Skip to main content
SpringerLink
Log in

Neutropene Kolitis und „Graft-versus-Host-Disease“ (GvHD)

  • Conference paper
Chronisch entzündliche Darmerkrankungen

Part of the book series: Gastroenterologie Update ((GASTROUPDATE,volume 2001))

  • 53 Accesses

Zusammenfassung

In der Therapie maligner Erkrankungen können toxische Chemotherapien oder Bestrahlungen und deren Kombinationen zu einer akuten Schädigung des Darmepithels mit Abflachung des Epithels und bisweilen bis zum Untergang kompletter intestinaler Krypten und Atypien der Kryptenzellkerne führen. Diese Veränderungen werden klinisch manifest durch krampfartige abdominelle Schmerzen, begleitet durch wässrige Diarrhöen und Gewichtsverlust. Die akute Schädigung ist in der Regel reversibel und es kommt zu einer Normalisierung der Epithelzellschicht nach etwa 16–18 Tagen. Bei anhaltender Granulozytopenie kann es dann zu einer Sonderform einer intestinalen Entzündung, der so genannten neutropenen Kolitis kommen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Asai O, Longo DL, Tian ZG, Hornung RL, Taub DD, Ruscetti FW, Murphy WJ(1998) Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation. J Clin Invest 101:1835–1842

    Article  PubMed  CAS  Google Scholar 

  • Asplund S, Gramlich TL (1998) Chronic mucosal changes of the colon in graft-versushost disease. Mod Pathol 11:513–515

    PubMed  CAS  Google Scholar 

  • Baker KS, Allen RD, Roths JB, Sidman CL (1995) Kinetic and organ-specific patterns of cytokine expression in acute graft-versus-host disease. Bone Marrow Transplant 15:595–603

    Article  PubMed  CAS  Google Scholar 

  • Blijlevens NM, Donnelly JP, De Pauw BE (2000) Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview. Bone Marrow Transplant 25:1269–1278

    Article  PubMed  CAS  Google Scholar 

  • Brown GR, Lindberg G, Meddings J, Silva M, Beutler B, Thiele D (1999) Tumor necrosis factor inhibitor ameliorates murine intestinal graft- versus-host disease. Gastroenterology 116:593–601

    Article  PubMed  CAS  Google Scholar 

  • Clark R (1995) Neutropenic colitis (typhlitis). Cancer Control 2:522

    PubMed  Google Scholar 

  • Donnelly LF, Morris CL (1996) Acute graft-versus-host disease in children: abdominal CT findings. Radiology 199:265–268

    PubMed  CAS  Google Scholar 

  • Entzian D, Mayo-Smith WW (2000) Typhlitis. Med Health R I 83:359

    CAS  Google Scholar 

  • Ettinghausen SE (1993) Collagenous colitis, eosinophilic colitis, and neutropenic colitis. Surg Clin North Am 73(5):993–1016

    PubMed  CAS  Google Scholar 

  • Fowler DH, Breglio J, Nagel G, Eckhaus MA, Gress RE (1996) Allospecific CD8+ Tcl and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease. J Immunol 157:4811–4821

    PubMed  CAS  Google Scholar 

  • Galvao FH, Ye Q, Doughton C, Murase N, Todo S, Zeevi A, Waitzberg D, Fung JJ, Starzl TE (1997) Experimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies. Transplant Proc 29:700

    Article  PubMed  CAS  Google Scholar 

  • Hill GR, Cooke KR, Teshima T, Crawford JM, Keith JC Jr, Brinson YS, Bungard D, Ferrara JL (1998) Interleukin-11 promotes T-cell polarization and prevents acute graftversus-host disease after allogenic bone marrow transplantation. J Clin Invest 102:115–123

    Article  PubMed  CAS  Google Scholar 

  • Hoffman RA, Nussler NC, Gleixner SL, Zhang G, Ford HR, Langrehr JM, Demetris AJ, Simmons RL (1997) Attenuation of lethal graft-versus-host disease by inhibition of nitric oxide synthase. Transplantation 63:94–100

    Article  PubMed  CAS  Google Scholar 

  • Koltun WA, Bloomer MM, Colony P, Kauffman GL (1996) Increased intestinal permeability in rats with graft versus host disease. Gut 39:291–298

    Article  PubMed  CAS  Google Scholar 

  • Kraus MD, Shahsafaei A, Antin J, Odze RD (1998) Relationship of Bd-2 expression with apoptosis and proliferation in colonic graft versus host disease. Hum Pathol 29:869–875

