Abstract
Forensic medicine and neuropathology not infrequently come together in the investigation of cases of sudden death, which in a small but significant number of instances is due to intracranial pathology rather than cardiovascular disease. Clinical information may help to provide the cause of an unexpected death but may be absent in circumstances that are unexplained.
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References
Adams JH (1992) Head injury. In: Adams JH, Duchen LW (eds) Greenfield’s neuropathology, 5th edn. Edward Arnold, London, pp 106–152
Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR (1989) Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology 15:49–59
Adams JH, Doyle D, Graham DI, Lawrence AE, McLellan DR (1984) Diffuse axonal injury in head injuries caused by a fall. Lancet 2:1420–1421
Adams JH, Graham DI (1976) The relationship between ventricular fluid pressure and the neuropathology of raised intracranial pressure. Neuropathol Appl Neurobiol 2:323–332
Adams JH, Graham DI, Murray LS, Scott G (1982) Diffuse axonal injury due to non-missile head injury in humans: an analysis of 45 cases. Ann. Neurology 12:557–563
Annegers JF, Hauser WA, Shirts SB (1984) Heart disease mortality and morbidity in patients with epilepsy. Epilepsia 25(6):699–704
Blumbergs PC, Jones NR, North JB (1989) Diffuse axonal injury in head trauma. J Neurol Neurosurg Psychiat. 52:838–841
Bromilow A, Burns J (1985) Technique for removal of the vertebral arteries. J Clin Pathol 38:1400–02
Brown SW, Mawar GE, Lawler W, Taylor DC, Shorvon S, Betts TA, Noronha MJ et al. (1990) Sudden death and epilepsy. Lancet (letters) 335:606–607
Cameron JM, Mant AK (1972) Fatal subarachnoid haemorrhage associated with cervical trauma. Med Sci Law 12:66–70
Coast GC, McGhee DJ (1984) Traumatic subarachnoid haemorrhage: an alternative source. J Clin Pathol 37:1245–1248
Contostavlos DL (1971) Massive subarachnoid haemorrhage due to laceration of the vertebral artery associated with fracture of the transverse process of the atlas. J Forensic Sci 16:40–56
Contostavlos DL (1995) Isolated basilar subarachnoid haemorrhage: an observer’s 25 year re-evaluation of the pathogenic possibilities. Forensic Sci Int 73:61–74
Cordobes F, de la Fuente M, Lobato RD, Roger R, Perez C, Millan JM, Bargena A et al. (1983) Intraventricular haemorrhage in severe head injury. J Neurosurgery 58:217–222
Crawford MD, Sarner M (1965) Ruptured intracranial aneurysms: community study. Lancet ii 1254–1257
Deck JH, Jagadha V (1986) Fatal subarachnoid haemorrhage due to traumatic rupture of the vertebral artery. Arch Pathol Lab Med 110:489–493
DiMaio S J, Dimaio VJM, Kirkpatrick J (1980) Sudden death due to primary intracranial neoplasm. Am J Forensic Med Pathol 1:29–46
Dinning TAR, Falconer MA (1953) Sudden or unexpected natural death due to ruptured intracranial aneurysms: survey of 250 forensic cases. Lancet 2:799–801
Dowling G, Currie B (1988) Traumatic basal subarachnoid haemorrhage. Amer J Forensic Med Pathol 9:23–31
Drake CG (1979) The treatment of aneurysms of the posterior circulation. Clin Neurosurg 26:96–144
Ficker DM, So EL, Shen WK, Annegers JF, O’Brien PC, Cascino GD, Belau PG (1998) Population-based study of the incidence of sudden unexplained death in epilepsy. Neurology 51:1270–1274
Freytag E (1966) Fatal rupture of intracranial aneurysms. Arch Pathol 81:418–424
Freytag E (1968) Fatal hypertensive intracerebral haematomas. J Neurol Neurosurg Psychiat 31:616–620
Freytag E, Lindenberg R (1964) 294 medicolegal autopsies on epileptics. Arch Pathol 78:274–286
Gee DJ (1982) Traumatic subarachnoid haemorrhage. Proceedings of the 12th Congress of the International Academy of Forensic and Social Medicine. Egermann, Vienna, pp 495–498
Gennarelli TA (1983) Head injury in man and experimental animals — clinical aspects. Acta Neurochirug Suppl 32:1–3
Graham DI, Lawrence AE, Adams JH, Doyle D, McLellan DR (1987) Brain damage in nonmissile head injury secondary to a high intracranial pressure. Neuropathol Appl Neurobiol 13:209–217
Grcevic N (1983) Traumatic tears to the tela choriodia: a hitherto unrecognised cause of post-traumatic hydrocephalus. Acta Neurochirug Suppl. 32:79–85
Hanna J (1997) Epilepsy and sudden death: a personal view. Epilepsia 38[suppl 11]:S3–S5
