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Einflußgrößen auf den Krankheitsverlauf der HIV-Infektion — Serokonverterstudie

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HIV-Infekt

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Zusammenfassung

Die HIV-Infektion ist gekennzeichnet durch einen chronischen Infektionsverlauf mit jedoch individuell sehr unterschiedlicher Dauer vom Zeitpunkt der Infektion bis zum Auftreten AIDS-defìnierender Krankheitssymptome und bis zum Tod. Insbesondere die Einführung neuer Therapien in den letzten Jahren aber auch andere Einflußgrößen, wie z. B. neue Virusvarianten könnten eine Veränderung der Verteilung der Inkubations- bzw. Überlebenszeiten bedingen. Für das Verständnis des natürlichen Krankheitsverlaufes, die Beurteilung der zukünftigen Entwicklung der HIV/AIDS-Epidemie und die Evaluation von neuen Therapien ist es von großer Bedeutung, das Ausmaß dieser Änderung und die entsprechenden Einflußfaktoren zu erkennen.

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Literatur

  1. Alcabes P, Pezzotti P, Phillips AN, Rezza G, Vlahov D (1997) Long-term perspective on the prevalent-cohort biases in studies of human immunodeficiency virus progression. American Journal of Epidemiology 146: 543–551

    PubMed  CAS  Google Scholar 

  2. Biggar RJ, and the International Registry of Seroconverters (1990) AIDS incubation in 1891 HIV seroconverters from different exposure groups. AIDS 4: 1059–1066

    Google Scholar 

  3. Brettle RP, McNeil AJ, Burns S et al. (1996) Progression of HIV: follow-up of Edinburgh injecting drug users with narrow seroconversion intervals in 1983–1985. AIDS 10: 419–430

    Article  PubMed  CAS  Google Scholar 

  4. Brookmeyer R, Gail MH, Polk BF (1987) The prevalent cohort study and the acquired immunodeficiency syndrome. American Journal of Epidemiology 126: 14–24

    PubMed  CAS  Google Scholar 

  5. Carré N, Deveau C, Belanger F et al. (1994) Effect of age and exposure group on the onset of AIDS in heterosexual and homosexual HIV-infected patients. AIDS 8: 797–802

    Article  PubMed  Google Scholar 

  6. Carré N, Prins M, Meyer L et al. (1997) Has the rate of progression to AIDS changed in recent years? AIDS 11: 1611–1618

    Article  PubMed  Google Scholar 

  7. Cox DR (1972) Regression models and life-tables. Journal of the Royal Statistical Society (Series B) 34: 187–202

    Google Scholar 

  8. Darby SC, Ewart DW, Giangrande PLF, Spooner RJD, Rizza CR (1996) Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population. The Lancet 347: 1573–1579

    CAS  Google Scholar 

  9. Flandre P, Boufassa F, Gerard L, Carré N, Persoz A, Meyer L (1996) The use of auxiliary events to improve the analysis of survival for HIV-infected patients: Application to the French Prospective Multicenter Cohort ( SEROCO ). Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 12: 174–181

    Article  PubMed  CAS  Google Scholar 

  10. Goedert JJ, Kessler CM, Aledort LM et al. (1989) A prospective study of Human Immunodeficiency Virus type 1 infection and the development of AIDS in subjects with hemophilia. The New England Journal of Medicine 321: 1141–1148

    Article  PubMed  CAS  Google Scholar 

  11. Holman RC, Gomperts ED, Jason JM, Abildgaard CF, Zelasky MT, Evatt BL (1990) Age and human immunodeficiency virus infection in persons with hemophilia in California. American Journal of Public Health 80: 967–969

    Article  PubMed  CAS  Google Scholar 

  12. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. Journal of the Americal Statistical Association 53: 457–481

    Article  Google Scholar 

  13. Keet IPM, Krijnen P, Koot M et al. (1993) Predictors of rapid progression to AIDS in HIV-1 seroconverters. AIDS 7: 51–57

    Article  PubMed  CAS  Google Scholar 

  14. Pedersen C, Katzenstein T, Nielsen C, Lundgren JD, Gerstoft J (1997) Prognostic value of serum HIV-RNA levels at virologie steady state after seroconversion: Relation to CD4 cell count and clinical course of primary infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 16: 93–99

    Article  PubMed  CAS  Google Scholar 

  15. Pezzotti P, Rezza G, Lazzarin A et al. (1992) Influence of gender, age, and transmission category on the progression from HIV seroconversion to AIDS. Journal of Acquired Immune Deficiency Syndromes 5: 745–747

