Abstract
References to biological disturbances as the basis of specific psychiatric disorders can be found in works from as early as the Corpus Hippocratum dating back to the fifth century B.C. Within this context and in keeping with humoral theory, psychological disorders were also ascribed to an imbalance (dyscrasia) of black and yellow bile, mucus and blood, with melancholy being attributed to a predominance of black bile, pointing, once again, to a humoral interpretation of psychiatric abnormalities. In contrast to this scholastic approach to medicine, Paracelsus (1491–1541), who also laid the foundations for the development of iatrochemistry (which gained particular importance during the seventeenth century), saw the human body as a chemical system whose ailments could therefore also be cured using chemical compounds. His findings concerning the relationship between struma and cretinism first pointed to endocrinological changes in association with psychiatric disorders.
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Heuser, I. (2001). Psychoneuroendocrinology. In: Henn, F., Sartorius, N., Helmchen, H., Lauter, H. (eds) Contemporary Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59519-6_8
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DOI: https://doi.org/10.1007/978-3-642-59519-6_8
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