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Primates in the Experimental Pharmacology of Obesity

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Obesity: Pathology and Therapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 149))

Abstract

Obesity in monkeys is a disease of maturity, with no reports to date of spontaneous juvenile onset obesity in any primate species. Monkeys are sexually mature at about the age of 4 years, and continue increasing in lean body mass and growth to about 7 years. From 7 years on some monkeys spontaneously and gradually develop excess body fatness, while others, maintained under identical conditions, remain lean all their lives. Interestingly, this adult-onset obesity develops while monkeys are being maintained on ad libitum feeding of a diet which is “ideal” in composition - low in fat, negligible in cholesterol, reasonable in protein, and high in fiber. The usual chow diet contains about 13% of calories as fat, 18% as protein, and 69% as digestible carbohydrates, with cholesterol content of about 83mg/kg diet. Composition of the diet is, therefore, not a significant factor in the development of spontaneous adult onset obesity in non-human primates. Obesity develops in free ranging monkeys (SCHWARTZ et al. 1993), of both sexes (SCHWARTZ et al. 1992), as well as in those maintained in a laboratory environment (JEN et al. 1985; KEMNITZ et al. 1986; HAMILTON et al. 1978).

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Authors
  1. B. C. Hansen
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Editors and Affiliations

  1. Department of Clinical Research, Parke-Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA

    Dean H. Lockwood M.D. (Vice President) (Vice President)

  2. Neuroscience Therapeutics, Parke-Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA

    Thomas C. Heffner Ph.D. (Sr. Director) (Sr. Director)

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© 2000 Springer-Verlag Berlin Heidelberg

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Hansen, B.C. (2000). Primates in the Experimental Pharmacology of Obesity. In: Lockwood, D.H., Heffner, T.C. (eds) Obesity: Pathology and Therapy. Handbook of Experimental Pharmacology, vol 149. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59651-3_18

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  • DOI: https://doi.org/10.1007/978-3-642-59651-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64070-4

  • Online ISBN: 978-3-642-59651-3

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