Abstract
The in vitro activity of moxifloxacin [Bay 12-8039], a new 8-methoxy-quinolone, against anaerobic bacteria was reviewed and compared to that of other fluoroquinolones such as ciprofloxacin, levofloxacin, ofloxacin and sparfloxacin. Moxifloxacin has a broad spectrum of activity against anaerobic bacteria, usually has an MIC90 2 µg/mL against most species, was more potent than levofloxacin and ciprofloxacin and was effective against most clinically important anaerobic pathogens. It had a similar spectrum of activity and MIC patterns in comparison with trovafloxacin. The fusobacteria were relatively resistant to all the fluoroquinolones. Extrapolating from the in vitro data, moxifloxacin may be effective against skin and soft tissue infections caused by human and animal bites, and has potential for clinical use in respiratory tract infection, abdominal surgical and gynaecological infections. Clinical evaluation in mixed aerobic/ anaerobic infections appears warranted.
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Goldstein, E. (2000). In-vitro Activity of Moxifloxacin [Bay 12-8039], an 8-methoxy Quinolone, Compared to Other Fluoroquinolones Against Anaerobic Bacteria. In: Mandell, L. (eds) First International Moxifloxacin Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59681-0_9
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DOI: https://doi.org/10.1007/978-3-642-59681-0_9
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