Zusammenfassung
Etwa 15% der deutschen Bevölkerung sind mehr als 60 Jahre alt. Die mittlere Lebenserwartung in Deutschland beträgt bei Frauen gegenwärtig 78,7 Jahre, bei Männern 72,2 Jahre. Der Anteil der über 60jährigen in der Bevölkerung hat seit 1910 um das Dreifache zugenommen. Demographischen Prognosen zufolge wird er im Jahre 2000 25% und 35% im Jahre 2030 betragen [2]. Die zunehmende Lebenserwartung und die sich ständig ausweitenden diagnostischen und therapeutischen Möglichkeiten stellen die Medizin vor spezielle Probleme beim älteren Patienten (s. a. Kapitel 1). Das trifft für die Gastroenterologie und Hepatologie in besonderem Maße zu. Aus physiologischer Sicht geht das Altern mit einer zunehmenden Einschränkung organspezifischer Reserveleistungen einher. Diese Einschränkung wird jedoch nur in außergewöhnlichen Belastungssituationen erkennbar, ist aber ansonsten symptom-und folgenlos. Aber sie kann beim alten Menschen dazu führen, daß Erkrankungen früher symptomatisch werden als bei Jüngeren. Bereits heute entfallen auf die knapp 20% der über 60jährigen etwa 50% aller rezeptpflichtigen Medikamentenverordnungen. Auch die Zahl der verordneten Medikamente nimmt zu. Ältere Patienten erhalten im Krankenhaus durchschnittlich 4,6 Medikamente täglich, ambulant behandelte 3,2 (s. a. Kapitel 1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Holt PR (1995) Approach to gastrointestinal problems in the elderly. In: Yamada T(ed) Textbook of gastroentology, 2ne edn, vol. 2 Loppincott, Philadelphia. In: 968–988
Müller-Stein M, Lauter h (1988) Soziale Betreuung im höheren Lebensalter. In: Hippius H, Lauter H, Greil W (Hrsg) Psychiatrie für die Praxis, Bd 8: Psychische Störungen im höheren Lebensalter. MMV, München, S 68–74
Literatur
Adam R, Astarcioglu I, Azoulay D, Chiche L, Bao YM, Bastaing D, Bismuth H (1993) Liver transplantation from elderly donors. Transplant Proc 25: 1556–1557
Aleyander JV, Vaughn WK, Cadrey MA (1991) The use of marginal donors for organ transplantation: The older and younger donors. Transplant Proc 23: 905–907
Birnbaum L, Baird M (1978) Induction of hepatic mixed function oxidases in senescent rodents. Exp Gerontol 4: 299–303
Boyd WP (1989) Hepatobiliary disorders in geriatric gastroenterology. In: Sodeman WA, Saladin TA, Boyd WP (eds). Philadelphia, Saunders, p 193
Brouwer A, Barelds R, Knook DL (1985) Age-related changes in the capacity of rat liver Kupffer and endothelial cells. Hepatology 5: 362
Buckel E, Sanchez-Urdaspal L, Steers J, Sterioff S, Wiesner R, Krom RAF (1993) Impaired initial function in liver grafts from donors >50 years of age. Transplant Proc 25: 1558–1559
Burns EA, Goodwin JS (1990) Immunology and infections. In: Cassel CK, Riesenberg DE, Sorensen LB, Walsh JR (eds) Geriatric Medicine, 2nd edn. Springer, Berlin Heidelberg New York Tokyo, pp 312–329
Castleden CM, George CF, Marcer D et al. (1977) Increased sensitivity to nitrazepam in old age. BMJ 1: 10
Crowley JJ, Cusack BJ, Jue SG et al. (1988) Aging and drug interactions. II. Effects of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men. J Pharmacol Exp Ther 245: 513–523
Cusack BK, Nielson CP, Vestal RE (1996) Geriatric clinical pharmacology and therapeutics. In: Speight TM, Holford NHG (eds) Avery‘s drug treatment, 4th edn, pp 173–224
