture preserved corneas. Cornea 3:231–239

    CAS  Google Scholar 

  57. Pepose JS, Gardner KM, Nestor MS, Foos RY, Pettit TH (1985) Detection of HLA class I and II antigens in rejected human corneal allografts. Ophthalmology 92:1480–1484

    PubMed  CAS  Google Scholar 

  58. Pleyer U, Rieck P, Ritter T, Hartmann C (1998) Immune reaction after penetrating keratoplasty. II. Prevention and therapy. Ophthalmologe 95(6):444–59

    Article  PubMed  CAS  Google Scholar 

  59. Pleyer U, Thiel HJ (1995) Cytotoxic mechanisms in corneal allograft rejection. In Pleyer U, Schmidt K, Thiel HJ (Eds.) New strategies in the prevention and therapy. Hippokrates, Stuttgart, pg. 71–85

    Google Scholar 

  60. Pleyer U, Weidle EG, Lisch W, Steuhl KP, Moehrle C, Richter U, Zierhut M, Selbmann HK (1990) Klinische Verlaufsformen immunologischer Transplantatreaktion nach perforierender Keratoplastik. Fortschr Ophthalmol 87:14–19

    PubMed  CAS  Google Scholar 

  61. Polack FM (1975) The corneal host-graft junction. Physiopathology of the scar. Arch Ophthalmol 35:139–152

    CAS  Google Scholar 

  62. Polack FM (1977) The healing of corneal grafts. In: Polack FM (ed) Corneal transplantation. Grune & Stratton, London, pp 45–69

    Google Scholar 

  63. Polack FM, Binder PS (1975) Detachment of descemet’s membrane from grafts following wound separation: light and scanning electron microscopic study. Ann Ophthalmol 7:47–54

    PubMed  CAS  Google Scholar 

  64. Polack FM, Kaufmann HE (1972) Penetrating keratoplasty in herpes keratitis. Am J Ophthalmol 73:908–913

    PubMed  CAS  Google Scholar 

  65. Polack F, Siverio C, Bigar F, Centifanto Y (1976) Immune host response to corneal grafts sensitized to herpes simplex virus. Invest Ophthalmol Vis Sci 15:188–195

    CAS  Google Scholar 

  66. Price FW, Whitson WE, Collins KS, Marks RG (1993) Five year corneal graft survival. A large single-center patient cohort. Arch Ophthalmol 111:799–805

    PubMed  Google Scholar 

  67. Sanfilippo F, Foulks GN (1989) The role of histocompatibility in human corneal transplantation. Transplant Proc 21:3127–3129

    PubMed  CAS  Google Scholar 

  68. Sanfilippo F, MacQueen JM, Vaughn WK, Foulks GN (1986) Reduced graft rejection with good HLA-A and B matching high-risk corneal transplantation. N Engl J Med 315:29–35

    Article  PubMed  CAS  Google Scholar 

  69. Severin M (1986) Immunreaktionen nach Keratoplastik. Klin Monatsbl Augenheilkd 188:200–208

    Article  PubMed  CAS  Google Scholar 

  70. Smolin G, Goodman D (1988) Corneal graft reaction. Int Ophthalmol Clin 28:30–36

    Article  PubMed  CAS  Google Scholar 

  71. Sterk CC, Jager MJ, Swart-v.d. Berg M (1995) Recurrent herpetic keratitis in penetrating keratoplasty. Documenta Ophthalmologica, 90(1):29–33

    Article  PubMed  CAS  Google Scholar 

  72. Sundmacher R (1985) The role of donor epithelium in perforating keratoplasty. Dev Ophthalmol 11:61–67

    PubMed  CAS  Google Scholar 

  73. Szymankiewicz M, Weidle EG, Thiel HJ (1987) Klinik, Verlauf und Ergebnisse der Keratoplastik à chaud. Fortschr Ophthalmol 84:506–509

    PubMed  CAS  Google Scholar 

  74. Tagawa Y, Silverstein AM, Prendergast RA (1982) Mechanisms of allograft rejection of corneal endothelium. Invest Ophthalmol Vis Sci 23:32–40

    PubMed  CAS  Google Scholar 

  75. Thiel HJ, Manthey KF (1980) Die Häufigkeit von Immunreaktionen nach perforierenden Keratoplastiken. Klin Monatsbl Augenheilkd 177:274–283

    Article  PubMed  CAS  Google Scholar 

  76. Treseler PA, Sanfilippo F (1986) Relative contribution of major histocompatibility complex antigens to the immunogenecity of corneal allografts. Transplantation 41:508–514

    Article  PubMed  CAS  Google Scholar 

  77. Thuft SJ, Gregory WM, Davison CR (1995) Bilateral penetrating keratoplasty for keratoconus. Ophthalmology, 102(3) 462–8

    Google Scholar 

  78. Völker-Dieben HJ, Kok-van Alphen CC, Kruit PJ (1979) Advances and disappointments, indications and restrictions regarding HLA-matched corneal grafts in high risk cases. Doc Ophthalmol 46:219–226

    Article  PubMed  Google Scholar 

  79. Völker-Dieben HJ, Kok-van Alphen CC, Landsbergen Q, Persijn GG (1982) Different influences on corneal graft survival in 539 transplants. Acta Ophthalmol 60:190–202

    Google Scholar 

  80. Völker-Dieben HJ, Kok-van Alphen CC, D’Amaro J, Lange P de (1984) The effect of prospective HLA-A and -B matching in 288 penetrating keratoplasties for herpes simplex keratitis. Acta Ophthalmol 62:513–523

    Google Scholar 

  81. Völker-Dieben HJ, D’Amaro J, Kok-van Alphen CC (1987) Hierarchy of prognostic factors for corneal allograft survival. Aust N Z J Ophthalmol 15:11–18

    Article  PubMed  Google Scholar 

  82. Völker-Dieben HJ, D’Amaro J, Kruit PJ, Lange P de (1989) Interaction between prognostic factors for corneal allograft survival. Transplant Proc 21:3135–3138

    PubMed  Google Scholar 

  83. Wilbanks GA, Streilein JW (1991) Studies on the induction of anterior chamber-associated immune deviation (ACAID). 1. Evidence that an antigen-specific, ACAID-inducing, cell-associated signal exists in the peripheral blood. J Immunol. 146(8):2610–7

    PubMed  CAS  Google Scholar 

  84. Williams KA, Ash KJ, Coster D (1985) Histocompatibility antigen and passenger cell content of normal and diseased human cornea. Transplantation 39:265–269

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zentrum für Augenheilkunde, Universität Köln, Joseph-Stelzmann-Straße 9, 50931, Köln, Germany

    Dr. Maria Severin & PD Dr. Karl Ulrich Bartz-Schmidt

Authors
  1. Dr. Maria Severin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. PD Dr. Karl Ulrich Bartz-Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Severin, M., Bartz-Schmidt, K.U. (2000). Introduction. In: Penetrating Keratoplasty. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59684-1_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59684-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64083-4

  • Online ISBN: 978-3-642-59684-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation