Abstract
Abstract. Moxifloxacin is an 8-methoxy quinolone. This structure is believed to confer reduced phototoxicity. Moxifloxacin was investigated in 32 healthy human male volunteers using a randomised, double-blind placebo and positive control (lomefloxacin) phototest study.
Baseline and on-drug photosensitivity was determined across the ultraviolet/visible wavebands using a differentiation grating monochrometer. Placebo and moxifloxacin (200 or 400 mg/day) regimen failed to demonstrate phototoxicity. Lomefloxacin (400 mg/day) revealed significant UVA (335 − 365 ± 30 nm) dependent phototoxicity with a phototoxic index of 3–4. This effect rapidly normalised within 48 hours of stopping the drug. No photoprotective measures appear necessary while taking moxifloxacin (200 or 400 mg/day).
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© 2000 Springer-Verlag Berlin Heidelberg
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Ferguson, J. (2000). Fluoroquinolone Phototoxicity — Moxifloxacin in Context. In: Mandell, L. (eds) First International Moxifloxacin Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59681-0_25
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DOI: https://doi.org/10.1007/978-3-642-59681-0_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64081-0
Online ISBN: 978-3-642-59681-0
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