Childhood Brucellosis

  • M. Monir Madkour


Childhood brucellosis is a common disease in endemic areas, while it is rarely reported in non-endemic areas. Its clinical features are protean and simulate those of other febrile illnesses. Children are more prone to many different viral illnesses, and many children with active brucellosis in endemic areas are initially misdiagnosed and treated for other infectious diseases. In its milder form of presentation, particularly when physical signs are lacking, the disease many be initially dismissed as psychological.


Splenic Abscess Subdural Empyema Brucella Abortus Brucella Melitensis Animal Contact 
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  1. Abd Elrazak, M. (1991) Brucella optic neuritis. Arch Intern Med (United States), 151, 776–778Google Scholar
  2. Abramsky, O. (1977) Neurological features as presenting manifestations of brucellosis. Eur. Neurol, 15, 281–285PubMedGoogle Scholar
  3. Adam, A., MacDonald, A., and MacKenzie, I.G. (1974) Monoarticular brucellar arthritis in children. J Bone Joint Surg., 56, 217Google Scholar
  4. Al Dubooni, H.M., Al Shirkat, S.A., Nagi, N.A. (1986) Brucellosis in children in Iraq. Ann Trop Paediatr, 6, 271–274Google Scholar
  5. Al Eissa, Y.A. (1995) Clinical and therapeutic features of childhood neurobrucellosis. Scand Infect Dis, 27, 339–343Google Scholar
  6. Al Eissa, Y.A. (1990) Probable breast-milk borne brucellosis in a young infant. Ann Trop Paediatr (England), 10, 305–307Google Scholar
  7. Al Eissa, Y.A. (1993) Unusual suppurative complications of brucellosis in children. Acta Paediatr, 82, 987–992Google Scholar
  8. Al Eissa, Y.A., Al Herbish, A.S. (1996) Severe hypertension: an unusual presentation of Guillain-Barre syndrome in a child with brucellosis. Eur J Pediatr, 155, 53–55Google Scholar
  9. Al Eissa, Y.A., Al Mofada, S.M. (1992) Congenital brucellosis. Pediatr Infect Dis J (United States), 11, 667–671Google Scholar
  10. Al Eissa, Y., Al Nasser, M. (1993) Haematological manifestations of childhood brucellosis. Infection, 21, 23–26Google Scholar
  11. Al Eissa, Y., Al Zamil, F., Al Mugeiren, M., Al Rasheed, S., Al Sanie, A., Al Mazyad, A. (1991) Childhood brucellosis: a deceptive infectious disease. Scand J Infect Dis (Sweden), 23, 129–133Google Scholar
  12. Al-Eissa, Y.A., Al-Zamil, F.A., Al-Nasser, M.N. (1994) Duration of Chemotherapy for childhood brucellosis. Pediatr Infect Dis J, 13, 335–336PubMedGoogle Scholar
  13. Al Eissa, Y.A., Assuhaimi, S.A., Al Fawaz, I.M., Higgy, K.E., Al Nasser, M.N., Al Mobaireek, K.F. (1993) Pancytopenia in children with brucellosis: clinical manifestations and bone marrow findings. Acta Haematol, 89, 132–136Google Scholar
  14. Al Eissa, Y.A., Kambal, A.M., Al Rabeeah A.A., Abdullah A.M., Al-Jurayyan, N.A., Al Jishi, N.M. (1990) Osteoarticular brucellosis in children. Ann Rheum Dis (England), 49, 896–900Google Scholar
  15. Al Eissa, Y.A., Kambal, A.M., Al Nasser, M.N., Al Habib, S.A., Al Fawaz, I.M., Al-Freihi, M., Al Mohaya, S.A. et al (1986) Brucellosis in Saudi Arabia: Diverse manifestation of an important cause of pyrexial illness. Annals of Saudi Medice, 6, 95Google Scholar
  16. Al Mafada, S.M., Al Eissa, Y.A., Saeed, E.S., Kambal, A.M. (1993) Isolation of Brucella melitensis from human milk. J Infect, 26, 346–348Google Scholar
