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Schlaganfallbehandlung — medikamentöse Behandlung des Schlaganfalls

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Zusammenfassung

Der akute Schlaganfall stellt eine Notfallsituation dar, die eine unverzügliche Diagnostik und Therapieeinleitung erforderlich macht. Wenn es auch heute eine allgemeingültige, durch kontrollierte Studien gesicherte Therapie des Schlaganfalls nicht gibt, finden sich dennoch zahlreiche vielversprechende Therapieansätze.

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Literatur

  1. Adams HP, Brott TG, Furlan AJ, et.al. (1996) Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke. Circulation 94:1167–1174

    PubMed  Google Scholar 

  2. Aichner FT, Fazekas F, Brainin M, Pölz W, Mamoli B, Zeiler K (1998) Hypervolemic hemodilution in acute ischemic stroke. The Multicenter Austrian Hemodilution Stroke Trial (MAHST) Stroke 29:743–749

    PubMed  CAS  Google Scholar 

  3. Ancrod Stroke Study Investigators (1994) Ancrod for the treatment of acute ischemic brain infarction. Stroke 25:1755–1759

    Article  Google Scholar 

  4. Asplund K (1991) Hemodilution in acute stroke. Cerebrovasc Dis 1 [Suppl] 129–138

    Article  Google Scholar 

  5. Chinese Acute Stroke Trial Collaborative Group (1997) CAST: randomised placebo-controlled trial of early aspirin use in 20000 patients with acute ischemic stroke. Lancet 349:1641–1649

    Article  Google Scholar 

  6. Connolly SJ, Laupacis A, Gent M, Roberts RS, Cairns JA, Joyner C (1991) Canadian Atrial Fibrillation Anticoagulaton (CAFA) Study. J Am Coll Cardiol 18:349–355

    Article  PubMed  CAS  Google Scholar 

  7. Davies SM, Albers GW, Diener HC Lees KR, Norris J (1997) (ASSIST Steering Committee) Termination of acute stroke studies involving selfotel treatment. Lancet 349:32

    Article  Google Scholar 

  8. DeDeyn PP, Reuck JD, Deberdt W, Vlietinck R, Orgogozo JM (1997) Treatment of acute ischemic stroke with piracetam. Members of the Piracetam in Acute Stroke Study (PASS) Group. Stroke 28(12):2347–2352

    Article  CAS  Google Scholar 

  9. Diener HC, Hacke W, Hennerici M, Rädberg J, Hantson L, De Keyser J (1996) Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Stroke 27:76–81

    Article  PubMed  CAS  Google Scholar 

  10. Diener HC, Kaste M, Hacke W et al. (1997) Lubeluzole in acute ischemic stroke. Stroke 28:271

    Google Scholar 

  11. Diener HC, Cunha L, Forbes C, Silvenius J, Smets P, Lowenthal A (1996) European Stroke Prevention Study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurologi Sci 143:1–13

    Article  CAS  Google Scholar 

  12. Donnan GA, Davis SM, Chambers BR, et al. for the Australian Streptokinase (ASK) Trial Study Group (1996) Streptokinase for acute ischemic stroke with relationship to time of administration. JAMA 276:961–966

    Article  Google Scholar 

  13. EAFT (European Atrial Fibrillation Trial) Study Group (1993) Secondary Prevention in non-rheumatic atrial fibrillation after tansient ischemic attack or minor stroke. Lancet 342:1255–1262

    Google Scholar 

  14. Fisher M, Bogousslaysky J (1998) Further evolution toward effective therapy for acute ischemic stroke. JAMA 279:1298–1303

    Article  PubMed  CAS  Google Scholar 

  15. Franke CL, Palm R, Dalby M, Schoonderwaldt HC, Hantson L, Eriksson B, Lang- Jenssen L, Smakman J (1996) Flunarizine in stroke treatment (FIST): a double-blind, placebo-controlled trial in Scandinavia and the Netherlands. Acta Neurol Scand 93:56–60

    Article  PubMed  CAS  Google Scholar 

  16. Füsgen I (1995) Schlaganfall. MMV Medizin Verlag, München

    Google Scholar 

  17. Gelmers H et al. (1990) Effect of nimodipine on acute ischemic stroke. Stroke 21 [Suppl 4]: 81–84

    Google Scholar 

  18. Giroux Ch, Scatton B (1996) Ischemic stroke: Treatment on the horizon. Eur Neurol 36:61–64

    Article  PubMed  CAS  Google Scholar 

  19. Goslinga H, Eijzenbach V, Heuvelmanns JH, van der Laan E, Melis VM, Schmid-Schönbein H, Bezemer PD (1992) Custom-tailored hemodilution with albumin and crystal­loids in acute ischemic stroke. Stroke 23:181–188

    Article  PubMed  CAS  Google Scholar 

  20. Hacke W, Kaste M, Fieschi C, et al for Acute Stroke Study (ECASS) Group (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. JAMA 274:1017–1025

    Article  Google Scholar 

  21. Helgason CM (1988) Blood glucose and stroke. Stroke 19;1049–1053

    Article  PubMed  CAS  Google Scholar 

  22. Hommel L, Boissel JP, Cornu C, et al. (1995) Termination of trial of streptokinase in severe acute ischemic stroke. Lancet 345:57

