Erythropoietin Use in Therapy of Anemia Associated with Bone Marrow Transplantation in Children
Erythropoietin (EPO) is a hematopoietic growth factor that plays a vital role in erythropoiesis regulating the red blood cell synthesis. EPO is a hormone-like glycoprotein (molecular weight 24 000 daltons) that regulates the red blood cell synthesis and the proliferation and maturation of erythroid cells in bone marrow . Its concentration is related to the degree of anemic hypoxia. Recombinant DNA technology has permitted the production of sufficient amounts of recombinant human EPO (rhEPO) for clinical application . Endogenous EPO production becomes inadequate in most recipients of megachemotherapy and bone marrow transplantation 2–3 weeks after transplantation. During this time, erythrocyte transfusions are required . Recombinant EPO, which was first successfully applied in anemic patients with chronic renal failure, is increasingly being used to treat chronic anemia in cancer and patients after BMT [4,7,9,10,11,15].
KeywordsPlacebo Leukemia Anemia Erythropoietin Allo
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