  17. Al Zamil, F.A. (1990) Childhood brucellosis: a study of 102 cases. Pediatr Infect Dis J, 9, 74–79Google Scholar
  18. Alvarez de Buergo, M., Gomez Reino, F.J., Gomez Reino, J.J. (1990) A long term study of 22 children with brucellar arthritis. Clin Exp Rheumatol (Italy), 8, 609–612Google Scholar
  19. Ayala-Gaytan, J.J., Ortegon-Baqueiro, H., de la Maza, M. (1989) Brucella melitensis cerebellar abscess. J Infect Dis, 160, 730–732PubMedGoogle Scholar
  20. Barroso, E.D., Arroyo, C.I., et al (1998) The transmission of brucellosis via breastfeeding. A report of 2 cases. An Esp. Pediatr (Spain), 48, 60–62.Google Scholar
  21. Benjamin, B. (1995) Acute thrombocytopenic purpura in child-hood brucellosis. Ann Tro Pediatric, 15, 189–192Google Scholar
  22. Benjamin, B., Annobil, S.H., Khan, M.R. (1992) Osteoarticular complications of childhood brucellosis: a study of 57 cases in Saudi Arabia. J Pediatr Orthop (United States), 12, 801–805Google Scholar
  23. Benjamin, B., Khan, M.R. (1994) Hip involvement in childhood brucellosis. J Bone Joint Surg Br, 76, 544–547PubMedGoogle Scholar
  24. Benjamin, B., Annobil, S.H. (1992) Childhood brucellosis in southwestern Saudi Arabia: a 5-year experience. J Trop Pediatr (England), 38, 167–172Google Scholar
  25. Bishop, W.A. (1939) Vertebral lesions in undulant fever. J Bone Surg., 21, 665–673Google Scholar
  26. Black, R.A. (1937) Brucella melitensis meningitis in an infant. Arch. Pediatr., 54, 702–713Google Scholar
  27. Bocanegra, T.S. et al (1986) Rheumatic manifestation of brucellosis. Ann. Rheum. Dis., 45, 526PubMedGoogle Scholar
  28. Bothwell, P.W. (1962) Brucellosis in children. Arch. Dis. Child., 37, 628–639PubMedGoogle Scholar
  29. Buchanan, T.M., Faber, L.V. and Feldman, R.A. (1974) Brucellosis in the United States 1960–1972: an abattoir-associated disease. Part I. Clinical features and therapy. Medicine, 53, 403–413PubMedGoogle Scholar
  30. Buchanan, T.M., Sulzer, C.R., Frix, M.K. and Feldman, R.A. ( 1947 A) Brucellosis in the United States 1960–1972: an abattoir-associated disease. Part II. Diagnostic aspects. Medicine, 53, 415–425Google Scholar
  31. Buchanan, T.M., Hendricks, S.L., Patton, C.M. AND Feldman, R.A. (1974B) Brucellosis in the United States, 1960–1972: an abattoir-associated disease. Part III. Epidemiological and evidence of immunity. Medicine, 53, 427–439Google Scholar
  32. Casalinuovo, F., Di-Sarno, A., Caparello, G., Saladino, A. (1995) Isolation of Brucella melitensis biovar 2 from the human milk. Ann Ig, 7, 91–95PubMedGoogle Scholar
  33. Cataldo, F., Scotto, E. and De Gregorio, T. (1983) Brucellosis in a five month old infant infected by mother. Acta Mediterranea Patol. Infett. Tropic., 2, 29–33Google Scholar
  34. Chheda, S., Lopez S.M., Sanderson E.P. (1997) Congenital Brucellosis in a premature infant. Pediatr Infect Dis J, 16, 81–83PubMedGoogle Scholar
  35. Chowdhary, U.M., Twum-Danso, K. (1991) Brucella meningoencephalitis associated with cerebrospinal fluid shunt in a child: case report. Surg Neurol, 35, 468–470PubMedGoogle Scholar
  36. Coll, M.D., Ullot R., Rigol, S., Pinyot, J., Obiols P. (1989) Septic arthritis in children. Cir Pediatr (Spain), 2, 10–12Google Scholar