David H, Peinke P (1988) Liver morphology with aging. In: Bianchi L et al. (eds) Aging in liver and gastrointestinal tract. MTP, Lancester, pp 143–159
Davis GL (1998) Hepatitis C: Therapy. In: Hepatitis A to F: An update AASLD Postgraduate Course pp 246–256
Dimopoulou M, Fafoutis K, Basiliou K, Ketikoglou J, Karvountzins G (1993) Interferon alfa-2b for decompensated liver disease caused by either chronic hepatitis B or C: Preliminary results of a pilot study. Gut 34 [Suppl 2]: S104–105
Durnas C, Loi C-M, Cusack BJ (1990) Hepatic drug metabolism and aging. Clin Pharmacokinet 19: 349
Emre S, Mor E, Schwartz ME, Katz E, Acarli K, Fukuzawa K, Miller CM (1993) Liver transplantation in patients beyond age 60. Transplant Proc 25: 1075–1076
Epstein M (1979) Effect of aging on the kidney. Fed Proc 38: 168–172
Falkson G, Cnaan A, Schutt AJ et al. (1988) Prognostic factors for survival in hepatocellular carcinoma. Cancer Res 48: 7314
Fisher CH, Sheff RN, Novak G et al. (1974) The effect of superior mesenteric artery vasopressin infusion on cardiac output and coronary blood flow in dogs. J Invest Radiol 9: 456
Fitzgerald 0 (1972) Painless pancreatitis and other painless pancreatic disorders. Clin Gastroenterol 1: 195–218
Fujita S, Chiba M, Morimotoh-Satoh R, Kitani K, Suzuki T (1990) Possible mechanism for age-associated feminization of drug metabolizing ability of male rat liver. In: Kitani K (ed) Liver and aging. Elsevier, Amsterdam Oxford New York, pp 3–15
Ghadirian P, Simard A, Baillargeon J (1991) Tobacco, alcohol, and coffee and cancer of pancreas. Cancer 67: 2664–2670
Gibson PR, Dudley FJ (1984) Ischemic hepatitis: Clinical features, diagnosis and prognosis. Aust NZ J Med 14: 822
Gullo L, Priori P, Daniele C, Ventrucci M, Gasbarrini G, Labo G (1983) Exocrine pancreatic function in the elderly. Gerontology 29: 407–411
Gullo L, Ventrucci M, Naldoni P, Pezzilli R (1986) Aging and exocrine pancreatic function in the elderly. J Am Geriatr Soc 34: 790–792
Haddy TB, Castro OL, Rana SR (1988) Hereditary hemochromatosis in children, adolescent and young adults. Am J Pediatr Hematol Oncol 10: 23
Hale WE, Stewart RB, Marks RG (1983) Haematological and biochemical laboratory values in an ambulatory elderly population. An analysis of the effects of age, sex and drugs. Age Ageing 12: 275
Häussinger D, Maier KP (1996) Hepatische Enzephalopathie. Thieme, Stuttgart New York
Heinrich R, Schreckenberger A (1989) Normalbefunde am Gastrointestinaltrakt älterer Patienten. Z Geriatrie 2: 492–494
Hobson W, Jordon A (1959) A study of serum alkaline phosphatase levels in old people living at home. J Gerontol 14: 292
Holt PR (1986) Gastrointestinal drugs in the elderly. Am J Gastroenterol 81: 403
Imrie CW, Whyte AS (1975) A prospective study of acute pancreatitis. Br J Surg 62: 490–494
James OFW (1985) Drugs and the ageing liver. J Hepatol 1: 431
James OFW (1997) Parenchymal liver disease in the elderly. Gut 41: 430–432
Kampmann JP, Sinding J, Möller-Jorgensen I (1975) Effect of age on liver function. Geriatrics 30: 91
Kew M, Bersohn I, Seftel H et al. (1970) Liver damage in heatstroke. Am J Med 4: 192
Kitani K (1977) Aspects of the ageing liver. In: Platt D(ed). Liver and ageing, Schattauer Stuttgart New York 5.
