Abstract
Localisation of brucellosis in the central nervous system, although uncommon, can have a devastating impact (Ambramsky 1977; Larbrisseau et al. 1978; Bashir et al. 1985; Mousa et al. 1986; Shakir et al. 1986 and 1987) with serious and permanent neurological deficits. Brucella melitensis is the most frequently encountered species in patients with neurobrucellosis, being the most invasive and most pathogenic. Other Brucella species have also been isolated including B. suis and B. abortus (Sumner 1950; Nichols 1951; Wochnik-Dyjas 1972a,b; Mousa et al. 1986). Neurobrucellosis maybe a presenting feature at the onset of the disease in the absence of other systemic manifestations of brucellosis. Neurobrucellosis may occur at any age (Debono 1964) and may present at any time during the course of active disease. Systemic features and localisations to other systems or body organs maybe present as well. In endemic areas, the detection of unexplained neurological findings should alert the treating physician to brucellosis as a possible cause.
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References
Abduljabbar, M.S. (1994) Adenosine deaminase concentration in cerebrospinal fluid during Brucella meningitis. J Infect., 29: 41–44.
Abd Elrazak, M. (1991) Brucella optic neuritis. Arch Intern Med (USA), 151, 776–778.
Abramsky, O. (1977) Neurological features as presenting manifestations of brucellosis. Eur. Neurol., 15, 281–285.
Al Abdely, H.M., Halim, M.A. and Amin, T.M. (1996) Breast abscess caused by Brucella melitensis. J Infect., 33, 219–220.
Al-Deeb, S.M., Yaqub, B.A., Sharif, H.S., Phadke, J.G. (1989) Neurobrucellosis: clinical characteristics, diagnosis, and outcome. Neurology, 39: 498–501.
Al-Eissa, Y.A., Al Herbish, A.A. (1996) Severe hypertension: an unusual presentation of Guillain-Barre syndrome in a child with brucellosis. Eur J Pediatr, 155: 53–55.
Al-Eissa, Y.A. (1993) Unusual suppurative complications of brucellosis in children. Acta Paediatr, 82, 987–992.
Al-Eissa, Y.A. (1995) Clinical and therapeutic features of childhood neurobrucellosis. Scand Infect Dis, 27, 339–343.
Al-Eissa, Y.A., Al-Zamil, F., et al. (1991) Childhood brucellosis: a deceptive infectious disease. Scand J Infect Dis (Sweden), 23, 129–133.
Al-Orainey, I.O., Laajam, M.A., Al-Aska, A.K., Rajapakee, C.N. (1987) Brucella meningitis. J Infect, 14: 141–145.
Anderson, H., Mortensen, A. (1992) Unrecognised neurobrucellosis giving rise to Brucella melitensis peritonitis via a ventriculoperitoneal shunt (letter). Eur J Clin Microbiol Infect Dis., 11: 953–954.
Ayala-Gaytan, J.J., Ortegon-Baqueiro, H., de la Maza, M. (1989) Brucella melitensis cerebellar abscess (letter). J Infect Dis. (United States), 160: 730–732.
Bahemuka, M., Shemena, A.R., Panayiotopoulos, C.P. et al. (1988) Neurological syndromes of brucellosis. J Neurol Neurosurg Psychiatry (England)., 51: 1017–1021.
Bashir, R., Al Kawi, M.Z., Harder, E.J. and Jinkins, J. (1985) Nervous system brucellosis: diagnosis and treatment. Neurology, 35, 1576–1581.
Brault, J. (1910) Fievre de Malte: Violente osteite du femur et du tibia gauches: vaste osteite de os du crane exo-et endocranienne. Gaz. Hôp., 83, 1335–1339.
Bruce, D. (1889) Observations on Malta Fever. Br. Med. J., i, 1101–1107.
Bucher, A., Gaustad, P., Pape, E. (1990) Chronic neurobrucellosis due to Brucella melitensis. Scand J Infect Dis (Sweden)., 22: 223–236.
Bussone, G., La Mantia, L., Grazzi, L. et al. (1989) Neurobrucellosis mimicking multiple sclerosis: a case report. Eur Neurol (Switzerland), 29: 238–240.
Cavallaro, N., Randone, A., La-Rosa, L., Mughinin, L. (1990) Bilateral papilledema in a patient with brucellosis. Metab Pediatr Syst Ophthalmol, 13: 115–118.
Challoner, K.R., Riley, K.B., Larsen, R.A. (1990) Brucella meningitis. Am J Emerg Med., 8: 40–42.