  37. Conte, G., Bacchiocchi, D., Jankovic, M. (1994) Brucellosis in childhood: therapeutic contribution. Miverva Pediatr, 46, 527–529Google Scholar
  38. Debono, J.E. (1964) Brucellosis simulating acute anteriorpoliomyelitis. Lancet, 1, 1132–1133Google Scholar
  39. De Los, M. and Del Rio, A. (1983) Brucella osteomyelitis. Pediatr. Infect. Dis. 2, 50–52Google Scholar
  40. Despert, F., Labes, B., Saillant, A. et al (1980) Les localisations rachidiennes de la melitococcie chez l’enfant. A propos d’un nouveau cas. Ann. Pediatr. (Paris), 27, 377–382Google Scholar
  41. Drutz, J.E. (1989) Brucellosis of the central nervous system. A case report of an infected infant. Clin Pediatr, 28, 476–478Google Scholar
  42. Elzouki, A.Y., Akhtar, M. and Mirza, K. (1996) Brucella endocarditin associated with glomerulonephritis and renal vasculitis. Paediatr. Nephrol (Germany), 10, 748–751Google Scholar
  43. Estevao, M.H., Barosa, L.M., Matos, L.M., Barroso, A.A., da Mota, H.C. (1995) Neurobrucellosis in children. Eur J Pediatr, 154,120– 122Google Scholar
  44. Fattah, H. and Khuffash, F. (1984) Reversible renal failure in a child with brucellosis. Ann. Trop. Paediatr., 4, 247–250PubMedGoogle Scholar
  45. Feiz, J., Sabbaghian, H. and Miralai, M. (1978) Brucellosis due to Brucella melitensis in children. Clin. Pediatr., 17, 904–907.Google Scholar
  46. Galanakis, E., Bourantas, K.L., et al. (1996) Childhood brucellosis in North-Western Greece: a retrospective analysis. Eur. J. Pediatr., 155, 1–6PubMedGoogle Scholar
  47. Gasser, I., Planes, A.M., Almirante, B., Fernandez-Perez, F. (1993) Brucella melitensis: another possible cause of breast abscess. Med Clin Bare, 100, 157Google Scholar
  48. Gedalia, A., Howard, C., Einhorn, M. (1992) Brucellosis induced avascular necrosis of the femoral head in a 7 year old child. Ann Rheum Dis, 51, 404–406PubMedGoogle Scholar
  49. Gomez-Reino, F., Mateo, I., Fuertes, A. and Gomez-Reino, J. (1986) Brucellar arthritis in children and its successful treatment with trimethoprim sulphamethoxazole (co-trimoxazole). Ann. Rheum. Dis., 45, 256–258PubMedGoogle Scholar
  50. Gori, E., Mannini, B., Pazzaglia, R., Bertini, V., Fioriti, M., Casadei, B.M. (1993) Osteoarthritis caused by Brucella melitensis: isolation of the microorganism from the synovial fluid. Pediatr Med Chir, 15, 625–627PubMedGoogle Scholar
  51. Gotuzzo, E. et al. (1987) Brucellar arthritis: A study of 39 Peruvian Families. Ann. Rheum. Dis., 46, 506–509PubMedGoogle Scholar
  52. Gotuzzo, E. et al (1982) Articular involvement in human brucellosis: a retrospective analysis of 304 cases. Semin. Arthritis Rheum., 12, 245–255PubMedGoogle Scholar
  53. Grasso, E., Mondino, P., Dalmasso, G. et al (1984) Two cases of brucellosis mastitis. G. Malatt. Infett. Parassit., 36, 1135–1138Google Scholar
  54. Guerra, R.R., Martinez, J.R. and Flores, L. (1982) Neurobrucellosis. Report of five cases and literature review. Rev. Invest. Clin. (Mex.), 34, 62–68Google Scholar
  55. Güvenc, H., Kocabay, K., Okten, A., Bektas, S. (1989) Brucellosis in a child complicated with multiple brain abscesses. Scand J Infect Dis, 21, 333–336PubMedGoogle Scholar
  56. Habeeb, Y.K., Al-Najdi, AK et al (1998), Paediatric neuro brucellosis: Case report and Literature review. J. Infect (England), 37, 59–62Google Scholar
