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Molecular Genetics and Molecular Biology of Alzheimer’s Disease

  • R. Sandbrink
  • K. Beyreuther

Abstract

Basic research on the molecular biology of Alzheimer’s disease began with the study of the characteristic histopathological features of the disease, which revealed that β-amyloid (Aβ), amyloid precursor protein (APP), and tau protein all participate in the disease process at the molecular level. The molecular genetic characterization of the various genetic etiologies of the disease then led not only to confirmation that Aβ is important in pathogenesis, but also to the identification of further genes and gene products involved in the production of Alzheimer’s disease — the presenilins and apolipoprotein E, whose ε4 allele is a risk factor for the disease.

Keywords

Alzheimer Disease Amyloid Precursor Protein Amyloid Precursor Protein Gene Amyloid Precursor Protein Expression Hereditary Cerebral Hemorrhage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • R. Sandbrink
  • K. Beyreuther

There are no affiliations available

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