Genes and Centenarians

  • T. Perls
  • R. Fretts
  • M. Daly
  • S. Brewster
  • L. Kunkel
  • A. Puca
Conference paper
Part of the Research and Perspectives in Longevity book series (RPL)


It has been purported that aging was due to the interaction of many genes, perhaps eight to ten thousand, with weak effects interacting with one another and our internal and external environments. Yet genetic experiments in lower organisms and our own centenarian pedigree data indicate that at least a few genes may exist that exert a powerful influence upon longevity. Experiments C. elegans, Drosophila and yeast show that the manipulation of one or a few different genes can result in the doubling to quintupling of life span. We have found that a sibling of a centenarian has a four to five times greater chance of reaching his/her early nineties compared to the sibling of someone who died his/her early 70s (Hitt 1999).


Premature Ovarian Failure Average Life Expectancy Human Longevity Pilot Whale Human Life Span 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • T. Perls
  • R. Fretts
  • M. Daly
  • S. Brewster
  • L. Kunkel
  • A. Puca

There are no affiliations available

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