  57. Hagebusch, O.E. and Frei, C.F. (1941) Undulant fever in children. Am. J. Clin. Pathol., 11, 497–515Google Scholar
  58. Hendricks, M.K., Perez, E.M., Burger, P.J., Mouton, P.A. (1995) Brucellosis in childhood in the Western Cape. S Afr Med J, 85, 176–178PubMedGoogle Scholar
  59. Howard, C.B., Alkrinawi, S., Gadalia, A., Mozes, M. (1993) Bone infection resembling phalangeal microgeodic syndrome in children. A case report. J Hand Surg Br, 18, 491–493PubMedGoogle Scholar
  60. Kalelioglu, M., Ceylan, S., Koksal, I., Kuzeyli, K., Akturk, E (Ï990) Brain abscess caused by Brucella abortus and Staphylococcus aureus in a child. Infection, 18, 386–387Google Scholar
  61. Kerem, E., Diav, O., Navon, P., Branski, D. (1994) Pleural fluid characteristics in pulmonary brucellosis. Thorax, 49, 89–90PubMedGoogle Scholar
  62. Khuri-Bulos, N.A., Daoud, A.H., Azab, S.M. (1993) Treatment of childhood brucellosis: results of a prospective trial on 113 children. Pediatr Infect Dis J, 12, 377–381PubMedGoogle Scholar
  63. Kristensen, M. (1929) La Position baacterioloque Bacillus abortus de Bang; Son importance Comme cause de maladie chez l’homme. Ann. Med., 26, 339–350Google Scholar
  64. Janbon, M. and de Kerleau, J.C. (1939) Brucellose humaine et avortement: isolement de brucella melitensis dans le sang de la mere, le visceras et le sand du foetus, le placenta, el les lochies. Presse. Med., 47, 453–455Google Scholar
  65. Labrune, P., Jabir, B., Magny, J.F., Guibert, M., Damay, M., Odievere, M. (1990) Recurrent enterocolitis-like symptoms as the possible present manifestations of neonatal Brucella melitensis infection. Acta Paediatr Scand (Sweden), 79, 707–709Google Scholar
  66. Loberant, N., Salamon, V., Jerushalmi, J., Herskovits, M., Goldfeld, M., Noi, I. (1995) Acute focal bacterial nephritis in childhood brucellosis. Pediatr Radiol, 25, S62–64PubMedGoogle Scholar
  67. Losurdo, G., Timitilli, A., Tasso, L., Carli, C., Ciuchini, F., Adone, R., Giacchino, R. (1994) Acute hepatitis due to brucella in a 2year old child. Arch Dis Child, 71, 387PubMedGoogle Scholar
  68. Lubani, M.M., Sharda, D. and Helin, I. (1986) Brucella arthritis in children. Infection, 14, 233–236.PubMedGoogle Scholar
  69. Lubani, M.M., Duddin, K.I. et al (1988) Neonatal brucellosis. Eur. J. Paediatr., 147, 520–522Google Scholar
  70. Lulu,.A.R., Araj, G.F., Khateeb, M.I. et al. (1988) Human brucellosis in Kuwait: a prospective study of 400 cases. Q. J. Med., 6, 39–54Google Scholar
  71. Lubani, M.M., Dudin, K.I., Araj, G.F., Manandhar, D.S., Rashid, F.Y. (1989) Neurobrucellosis in children. Pediatr Infect Dis J, 8, 79–82PubMedGoogle Scholar
  72. Madkour, M.M. (1989) Occupational related infectious arthritis. In BailliÀre’s Clinical Rheumatology: Occupational Rheumatic Diseases, vol. 3 (ed. G.P. Balint), W.B. Saunders, London, pp. 157–192Google Scholar
  73. Madkour, M.M., Mohamed, A., Talukder, M.A. and Kudwah, A. (1985) Brucellosis in Saudi Arabia. Saudi Med. J., 6, 324–332Google Scholar
  74. Madkour, M.M., Sharif, H.S., Abed, M.Y. AND Al Fayez, M.A. (1988) Osteoarticular brucellosis: results of bone scintigraphy in 140 patients. AJR, 150, 1101–1105PubMedGoogle Scholar