Harland WA, Pitts JF, Watson AA (1983) Subarachnoid haemorrhage due to upper cervical trauma. J Clin Pathol 36:1335–1341
Hirsch CS, Martin DL (1971) Unexpected death in young epileptics. Neurology 21:682–689
Johnson CP, Scraggs M, How T, Burns J (1995) A necropsy and histomorphometric study of abnormalities in the course of the vertebral artery associated with ossified syloinoid ligaments. J Clin Pathol 48:637–640
Johnston SC, Horn JK, Valente J, Simon RP (1995) The role of hypoventilation in a sheep model of epileptic sudden death. Ann Neurol 37:531–537
Kassell NF, Torner JC, Haley EC, Jane JA, Adams HP, Kongable GL (1990) The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results. J Neurosurg 73:18–36
Kenneback G, Ericson M, Tomson J, Bergfeldt L (1997) Changes in arrhythmia profile and heart rate variability during abrupt withdrawal of anti-epileptic drugs. Implications for sudden death. Seizure 6:369–375
Kloster R, Engelskjon T (1999) Sudden unexpected death in epilepsy (SUDEP): a clinical perspective and a search for risk factors. J Neurol Neurosurg Psychiatry 67:439–444
Knight B (1996) Forensic pathology, 2nd edn. Edward Arnold, London
KrohnW (1963) Causes of death among epileptics. Epilepsia 4:315–321
Laposata EA, Hale P, Poklis A (1988) Evaluation of sudden death in psychiatric patients with special reference to phenothiazine therapy: forensic pathology. J Forensic Sci 33:432–440
Leadbetter S (1994) Extracranial vertebral artery injury — evolution of a pathological illusion? Forensic Sci Int 67:33–40
Leestma JE, Teas SS, Hughes JR, Kalelkar MB (1985) Sudden epilepsy deaths and the forensic pathologist. Am J Forensic Med Pathol 6(3):215–218
Leestma JE, Walczak T, Hughes JR, Kalelkar MB, Teas SS (1989) A prospective study on sudden unexpected death in epilepsy. Ann Neurol 26:195–203
Lhatoo SD, Langan Y, Sander JWAS (1999) Sudden and unexpected death in epilepsy. Postgrad Med J 75:706–709
Lindenberg R (1971) Trauma of meninges and brain. In: Minckler J (ed) Pathology of the nervous system, vol 2. McGraw Hill, New York, pp 1705–1765
Lindenberg R, Freytag E (1970) Brainstem lesions characteristic of traumatic hyperextension of the head. Arch Pathol 90:509–515
Lip GYM, Brodie MJ (1992) Sudden death in epilepsy: an avoidable outcome. J R Gy Soc Med 1992 85:609–611
Little JR, Dial B, Belanger G, Carpenter S (1979) Brain haemorrhage from intracranial tumour. Stroke 10:283–288
Ljunggren B, Saveland H, Brandt L, Zygmunt S (1985) Early operation and overall outcome in aneurysmal subarachnoid haemorrhage. J Neurosurg 62:547–551
Mandybur TI (1977) Intracranial haemorrhage caused by metastatic tumours. Neurology 27:650–655
Mason JK (1995) Forensic medicine for lawyers, 3rd edn. Butterworths, London, Dublin, Edinburgh
Maxwell WL, Hardy IG, Watt C, McGadey J, Graham DI, Adams JH, Gennarelli TA (1992) Changes in the choroid plexus, responses by intrinsic epiplexus cells and recruitment from monocytes after experimental head acceleration injury in the non-human primate. Acta Neuropathol 84:78–84
Maxwell WL, Whitfield PC, Suzen B, Graham DI, Adams JH, Watt C, Gennarelli TA (1992) The cerebrovascular response to experimental lateral head acceleration. Acta Neuropathol 84:289–296
Miller JD, Ironside JW (1997) Raised intracranial pressure, oedema and hydrocephalus. In: Graham DI, Lantos PL (eds) Greenfield’s neuropathology, 6th edn. Arnold, London, pp 157–195
Nashef L (1997) Sudden unexpected death in epilepsy: terminology and definitions. Epilepsia 38[suppl 11]:S6–S8
Nashef L, Walker F, Allen P, Sander JWAS, Shorvon SD, Fish DR (1996) Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy. J Neurol Neurosurg Psychiatry 60:297–300
Nilsson L, Farahmand BY, Persson P-G, Thibilin I, Tomson T (1999) Risk factors for sudden unexpected death in epilepsy: a case-control study. Lancet 353:888–893
Nishioka H (1966) Report on the co-operative study of intracranial aneurysms and subarachnoid haemorrhage. Section VII, Part 1: Evaluation of the conservative management of ruptured intracranial aneurysms. J Neurosurg 25:574–592
O’Donoghue MF, Sander JW (1997) The mortality associated with epilepsy, with particular reference to sudden unexpected death: a review. Epilepsia 38[suppl 11]:S15–S19