    Article  PubMed  CAS  Google Scholar 

  • Langrehr JM, Machens C, Zill E, Leder K, Neuhaus PJ (1999) Inhibition of nitric oxide synthesis reduces bacterial translocation during graft-versus-host disease after small bowel transplantation. Transplant Proc 31:574

    Article  PubMed  CAS  Google Scholar 

  • Monteiro JA, Martins TV, Morgado A (1994) Typhlitis. Acta Med Port 7:39–41

    PubMed  CAS  Google Scholar 

  • Neumann U, Knoop M, Langrehr JM et al. (1995) Graft-vs.-host reaction: a severe complication after orthotopic liver transplantation. Zentralbi Chir 120:478–481

    CAS  Google Scholar 

  • Nikolic B, Lee S, Bronson RT, Grusby MJ, Sykes M (2000) Thi and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest 105:1289–1298

    Article  PubMed  CAS  Google Scholar 

  • Ponec RJ, Hackman RC, McDonald GB (1999) Endoscopic and histologic diagnosis of intestinal graft-versus-host disease after marrow transplantation. Gastrointest Endosc 49:612–621

    Article  PubMed  CAS  Google Scholar 

  • Poritz LS, Page MJ, Tilberg AF, Koltun WA (1998) Amelioration of graft versus host disease with anti-ICAM-1 therapy. J Surg Res 80:280–286

    Article  PubMed  CAS  Google Scholar 

  • Poritz LS, Page MJ, Tilberg AF, Olt G, Ruggiero FM, Koltun WA (1998) Monoclonal antibody to lymphocyte function associated antigen-1 improves graft-versus-host disease. Dis Colon Rectum 41:299–309

    Article  PubMed  CAS  Google Scholar 

  • Sakai T, Kimura Y, Inagaki-Ohara K, Kusugami K, Lynch DH,Yoshikai Y (1997) Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graftversus-host disease in mice. Gastroenterology 113: 168–174

    CAS  Google Scholar 

  • Sawamura SA, Tanaka K, Noda S, Koga Y (1999) The role of intestinal bacterial flora in the tuning of the T-cell repertoire. Immunobiology 201:120–132

    PubMed  CAS  Google Scholar 

  • Schattenfroh NC, Hoffman RA, McCarthy SA, Simmons RL (1995) Phenotypic analysis of donor cells infiltrating the small intestinal epithelium and spleen during graftversus-host disease. Transplantation 59:268–273

    PubMed  CAS  Google Scholar 

  • Sirolimus. AY 22989, NSC 226080, NSC 606698, Rapamycin, Rapamune (1999) Drugs R D 1:100–107

    Google Scholar 

  • Sloas MM, Flynn PM, Kaste SC, Patrick CC (1993) Typhlitis in children with cancer: a 30-year experience. Clin Infect Dis 17(3):484–490

    Article  PubMed  CAS  Google Scholar 

  • Tanaka T, Ohtsuka Y,Yagita H, Shiratori Y, Omata M, Okumura K (1995) Involvement of alpha 1 and alpha 4 integrins in gut mucosal injury of graft-versus-host disease. Int Immunol 7:1183–1189

    CAS  Google Scholar 

  • Urbach DR, Rotstein OD (1999) Typhlitis. Can J Surg 42:415–419

    PubMed  CAS  Google Scholar 

  • Vogelsang GB (2000) Advances in the treatment of graft-versus-host disease. Leukemia 14:509–510

    Article  PubMed  CAS  Google Scholar 

  • Waaga AM, Fandrich F, Krzymanski M, Eckstein V, Herwartz C, Muller-Ruchholtz W, Russell ME (1996) 15-Deoxyspergualin downregulates MHC class II antigen expression and cell migration in models of graft-versus-host and host-versus-graft disease. Transplant Proc 28:2515–2517

    Google Scholar 

  • Worawattanakul S, Semelka RC, Kelekis NL, Sallah AS (1996) MR findings of intestinal graft-versus-host disease. Magn Reson Imaging 14:1221–1223

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. Hoffmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik II, Universitätsklinikum Frankfurt am Main, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Deutschland

    Jürgen Stein

  2. Virchow-Kliniken, Universitätsklinikum der Humboldt-Universität, Augustenburger Platz 1, 13353, Berlin, Deutschland

    Axel Dignass

  3. Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Universitätsklinikum Charité, Augustenburger Platz 1, 13353, Berlin, Deutschland

    Axel Dignass

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hoffmann, P. (2001). Neutropene Kolitis und „Graft-versus-Host-Disease“ (GvHD). In: Stein, J., Dignass, A. (eds) Chronisch entzündliche Darmerkrankungen. Gastroenterologie Update, vol 2001. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59505-9_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59505-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42509-0

  • Online ISBN: 978-3-642-59505-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation