Clinical and Neuropathological Features in AIDS Patients with Progressive Multifocal Leukoencephalopathy (PML) Including a Novel Approach by in situ PCR
Opportunistic infection of the central nervous system by human Polyomavirus JC (JCV) can cause a devastating disease, progressive multifocal leukoencephalopathy (PML). We reviewed the clinical features of 15 patients with acquired immune deficiency syndrome (AIDS) and PML who came to autopsy or biopsy between 1983 and 1990, and investigated brain tissue with conventional and modern molecular biology techniques.
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