Kuntz HD, Femfert B, May B (1986) Liver and ageing: Influence of age on liver function and drug metabolism. Dig Dis Sci 31: 195
Lai E (1992) Regulation of hepatic gene expression and development. Semin Liver Dis 12: 246–251
Lehman AB, Bassendine MF, James OFW (1985) Primary biliary cirrhosis: A different disease in the elderly? Gerontology 31: 2–14
Lemon SM, Shapiro CN (1994) The value of immunization against hepatitis A. Infect Agents Dis 3: 38–49
Meyers BR, Mendelsohn MH, Srulevitch-Chin E et al. (1987) Pharmacokinetic properties of mezlocillin in ambulatory elderly subjects. J Clin Pharmacol 27: 678–681
Müllers-Stein M, Lauter H (1988) Soziale Betreuung im höheren Lebensalter. In: Hippius H, Lauter H, Greil W (Hrsg) Psychiatrie für die Praxis. Bd. 8: Psychische Störungen im höheren Lebensalter. MMV, München, S 68–74
Nebert DW, Gonzales FJ (1985) Cytochrome P-450 gene expression and regulations. TIPS 165: 160–164
Niederau C, Fischer R, Sonnenberg A et al. (1985) Survival and causes of death in cirrhotic and non-cirrhotic patients with primary hemochromatosis. Engl J Med 313: 1256
Ochs HR, Verburg-Ochs B (1983) Einfluß von Alter, Gewicht, Geschlecht and Rauchgewohnheiten auf die Medikamentendosierung. Internist 24: 167
Offerhaus GJA, Tersmette AC, Tersmette KWF et al. (1988) Gastric, pancreatic and colorectal carcinogenesis following remote peptic ulcer surgery. Mod Pathol 1: 352–356
Park J, Fromkes J, Cooperman M (1986) Acute pancreatitis in elderly patients. Pathogenesis and outcome. Am J Surg 152: 638–642
Platt D (1995) Physiologische Alternsveränderungen and ihre Bedeutung für die Arzneimitteltherapie. Dtsch Ärztebl 34/35:C-1503–1506
Popper H (1985) Aging or withering of the liver? Hepatol Rapid Lit Rev 15: VII
Posner J, Danhof M, Teunissen MWE (1987) The disposition of antipyrine and its metabolites in young and elderly volunteers. Br J Clin Pharmacol 24: 51–55
Reidenberg MM, Levy M, Warner H et al. (1978) The relationship between diazepam dose, plasma level age and central nervous system depression in adults. Clin Pharmacol Ther 23: 371
Roll J, Boyer JL, Barry D et al. (1983) The prognostic importance of clinical and histological features in asymptomatic and symptomatic primary biliary cirrhosis. N Engl J Med 308: 1
Schalm SW, Weiland O, Hansen BE et al. (1999) Interferon-Ribaverin for chronic hepatitis C with and without Cirrhosis: Analysis of individual patient data of six controlled trials. Gastroenterology 117: 408–413
Schulz HJ, Schreiber L, Birke S et al. (1980) Untersuchungen zur Morphologie and Funktion des exkretorischen Pankreas im Alter. Dtsch Gesundheitswesen 35: 533–538
Siegel JH, Kasmin FE (1997) Biliary tract diseases in the elderly: Management and outcomes. Gut 41: 433–435
Strohmeyer G, Rodilla-Sala E, Häussinger D (1995) Leber and Gastrointestinaltrakt im Alter. Der Internist 7: 639–647
Trautwein C, Manns MP (1995) Erkrankungen der Leber im Alter. Internist 7: 668–676
Trautwein C, Kiral G, Tillmann HL, Witteler H, Michel G, Manns MP (1995) Risk factors and prevalence of hepatitis E in German immigrants from the former Soviet Union. J Med Virol 45: 429–434
Vestal RE, McGuire EA, Tobin JD et al. (1977) Aging and ethanol metabolism. Clin Pharmacol Ther 21: 343
Vestal RE, Wood AJ, Shand DG (1989) Reduced beta-adrenoceptor sensitivity in the elderly. Clinical Pharmacol Ther 26: 181