Chowdhary, U.M., Twum-Danso, K. (1991) Brucella meningoen-cephalitis associated with cerebrospinal fluid shunt in a child: case report. Surg Neurol, 35: 468–471.
Chowdhary, U.M., Twum-Danso, K. (1991) Brucella meningoen-cephalitis associated with cerebrospinal fluid shunt in a child: case report. Surg Neurol (United States), 35: 468–470.
da-Cunha, S. (1995) Adenosine deaminase in cerebrospinal fluid during brucella meningitis (letter). J Infect., 31: 82–83.
da-Cunha, S., Gaspar, E., Melico-Silvestre, A., Azlvedo-Bernarda, R., da-Costa, C. (1990) Neurobrucellosis—another cause of increased adenosine deaminase activity in cerebrospinal fluid (letter). J Infect Dis., 161: 156–157.
Debono, J.E. (1964) Brucellosis simulating acute anterior poliomyelitis. Lancet, i, 1132–1133.
Diab, S.M., Araj, G.F., Al Asfour, A.J., Al Yusuf, A.R. (1989) Brucellosis: atypical presentation with peritonitis and meningitis. Trop Geogr Med (Netherlands), 41: 160–163.
Dias, M.S., Morganho, A., Passao, V., Aguiar, T., Pedrosa, R. (1995) Neurobrucellosis. Report of 8 cases. Acta Med Port., 8: 671–675.
Dixon, G.J. and Roaf, R. (1946) Undulant fever complicated by acute transient attacks of aphasia and during convalescence, by deafness, tinnitus and paraesthesia. Br. Med. J., ii, 12–13.
Drutz, J.E. (1989) Brucellosis of the central nervous system. A case report of an infected infant. Clin Pediatr, (Phila) (United States)., 28: 476–478.
Elidan, J., Michel, J., Gray, I. and Springer, H. (1985) Ear involvement in human brucellosis. J. Laryngol. Otol, 99, 289–291.
Estevao, M.H., Barosa, L.M., Matos, L.M., Barroso, A.A., da-Mota, H.C. (1995) Neurobrucellosis in children. Eur J Pediatr, 154: 120–122.
Eyre, J.W.H. (1908) Melitensis septicaemia (Malta or Mediterranean Fever). Lancet, i, 1747–1752.
Fincham, R.W., Sahs, A.L. and Joynt, R.J. (1963) Protean manifestations of nervous system brucellosis. JAMA, 184, 269–275.
Galle, C., Struelens, M., Liesnard, C. et al. (1997) Brucella melitensis osteitis following craniotomy in a patient with AIDS. Clin Infect Dis., 24: 1012.
Garcia, T., Sanchez, J.C., Maestre, J.F. et al. (1989) Brucellosis and acute inflammatory polyradiculoneuropathy. Neurolgia (Spain), 4: 145–147.
Gasser, I., Planes, A.M., Almirante, B. and Fernandez-Perez, F. (1993) Brucella melitensis: another possible cause of breast abscess (letter). Med Clin Barc., 100, 157.
Grammont-Cuppillard, M., Berthet-Badetti, L., Dellamonica, P. (1996) Brucellosis from sniffing bacteriological cultures (letter). Lancet., 348: 1733–1734.
Guvenc, H., Kocabay, K., Okten, A., Bektas, S. (1989) Brucellosis in a child complicated with multiple brain abscesses. Scand Infect Dis., 21: 333–336.
Hansmann, G.H. and Schenken, J.R. (1932) Melitensis meningo-encephalitis. Mycotic aneurysm due to Brucella melitensis var. porcine. Am. J. Pathol., 8, 435–443.
Hughes, M.L. (1897) Mediterranean, Malta or Undulant Fever, Macmillan, London, p. 124.
Imboden, J.B., Canter, A., Cluff, L.E. and Trever, R.W. (1959) Brucellosis II. Psychological aspects of delayed convalescence. Arch. Intern. Med., 103, 406–414.
Kalelioglu, M., Ceylan, S., Koksal, I., Kuzeyli, K., Akturk, F. (1990) Brain abscess caused by Brucella abortus and Staphylococcus aureus in a child. Infection., 18: 386–387.
Kassur, B., Knap, J. and Dziubek, Z. (1983) Mental disorders in acute and subacute brucellosis. Psychiatr. Pol., 4, 281–286.
Khuraibet, A.J., Shakir, R.A., Trontelj, J.V., Butinar, D., Al-Din, A. S. (1988) Brainstem auditory evoked potential (BAEP) abnormalities in brucellosis. J Neurol Sci., 87: 307–313.