  75. Makarem, E.H. Karjoo, R. and Omidi, A. (1982) Frequency of Brucella melitensis in Southern Iran. J. Trop. Pediatr., 28, 97–100PubMedGoogle Scholar
  76. Makhseed, M., Harouny, A. et al (1998) Obstetric and Gynaecologic Implication of Brucellisis in Kuwait. J. Perinatol (USA), 18, 196–199Google Scholar
  77. Mckee, M.A. and Ballard, J.L. (1999) Mycotic aneurysm of the tibioperoneal arteries. Ann. Vase. Surg. (USA), 13, 188–190Google Scholar
  78. Miller, M.M. (1993) Persistent coccobacillary sepsis in a preterm newborn. Pediatr Infect Dis J, 12, 545–545–546Google Scholar
  79. Morrey, B.F., Banco, A.J. and Rhodes, K.H. (1976) Suppurative arthritis of the hip in children. J. Bone Joint Surg., 58A, 388–392PubMedGoogle Scholar
  80. Mousa, A.R., Koshy, T.S., Araj, G.F. et al. (1986) Brucella meningitis: presentation, diagnosis and treatment: a prospective study of ten cases. Q. J. Med., 60, 873–885PubMedGoogle Scholar
  81. Mousa, A.R., Muhtaseb, S.A., Almudallal, D.S. et al. (1987) Osteoarticular complications of brucellosis: a study of 169 cases. Rev. Infect. Dis., 9, 531–543PubMedGoogle Scholar
  82. Norton, W.L. (1984) Brucellosis and Rheumatic Syndrome in Saudi Arabia. Ann. Rheum. Dis., 43, 810–815PubMedGoogle Scholar
  83. O’Donoghue, A.F. (1933) Septic arthritis in the hip caused by Brucella melitensis. J. Bone Joint Surg., 15, 506–508Google Scholar
  84. Omar, F.Z., Zuberi, S., Minns, R.A. (1997) Neurobrucellosis in childhood: six new cases and a review of the literature. Dev Med Child Neurol, 39, 762–765PubMedGoogle Scholar
  85. Oran, O. et al (1983) Premature infant with Brucella abortus infection. Turk. J. Paediatr., 25, 139–142Google Scholar
  86. Patel, P.J. et al (1988) The chest radiograph in brucellosis. Clin. Radiol, 39, 39–41PubMedGoogle Scholar
  87. Poole, P.N. et al (1972) A case of abortion consequent upon infection with Brucella abortus type 2. J. Clin. Pathol, 26, 882–884Google Scholar
  88. Poston, M. and Thomson, R. (1936) Meningitis due to Brucella in a child. Am. J. Dis. Child., 52, 904–906Google Scholar
  89. Puri, P. and Harvey, T.W. (1981) Colonisation of ventriculoatrial shunt with B. abortus. Br. Med. J., 282, 1754–175Google Scholar
  90. Riestra, C.R., Gonzalez, G.A. et al. (1996) Brucellosis and Polyneuro-radiculo-myelo-encephalitis. A case report. Arch. Med. Res. (Mexico), 27, 331–333Google Scholar
  91. Rolin, B., Dumas, R. and Jean, R. (1980) Brucellose de l’enfant. Ann. Pediatr., 27, 371–375Google Scholar
  92. Rowen, J.I., Englund, J.A. (1995) Brucellosis presenting with cough. Pediatr Infect Dis J, 14, 721–722PubMedGoogle Scholar
  93. Ruiz, M.M., Bueno, C.C., Quero, F. et al (1978) Encephalopathie hepatique melitococcique. Arch. Fr. Pediatr., 35, 759–763Google Scholar
  94. Ruyssen, S., Le Pennec, M.P., Perreau, M. et al. (1983) Osteite « brucelies chez l’enfant. Arch. Fr. Pediatr., 40, 803–805PubMedGoogle Scholar
  95. Sabbaghian, J. and Nadim, A. (1974) Epidemiology of human brucellosis in Isfahan, Iran. J. Hyg. Camb., 73, 221–228Google Scholar
  96. Sanchez-Tamayo, T., Colmenero, J.D., Martinez-Cortes, F., Moreiras, A. (1997) Failure of short-term antimicrobial therapy in childhood brucellosis. Pediatr Infect Dis, 16, 323–324Google Scholar
