Erythropoietin Use in Therapy of Anemia Associated with Bone Marrow Transplantation in Children

  • A. Chybicka
  • E. Gorczynska
  • J. Boguslawska-Jaworska
  • D. Kurpas


Erythropoietin (EPO) is a hematopoietic growth factor that plays a vital role in erythropoiesis regulating the red blood cell synthesis. EPO is a hormone-like glycoprotein (molecular weight 24 000 daltons) that regulates the red blood cell synthesis and the proliferation and maturation of erythroid cells in bone marrow [1]. Its concentration is related to the degree of anemic hypoxia. Recombinant DNA technology has permitted the production of sufficient amounts of recombinant human EPO (rhEPO) for clinical application [2]. Endogenous EPO production becomes inadequate in most recipients of megachemotherapy and bone marrow transplantation 2–3 weeks after transplantation. During this time, erythrocyte transfusions are required [3]. Recombinant EPO, which was first successfully applied in anemic patients with chronic renal failure, is increasingly being used to treat chronic anemia in cancer and patients after BMT [4,7,9,10,11,15].


Bone Marrow Transplantation Autologous Bone Marrow Transplantation Hematopoietic Growth Factor Chronic Anemia Recombinant Erythropoietin 
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© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • A. Chybicka
    • 1
  • E. Gorczynska
    • 1
  • J. Boguslawska-Jaworska
    • 1
  • D. Kurpas
    • 1
  1. 1.Department of Children’s Hematology and OncologyWroclaw University of MedicineWroclawPoland

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