Larbrisseau, A., Marvi, E., Aguilera, F. and Martinez-Lage, J.M. (1978) The neurological localizations of brucellosis. Can. J. Neurol. Sci., 5, 369–376.
Lopez-Cortes, L.F., Cruz-Ruiz, M., Gomez-Mateos, J. et al. (1995) Adenosine deaminase activity in the CSF of patients with aseptic meningitis: utility in the diagnosis of tuberculous meningitis or neurobrucellosis. Clin Infect Dis., 20: 525–530.
Lowe, G.H. and Lipscomb, P.R. (1947) Brucellosis osteomyelitis. Report of two cases in which shafts of the long bones were involved. Surgery, 22, 525–529.
Lubani, M.M., Dudin, K.I., Araj, G.F., Manandhar, D.S., Rashid, F.Y. (1989) Neurobrucellosis in children. Pediatr Infect Dis J., 8: 79–82.
Lulu, A.R., Araf. G.F., Khateeb, M.I et al. (1988) Human brucellosis in Kuwait: a prospective study of 400 cases. Q. J. Med., 66, 39–54.
Madkour, Monir, M. Brucellosis (1996) In: Weatherall, D.J., Ledingham, J.G. and Warrell, D.A. Eds. Oxford Textbook of Medicine, 3rd Edition. Oxford: Oxford University Press, 619–623.
Madkour, Monir, M., Rahman, A., Talukder, M. and Kudwah, A. (1985) Brucellosis in Saudi Arabia. Saudi Med. J., 6, 324–332.
Madkour, Monir. M. Brucellosis (1998) In: Fauci, A.S., Braunwald, E., Isselbacher, K.J. et al. Eds. Harrison’s Principles of Internal Medicine 14th Edition. New York: McGraw Hill, 969–971.
Martin Escudero, J.C., Gil Gonzalez, M.I., Aparicio Blanco, M. (1990) Intracranial hypertension and subarachnoid hemorrhage: the forms of presentation of neurobrucellosis. An Med Interna (Spain), 7: 358–360.
Martin, I., Ramos, C., Gutierrez, A., Arazo, P., Aguirre, J.M. (1992) HIV infection and chronic brucellosis (letter). Enferm Infecc Microbiol Clin., 10: 566–567.
Marzo-Sola, M.E., Calderon-Giron, C., Ayuso-Blanco, T. et al. (1995) Neurobrucellosis. A report of 13 cases. Neurolgia, 10: 375–379.
Mathur, T.N. (1955) Sciatica in brucellosis. Ind. J. Med. Sci., 9, 692–694.
McLean, D.R., Russell, N., Khan, M.Y. (1992) Neurobrucellosis: clinical and therapeutic features. Clin Infect Dis (United States), 15: 582–590.
Merello, F., Cagnin, G., Antonino, D. and Toso, V. (1981) A case of brucellosis localised in the brain. Riv. Neurobiol., 27, 34–39.
Meyers, D. (1994) Psychosocial factors and somatisation in chronic fatigue and allied disorders (letter). Med J. Aust. 160: 806–807.
Mikic, D., Kapulica, I., Lako, B., Marinkovic, V., Mijuskovic, P. (1993) Brucella meningitis. Vojnosanit-Pregl., 50: 630–633.
Montejo, F., Merino, J., Alberola, I., Martinez, E., Noguerales, F. and Aguirre, C. (1983) Absceso epidural brucelosico. Med. Clin. (Barc.), 80, 187–188.
Mousa, A.M., Koshy, T.S., Araf, G.F. et al. (1986) Brucellosis meningitis: presentation and treatment—a prospective study of ten cases. Q. J. Med., 60, 873–885.
Murrell, T.G., Matthews, B.J. (1990) Multiple sclerosis-one manifestation of neurobrucellosis? Med Hypotheses (England), 33: 43–48.
Nencyz-Graviec, Z. and Fabian, F. (1981) A case of primarily chronic brucellosis with symptoms of multiple sclerosis. Przegl. Epidemiol., 35, 521–524.
Nichols, E. (1951) Meningo-encephalitis due to brucellosis with the report of a case in which B. abortus was recovered from the cerebrospinal fluid, and a review of the literature. Ann. Intern. Med., 35, 673–693.
Oliveri, R.I., Matera, G., Foca, A., et al. (1996) Polyradiculoneuropathy with cerebrospinal fluid albuminocytological dissociation due to neurobrucellosis. Clin Infect Dis., 23: 833–834.