  97. Sattarov, A.I. and Amireev, S.A. (1983) Some features of the epidemiology of brucellosis in children in the Kazakh SSR. Zh. Mikrobiol. Epidemiol Immunobiol, 9, 92–94PubMedGoogle Scholar
  98. Secmer, G., Ecevit, Z., Gulbulak, B., Ceyhan, M., Kanra, G., Anlar, Y. (1995) Splenic abscess due to brucella in childhood. A case report. Turk J Pediatr, 37, 403–406Google Scholar
  99. Shah P.M. and Joshi, V.G. (1967) Brucellosis in children. Indian Pediatr., 4, 226–231PubMedGoogle Scholar
  100. Shaher, E., Barzilay, Z., Shoher, I. et al. (1983) Elevated risk of osteoarticular complications in children with acute brucella melitensis infection. Acta Paediatr. Hung., 24, 263–267Google Scholar
  101. Shakir, R., Al-Din, A.S., Araj, G.F., Lulu, A.R., Mousa, A.R. and Saadah, M.A. (1987) Clinical categories of neurobrucellosis: a report on 19 cases. Brain, 110, 213–223PubMedGoogle Scholar
  102. Sharda, D.C. and Lubani, M. (1986) A study of brucellosis in childhood. Clin. Pediatr., 25, 492–495Google Scholar
  103. Shoshan, Y., Maayan, S. et al. (1996) Chronic subdural empyema: A new presentation of neurobrucellosis. Clin. Infect. Dis (USA), 23, 400–401Google Scholar
  104. Strannegard, I., Araj, G. and Fattah, H. (1985) Neurobrucellosis in an eight-year old child. Ann. Trop. Paediatr., 5, 191–194PubMedGoogle Scholar
  105. Street, L., Grant, W. and Alva, J. (1975) Brucellosis in children. Paediatrics, 55, 416–421Google Scholar
  106. Swick, H.M. (1981) Brucella meningoencephalitis in childhood. Neuropediatrics, 12, 330–336PubMedGoogle Scholar
  107. Tali, E.T., Keskin, T., Oznur, I.I., Simonson, T., Yuh, W.T. (1996) MRI of brucella polyneuritis in a child. Neuroradiology, 38, S190–192PubMedGoogle Scholar
  108. Titone, L., Romano, A. and Scarlata, F. (1985) Clinical and therapeutical features of brucellosis in children. G. Malatt. Infett. Parassit., 37, 372–374Google Scholar
  109. Tosi, M. and Nelson, J. (1983) Brucella canis infection in a 17-month old child successfully treated with moxalactam. J. Pediatr., 101, 725–727Google Scholar
  110. Ullrich, C.H., Fader, R., Fahner, J.B., Barbour, S.D. (1993) Brucellosis presenting as prolonged fever and hemophagocytosis. Am J Dis Child, 147, 1037–1038PubMedGoogle Scholar
  111. Vallejo, J.G., Stevens, A.M., Dutton, R.V., Kaplan, S.L. (1996) Hepatosplenic abscesses due to Brucella melitensis: report of a case involving a child and review of the literature. Clin Infect Dis, 22, 485–489PubMedGoogle Scholar
  112. Varón, E., Cohen, R., Bouhanna, C.A., Canet, J., Janaud, J.C., Geslin, P (1990) Brucellosis in a 3 month-old infant. Arch Fr Pediatr (France), 47, 587–590Google Scholar
  113. Wallis, H.R.E. (1957) Brucellosis in children. Br. Med. J. i 617–621Google Scholar
  114. Williamson, A.R. (1944) Abortions in Brucella abortus Fever. Br. Med. J., i, 752–756Google Scholar
  115. Yasar-Anlar, F., Yalcin, S., Seemeer, G. (1994) Persistent hypoglycorrhacia in neurobrucellosis. Pediatr Infect Dis J, 13, 747–748PubMedGoogle Scholar
  116. Zourbas, J., Masse, L., Roussey, A. et al. (1977) Sampling survey on brucellosis among farmers and the families in Ille-et-Villaine (Brittany). Int. J. Epidemiol, 6, 335–343PubMedGoogle Scholar

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  • M. Monir Madkour

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