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Insensitive Acetylcholinesterase as Sites for Resistance to Organophosphates and Carbamates in Insects: Insensitive Acetylcholinesterase Confers Resistance in Lepidoptera

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Biochemical Sites of Insecticide Action and Resistance

Abstract

Acetylcholinesterase (EC 3.1.1.7) is the enzyme responsible for hydrolysing the neurotransmitter acetylcholine at the nerve synapse. If this hydrolysis does not take place, build-up of acetylcholine occurs leading to repeated firing of neurones and ultimately death by exhaustion. Vertebrate species possess acetylcholinesterase and butyrylcholinesterase (EC 3.1.1.8), differentiated by substrate preferences, whilst arthropods have only one enzyme which, whilst containing characteristics of both, is generally considered to be AChE (Toutant 1989).

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Author information

Authors and Affiliations

  1. NSW Agriculture, Tamworth Centre for Crop Improvement, RMB 944 Calala Lane, Tamworth, NSW, Australia, 2340

    Robin V. Gunning

  2. Department of Biological and Ecological Chemistry, IACR-Rothamsted, AL5 2JQ, Harpenden, Herts, UK

    Graham D. Moores

Authors
  1. Robin V. Gunning
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  2. Graham D. Moores
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Editors and Affiliations

  1. Department of Entomology Agricultural Research Organization, The Volcani Center, Bet Dagan, 50250, Isarael

    Isaac Ishaaya

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Gunning, R.V., Moores, G.D. (2001). Insensitive Acetylcholinesterase as Sites for Resistance to Organophosphates and Carbamates in Insects: Insensitive Acetylcholinesterase Confers Resistance in Lepidoptera. In: Ishaaya, I. (eds) Biochemical Sites of Insecticide Action and Resistance. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59549-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-59549-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67625-6

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