Omar, F.Z., Zuberi, S., Minns, R.A. (1997) Neurobrucellosis in childhood: six new cases and a review of the literature. Dev Med Child Neurol., 39: 762–765.
Omasits, M., Brainin, M, (1987) Primary chronic neurobrucellosis. Fortschr Neurol Psychiatr (Germany, West)., 55: 291–293.
Pascual, J., Combarros, O., Polo, J.M., Berciano, J. (1988) Localized CNS brucellosis: report of 7 cases. Acta Neurol Scand. 78: 282–289.
Pedro-Pons, A., Foz, M., Codina, A., Rey, C. (1972) Les neurobrucelloses (étude de 41 cas). Europa. Med., 13, 855–862.
Povar, J., Aguirre, J.M., Arazo, P., et al. (1991) Brucellosis with nervous system involvement. An Med Interna (Spain)., 8: 387–390.
Puri, P. and Harvey, T.W. (1981) Colonisation of ventriculo-atrial shunt with Brucella abortus. Br. Med. J., 282, 1754–1755.
Roldan-Montaud, A., Jimenez-Jimenez, F.J., Zancada, F. (1991) Neurobrucellosis mimicking migraine. Eur Neurol (Switzerland), 31: 30–32.
Sahadeven, M.G., Singh, M., Joseph, P.P. and Hoon, R.S. (1968) Meningo-myelitis due to brucellosis. Br. Med. J., 4, 432–433.
Sanchez-Rodriguez, A., Martin-Oterino, J.A., Fidalgo-Fernandez, M.A. (1997) Brucellar meningitis as a peculiar form of clear fluid meningitis. Clinical study. Rev Clin Esp., 197: 623–626.
Santini, C., Baiocchi, P., Berardelli, A., Venditti, M., Serra, P. (1994) A case of brain abscess due to Brucella melitensis (letter). Clin Infect Dis., 19: 977–978.
Shakir, R.A. (1986) Neurobrucellosis. Postgrad. Med. J., 62, 1077–1079.
Shakir, R.A., Al-Din, A.S.N., Arag, G.F., Lulu, A.R., Mousa, A.R. and Saadah, M.A. (1987) Clinical categories of neuro-brucellosis. A report of 19 cases. Brain, 110, 213–223.
Shoshan, Y., Maayan, S., Gomori, M.J., Israel, Z. (1996) Chronic subdural empyema: a new presentation of neurobrucellosis. Clin Infect Dis., 23: 400–401.
Stendler, A. (1940) Orthopedic localizations of brucellosis. J. Iowa. Med. Soc., 30, 256–257.
Strannegard, I., Araj, G.F. and Fattah, H.A. (1985) Neurobrucellosis in an 8-year-old child. Ann. Trop. Paediatr., 5, 191–194.
Sumner, J.W. (1950) Epidural abscess secondary to brucellosis (Brucella suis). US Armed Forces Med. J., 1, 218–221.
Swick, H.M. (1981) Brucella meningo-encephalitis in childhood. Neuropediatrics, 12, 330–336.
Tali, E.T., Keskin, T., Oznur, I.I., Simonson, T., Yuh, W.T. (1996) MRI of brucella polyneuritis in a child. Neuroradiology., 38 Suppl 1: S190–192.
Thomas, R., Kameswaran, M., Murugan, V., Okafor, B.C. (1993) Sensorineural hearing loss in neurobrucellosis J Laryngol Otol., 107: 1034–1036.
Walus, M.A., Young, E.J. (1990) Concomitant neurocysticercosis and brucellosis. Am J Clin Pathol (United States), 94: 790–792.
Wochnik-Dyjas, D. and Dziubek. Z. (1972a) Neurological disorders in chronic brucellosis. I. Neurological symptoms. Epidemiol. Rev., 26, 22–28.
Wochnik-Dyjas, D. and Dziubek. Z. (1972b) Neurological disorders in chronic brucellosis. II. Neurological signs. Epidemiol. Rev., 26, 29–35.
Yaqub, B.A., Kabiraj, M.M., Shamena, A. et al. (1992) Diagnostic role of brain-stem auditory evoked potentials in neurobrucellosis. Electroencephalogr Clin Neurophysiology (Ireland)., 84: 549–552.
Yasar-Anlar, F., Yalcin, S., Secmeer, G. (1994) Persistent hypoglycorrhachia in neurobrucellosis. Pediatr Infect Dis J., 13: 747–748.
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Madkour, M.M., Al-Moutaery, K.R., Al-Deeb, S., Al-Swailem, R., Al-Okaily, F. (2001). Neurobrucellosis. In: Madkour’s Brucellosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59533-2_15
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