    PubMed  CAS  Google Scholar 

  16. Phillips AN, Lee CA, Elford J et al. (1991) More rapid progression to AIDS in older HIV-infected people: The role of CD4+ T-cell counts. Journal of Acquired Immune Deficiency Syndromes 4: 970–975

    PubMed  CAS  Google Scholar 

  17. Prins M, Veugelers PJ (1997) Comparison of progression and non-progression in injecting drug users and homosexual men with documented dates of HIV-1 seroconversion. AIDS 11: 621–631

    Article  PubMed  CAS  Google Scholar 

  18. Ragni MV, Kingsley LA (1990) Cumulative risk for AIDS and other HIV outcomes in a cohort of hemophiliacs in Western Pennsylvania. Journal of Acquired Immune Deficiency Syndromes 3: 708–713

    PubMed  CAS  Google Scholar 

  19. Rosenberg PS, Goedert JJ, Biggar RJ (1994) Effects of age at seroconversion on the natural AIDS incubation distribution. AIDS 8: 803–810

    Article  PubMed  CAS  Google Scholar 

  20. Santagostino E, Gringeri A, Cultraro D et al. (1995) Factors associated with progression to AIDS and mortality in a cohort of HIV-infected patients with hemophilia followed up since seroconversion. Cellular and Molecular Biology 41: 371–380

    PubMed  CAS  Google Scholar 

  21. Schinaia N, Ghirardini A, Chiarotti F, Gringeri A, Mannucci PM (1991) Progression to AIDS among Italian HIV-seropositive haemophiliacs. AIDS 5: 385–391

    Article  PubMed  CAS  Google Scholar 

  22. Spijkerman U, Langendam MW, Veugelers PJ et al. (1996) Differences in progression to AIDS between injection drug users and homosexual men with documented dates of seroconversion. Epidemiology 7: 571–577

    Article  PubMed  CAS  Google Scholar 

  23. Touloumi G, Hatzakis A, Rosenberg PS, O’Brien TR, Goedert JJ (1998) Effects of age at seroconversion and baseline HIV RNA level on the loss of CD4+ cells among persons with hemophilia. AIDS 12: 1691–1697

    Article  PubMed  CAS  Google Scholar 

  24. Touloumi G, Karafoulidou A, Gialeraki A et al. (1998) Determinants of progression of HIV infection in a Greek hemophilia cohort followed for up to 16 years after seroconversion. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 19: 89–97

    Article  PubMed  CAS  Google Scholar 

  25. UK Register of HIV Sero converters Steering Committee (1998) The AIDS incubation period in the UK estimated from a national register of HIV seroconverters. AIDS 12: 659–667

    Google Scholar 

  26. Veugelers PJ, Page KA, Tindall B et al. (1994) Determinants of HIV disease progression among homosexual men registered in the Tricontinental Seroconverter Study. American Journal of Epidemiology 140: 747–758

    PubMed  CAS  Google Scholar 

  27. Veugelers PJ, Strathdee SA, Kaldor JM et al. (1997) Associations of age, immunosuppression, and AIDS among homosexual men in the Tricontinental Seroconverter Study. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 14: 435–441

    Article  PubMed  CAS  Google Scholar 

  28. Veugelers PJ, Strathdee SA, Tindall B et al. (1994) Increasing age is associated with faster progression to neoplasms but not opportunistic infections in HIV-infected homosexual men. AIDS 8: 1471–1475

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. Brunn
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  2. D. Altmann
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  3. O. Hamouda
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  4. C. Kücherer
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Editor information

Editors and Affiliations

  1. Klinik für Dermatologie, Allergologie und Venerologie, Ruhr-Universität Bochum, Gudrunstraße 56, Deutschland

    Norbert H. Brockmeyer , Klaus Hoffmann , G. Reimann , Markus Stücker  & Peter Altmeyer , , ,  & 

  2. Medizinische Klinik III, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Deutschland

    R. Brodt

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© 2000 Springer-Verlag Berlin Heidelberg

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Brunn, M., Altmann, D., Hamouda, O., Kücherer, C. (2000). Einflußgrößen auf den Krankheitsverlauf der HIV-Infektion — Serokonverterstudie. In: Brockmeyer, N.H., Hoffmann, K., Reimann, G., Stücker, M., Altmeyer, P., Brodt, R. (eds) HIV-Infekt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59683-4_23

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  • DOI: https://doi.org/10.1007/978-3-642-59683-4_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64082-7

  • Online ISBN: 978-3-642-59683-4

  • eBook Packages: Springer Book Archive

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