Opeskin K, Anderson RM, Lee KA (1993) Colloid cyst of the third ventricle as a cause of acute neurological deterioration and sudden death. J Paediat Child Health 29:476–477
Peerless SJ, Drake CC (1990) Management of aneurysm of the posterior circulation. In: Youmans JR (ed) Neurosurgical surgery: a comprehensive reference guide to the management of aneurysmal problems, 3rd edn, vol 3. WB Saunders, Philadelphia, pp 1764–1800
Peerless S J, Rewcastle NB (1967) Shear injuries of the brain. Canad Med Assoc 96:577–582
Phillips LH, Whisnant JP, O’Fallon WM, Sundt TM (1980) The unchanging pattern of subarachnoid haemorrhage in a community. Neurology 30:1034–1040
Rasmussen P. Bosch H, Haase J et al. (1980) Intracranial saccular aneurysms: results of treatment in 851 patients. Acta Neurochirur 53:1–17
Schievink WI, Van Der Werf DJM, Hageman LM, Dreissen JJ (1988) Referral pattern of patients with aneurysmal subarachnoid hemorrhage. Surg Neurol 29:367–371
Schievink WI, Wijdicks EFM, Piepgras DG, Chu C-P, O’Fallon M, Whisnant JP (1995) The poor prognosis of ruptured intracranial aneurysms of the posterior circulation. J Neurosurg 82:791–795
Schwender LA, Troncoso JC (1986) Evaluation of sudden death in epilepsy. AM J Forensic Med Pathol 7(4):283–287
Sillanpau ML, Koskenvuo MJ (1994) Population-based mortality of persons with epilepsy. Epilepsia 35(7):18
Simpson K (1947) Pathology of sudden death. Lancet: 745–747
Strich S J (1961) Shearing of nerve fibres as a cause of brain damage due to head injury. Lancet 2:443–448
Strich SJ (1976) Cerebral trauma. In: Blackwood W, Corsellis JA (eds) Greenfield’s neuropathology. 3rd edition. Edward Arnold, London, pp 327–360
Sundt TM, Kobayashi S, Fode NC, Whisnant JP (1982) Results and complications of surgical management of 809 intracranial aneurysms in 722 cases. J Neurosurg 56:753–765
Tatsuno Y, Lindenberg R (1974) Basal subarachnoid haematomas as sole intracranial traumatic lesions. Arch Pathol 97:211–215
Tennis P, Cole TB, Annegers JF, Leestma JE, McNutt M, Rajput A (1995) Cohort study of incidence of sudden unexplained death in persons with seizure disorder treated with anti-epileptic drugs in Saskatchewan, Canada. Epilepsia 36 (1):29–36
Terrence CF, Wisotzskey HM, Perper JA (1975) Unexpected, unexplained death in epileptic patients. Neurology 25:594–598
Thorn M (1997) Neuropathologic findings in post-mortem studies of sudden death in epilepsy. Epilepsia 38 [suppl 11]:532–534
Tomlinson BE (1970) Brain-stem lesions after head injury. J Clin Pathol 23: Suppls (R Coll Pathol) 4:154–165
Troupp H (1971) The natural history of aneurysms of the basilar bifurcation. Acta Neurol Sciences 47:350–356
Vanezis P (1984) Vertebral artery trauma: a post-mortem study. MD Thesis, University of Bristol
Vanezis P (1989) Pathology of neck injury. Butterworths, London
VanParijs JAP, deHaan GJ, Mantel R, Meüer P (1994) Mortality in the outpatient population of a Dutch epilepsy centre. Epilepsia 35 [suppl 7]:18
Walker F, Fish DR (1997) Recording respiratory parameters in patients with epilepsy. Epilepsia 39(11):S31–S42
Wiebers DO, Whisnant JP, O’Fallon WM (1981) The natural history of unruptured intracranial aneurysms. N Engl J Med 304:696–698
Wilberger JE, Ruthfus WE, Tabas J, Goldbere AL, Deeb ZI (1990) Acute tissue tear haemorrhages of the brain: computed tomography and clinicopathological correlations. Neurosurgery 27:208–213
Wilkinson IM (1972) The vertebral artery. Extracranial and intracranial structure. Arch Neurol 27:392–396
Zielinski JJ (1974) Epilepsy and mortality rate and cause of death. Epilepsia 15:191–201
Zimmerman RA, Larissa T, Gilaniuk LT, Gennarelli TA (1978) Computed tomography of shearing injuries of the cerebral white matter. Radiology 127:393–396
Zuccarello M, Iavicoli R, Pardatscher K, Cervellini P, Fiore D, Minerino S, Gerosa M (1981) Post-traumatic intraventricular haemorrhages. Acta Neurochir 55:283–293
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Black, M., Graham, D.I. (2001). Sudden Unexplained Death in Adults. In: Love, S. (eds) Neuropathology. Current Topics in Pathology, vol 95. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59554-7_4
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DOI: https://doi.org/10.1007/978-3-642-59554-7_4
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