Wynne HA, Cope LH, Mutch E, Rawlins MD, Woodhouse KW, James OFEW (1989) The effect of aging upon liver volume and apparent liver blood flow in healthy man. Hepatology 9: 297–301
Wynne HA, Cope LH, Herd B, Rawlins MD, James OFW, Woodhouse KW (1990) The association of age and frailty with paracetamol conjugation in man. Age Ageing 19: 419–424
Literatur
Bjarnason I, Zanelli G, Smith T et al (1987) Non-steriodal anti-inflammatory drug induced intestinal inflammation in man. Gastroenterology 93: 480–489
Brynskov J, Freund L, Norby Rasmussen S, Lauritsen K, Schaffalitzky de Muckadell O, Williams CN, Macdonald AS, Tanton R, Molina F, Campanini MC, Bianchi P, Ranzi T, Quarto di Paulo F, Malcow-Moller A, Ostergaard Thomson O, Tage Jensen U, Binder V, Riffs P (1991) Final report of a placebo-controlled, double blind, randomized, multicentre trial of cyclosporin treatment in active chronic Crohn’s disease. Scand J Gastroenterol 26: 689–695
Caesar J, Schölmerich J (1995) Entzündliche Darmerkrankungen. Neue therapeutische Perspektiven. Klinikarzt 24: 28–39
Caspary WF, Arnold R, Bayerdörffer E, Behrens R, Birkner B, Braden B, Domschke W, Labenz J, Koletzko S, Malfertheiner P, Menge H, Rösch W, Schepp W, Strauch M, Stolte M (1996) Diagnostik and Therapie der Helicobacter-pylori-Infektion. DGVS-Leitlinien I. Z Gastroenterol 34: 392–401
Dajani AS, Bisno AL, Chung KJ, Durack DT, Freed M (1990) Prevention of bacterial endocarditis. Recommendations by the American Heart Assosiation. Clin Cardiol 12: 1919–1922
Daschner F (1998) Antibiotika am Krankenbett, 9. Aufl, Springer, Berlin Heidelberg New York Tokyo
Ekström P, Carling S, Wetterhus P, Wingren PE, Anker-Hansen 0, Lundgardh G, Thorhallsson E, Unge P(1996) Prevention of peptic ulcer and dyspeptic symptoms with omeprazole in patients receiving continuous non-steroidal anti-inflammatory drug therapy. Scand J Gastroenterol 31: 753–758
Ewe W, Weis HJ, Weihrauch TR (1992) Divertikulose, Divertikulitis. In: Wolff HP, Weihrauch TR (Hrsg) Internistische Therapie 1992/1993. Urban & Schwarzenberg, München Wien Baltimore, S 437–439
Feagan BG, Rocon J, Fedorak R, Irvine J, Wild G, Sutherland L, Steinhardt AH, Greenberg GR, Mc Donald J (1995) Methotrexate for the treatment of Crohn’s disease. N Engl J Med 332: 292–297
Gabriel SE, Jaakimainen L, Bombardier C (1991) Risk of serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. Ann Intern Med 115: 787–796
Greenbloom SL, Steinhart AH, Greenberg GR (1995) Ciprofloxacin and metronidazole: Combination antibiotic therapy of ileocolonic Crohn’s disease. Gastroenterology 108: A827
Greenwald DA, Brandt LJ (1998) Vascular abnormalities of the gastrointestinal tract. In: Feldman M, Scharschmidt BF, Sleisenger MH (eds), Sleisenger & Fordtran‘s Gastrointestinal and Liver Disease, vol 2, chap 119, 6. Saunders, Philadelphia London, edn. pp 2024–2034
Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA (1991) Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 114: 257–263
Henry D, Lim LLY, Rodriguez LAG, Perez Gutthann S, Carson JL, Griffin M, Savage R, Logan R, Moride Y, Hawkey C, Hill S, Fries JT (1996) Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis. BMJ 312: 1563–1566
Hochain P, Berkelmans I, Czernichow P, Duhamel C, Tranvouez JL, Lerebours E, Colin R (1995) Which patients taking non-aspirin non-steroidal anti-inflammatory drugs bleed? A case-control study. Eur J Gastroenterol Hepatol 7: 419–426