    Article  PubMed  CAS  Google Scholar 

  23. Huber M. (1992) Akuttherapie des Hirninfarkts. Intensivmed 29:427–434

    Google Scholar 

  24. Huber M, Heiss WD (1996) Acute ischemic stroke. Seminars in thrombosis and hemostasis 22:53–60

    Article  PubMed  CAS  Google Scholar 

  25. Jonas S (1988) Anticoagulant therapy in cerebrovascular disease: review and meta-analysis. Stroke 19:1043–1048

    Article  PubMed  CAS  Google Scholar 

  26. Kay R et al. (1995) Low-molecular-weight heparin for the treatment of acute ischemic stroke. New Engl J Med 333:1588–1593

    Article  PubMed  CAS  Google Scholar 

  27. Marx P, Haas A, Hartmann A (1995) Hämodilutionsbehandlung des ischämischen Insults. MMW 137:147–150

    Google Scholar 

  28. Multicenter Acute Stroke Trial - Italy (MAST-I) Group (1995) Randomised controlled trial of streptokinase, aspirin and combination of both in treatment of acute ischemic stroke. Lancet 346:1509–1524

    Google Scholar 

  29. Matchar DB, McCrory DC, Barnett HJM, Feussner JR (1994) Medical treatment for stroke prevention. Ann Intern Med 121:41–53

    PubMed  CAS  Google Scholar 

  30. Mohr JP, Orgogozo JM, Harrison MJG et al. (1994) Meta-analysis of oral nimodipine trials in acute stroke. Cerebrovasc Dis 4:197–203

    Article  Google Scholar 

  31. Mullay GP (1992) Stroke. In: Brocklehurst JC, Tallis RC, Fillit HM (eds) Textbook of Geriatric Medicine and Gerontology. Churchill Livingstone, Edinburgh

    Google Scholar 

  32. Norton B, Homer-Ward M, Donelly MT, Long RG, Holmes GKT (1996) A randomised prospective comparison of percutaneous endoscopic gastrostomy and nasogastric tube feeding after acute dysphagic stroke. BMJ 312:13–16

    Article  PubMed  CAS  Google Scholar 

  33. Norris JW (1976) Steroid therapy in acute cerebral infarction. Arch Neurol 33:69–71

    Article  PubMed  CAS  Google Scholar 

  34. Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B (1989) Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study. Lancet 1:175–179

    Article  PubMed  CAS  Google Scholar 

  35. Platt D, Horn J, Summa JD (1992) Zur Wirksamkeit von Piracetam bei geriatrischen Patienten mit akuter zerebraler Ischämie. Med Welt 181–190

    Google Scholar 

  36. Pulsinelli WA, Levy DE, Sigsbee B (1982) Increased damage after stroke in patients with hyperglycemia with or without established diabetes mellitus. Am J Med 540–544

    Google Scholar 

  37. Quality Standard Subcommittee of the American Academy of Neurology (AAN) (1996) Thrombolytic therapy for acute ischemic stroke: summary statement. Neurology 47:835–839

    Google Scholar 

  38. Reith J, Jorgensen HS, Pedersen PM, Nakamaya H, Raaschou HO, Jeppesen LL, Olsen TS (1996) Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 347:422–425

    Article  PubMed  CAS  Google Scholar 

  39. Sandercock P et al. (1993) Medical treatment of acute ischemic stroke. Lancet 339:537–539

    Article  Google Scholar 

  40. Strand T (1992) Evaluation of long-term outcome and safety after hemodilution therapy in acute ischemic stroke. Stroke 23:657–662

    Article  PubMed  CAS  Google Scholar 

  41. Stroke Prevention in Atrial Fibrillation Investigators (1991) Stroke Prevention in Atrial Fibrillation Study. Final results. Circulation 84:527–539

    Google Scholar 

  42. The American Nimodipine Study Group (1992) Clinical trial of nimodipine in acute ischemic stroke. Stroke 23:3–8

    Article  Google Scholar 

  43. The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. The effect of low-dose warfarin on the risk of stroke in patients with non-rheumatic atrial fibrillation. N Engl J Med. 327:1406–1412

    Google Scholar 

  44. The International Stroke Trial Collaborative Group (1997) The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischemic stroke. Lancet 349:1569–1581

    Article  Google Scholar 

  45. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587

    Article  Google Scholar 

  46. The Publications Committee for the trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators (1998) Low molecular weight heparinoid, ORG 10172(Danaparoid), and outcome after acute ischemic stroke. JAMA 279:1265–1272

    Article  Google Scholar 

  47. The US and Canadian Lubeluzole Ischemic Stroke Study Group (1997) Lubeluzole treatment of acute ischemic stroke. Stroke 28:2338–2346

    Article  Google Scholar 

  48. Wahlgren NG, and the Clomethiazole Acute Stroke Study Collaborative Group (1997) The Clomethiazole Acute Stroke Study (CLASS), abstract. Cerebrovasc Dis 7 [Suppl. 4]:19

    Google Scholar 

  49. Werner HJ (1995) Fieber. In: Füsgen I (Hrsg) Der ältere Patient. Urban & Schwarzenberg, München New York

    Google Scholar 

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Harlacher, R., Füsgen, I. (2000). Schlaganfallbehandlung — medikamentöse Behandlung des Schlaganfalls. In: von Bruchhausen, F., Lemmer, B. (eds) Arzneimitteltherapie für ältere Menschen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59590-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-59590-5_3

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  • Print ISBN: 978-3-540-64851-2

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