Holt PR (1995) Approach to gastrointestinal problems in the elderly. In: Yamada T (ed) Textbook of gastroenterology, 2nd edn, vol 2. Lippincott, Philadelphia, pp 968–988
Koch M, Dezi A, Ferrario F, Capurso L (1996) Prevention of nonsteroidal anti-inflammatory drug-induced gastrointestinal mucosal injury. A meta-analysis of randomized controlled clinical trials. Arch Intern Med 156: 2321–2321
Kohler B, Ginsbach C, Riemann JF (1989) Bacteriemia after laser therapy: In: Riemann JF, Ell C (Hrsg) Lasers in Gastroenterology. Thieme, Stuttgart New York, pp 147–150
Labenz J, Börsch, G (1996) Aktuelle Therapie der Helicobacter-pylori-Infektion. In: Malfertheiner P (eds.) Helicobacter pylori–Von der Grundlage zur Therapie, 2. Aufl. Thieme, Stuttgart, New York, S 149–163
Loeschke K, Ruckdeschel G (1992) Durchfälle unter Antibiotika. Diagnose and Therapie. Dtsch Ärztebl 89:B 221–224
Misiewicz G, Harris A (1995) Clinician‘s Manual on Helicobacter pylori. Science Press, London
Platt D (1995) Besonderheiten der Pharmakotherapie im Alter? Dtsch Ärztebl, 92: B1737–1741
Prantera C, Kohn A, Zannoni F, Spimpolo N, Bonfa M (1994) Metronidazole plus ciprofloxacin in the treatment of active, refractory Crohn‘s disease: results of an open study. J Clin Gastroenterol 19: 79–88
Sauter G, Ruckdeschel G, Sauerbruch T (1992) Antibiotische Prophylaxe and Therapie infektiöser Komplikationen. Z Gastroenterol 30: 705–709
Schölmerich J (1996) Therapie chronisch entzündlicher Darmerkrankungen. In: Klinik der Gegenwart, Bd 4, Kapitel 16. Urban & Schwarzenberg, München, S 1–44
Silverstein FE, Graham DY, Senior JR, Davies HW, Struthers BJ, Bittman RM, Geis GS (1995) Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. Ann Intern Med 123: 241–249
Singleton JW, Hanauer S, Gitnick GL, Peppercorn MA, Robinson M, Wruble L, Krawitt E (1993) Pentasa Crohn‘s Disease Study Group: Mesalamine capsules for the treatment of active Crohn‘s disease: results of a 16-week trial. Gastroenterology 104: 1293–1301
Taha AS, Hudson N, Hawkey CH, Swannell AJ, Trye PN, Cottrell J, Mann SG, Simon TJ, Sturrock RD, Russell RI (1996) Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med 334: 1435–1439
Weber JR, Ryan JC (1998) Effects on the gut of systemic disease and other extraintestinal conditions. In: Feldman M, Scharschmidt BF, Sleisenger MH (eds), Sleisenger & Fordtran‘s Gastrointestinal and Liver Disease, vol 1, chap 29, 6. edn. Saunders, Philadelphia London pp 429–438
Westergaard, H. (1998) Short Bowel Syndrome. In: Feldman M, Scharschmidt BF, Sleisenger MH (eds), Sleisenger & Fordtran’s Gastrointestinal and Liver Disease, vol 2, chap 91, 6. edn. Saunders, Philadelphia London pp 1548–1556
Klotz U, Avant GR, Hoyumpa A, Schenker S, Wilkinson GR (1975) The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Investig 55: 347–359.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Strohmeyer, G., Spamer, C. (2000). Leber-Magen-Darm-Erkrankungen. In: von Bruchhausen, F., Lemmer, B. (eds) Arzneimitteltherapie für ältere Menschen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59590-5_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-59590-5_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-64851-2
Online ISBN: 978-3-642-59590-5
eBook Packages: Springer Book Archive