Gentamicin Release from PMMA Bone Cement: Mechanism and Action on Bacteria

  • Lars Frommelt
Conference paper

Abstract

Antibiotic-loaded bone cement (ALAC) is used widely today in the therapy of periprosthetic infection and other infectious conditions of bone tissue.

Keywords

Porosity Peri Vancomycin Methacrylate Gentamicin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Charnley J (1964) A clean-air operating enclosure. Brit J Surgery 51: 195–202CrossRefGoogle Scholar
  2. 2.
    Buchholz HW, Elson RA, Engelbrecht E, Lodenkämper H, Röttger J, Siegel A (1981) Management of deep infection of total hip replacement. J Bone Joint Surg 63B: 342–353Google Scholar
  3. 3.
    Buchholz HW, Engelbrecht H (1970) Über die Depotwirkung einiger Antibiotika bei Vermischung mit dem Kunstharz Palacos. Chirurg 41: 511–515PubMedGoogle Scholar
  4. 4.
    Buchholz HW, Elson RA, Lodenkämper H (1979) The infected joint implant. In: McKibbin B (ed) Recent Advances in Orthopaedics 3. Churchill Livingston, New York, pp. 139–161Google Scholar
  5. 5.
    Klemm K (1979) Gentamicin-PMMA-Kugeln in der Behandlung abszedierender Knochen-und Weichteilinfektionen. Zbl Chir 104: 934–942PubMedGoogle Scholar
  6. 6.
    Lindner B (1981) Physikalische Analyse des Freisetzungsmechanismus von Chemotherapeutika aus dotiertem Polymethylmetacrylat. Inauguraldissertation. Kiel, GermanyGoogle Scholar
  7. 7.
    Low HT, Fleming RH, Gilmore MFX, McCarthy ID, Hughes SPF (1986) In vitro measurement and computer modelling of the diffusion of antibiotic in bone cement. J Biomed Eng 8: 149–155CrossRefGoogle Scholar
  8. 8.
    Adam K, Couch L, Cierny G, Calhoun J, Mader JT (1992) In vitro and in vivo evaluation of antibiotic-impregnated polymethylmethacrylate beads. Clin Orthop 278: 244–252Google Scholar
  9. 9.
    Gristina AG (1987) Biomaterial-centered infection: microbial adhesion versus tissue integration. Science 237: 1588–1595PubMedCrossRefGoogle Scholar
  10. 10.
    Frommelt L (2000) Periprosthetic infection - bacteria and the interface between prosthesis and bone. In: Learmonth ID (ed) Interfaces in total hip arthroplasty. Springer, LondonGoogle Scholar
  11. 11.
    Brisou JF (1995) Biofilms - methods of enzymatic release of micro organisms. CRC Press, Boca RatonGoogle Scholar
  12. 12.
    Zak O, Sande MA (1982) Correlation of in vitro activity of antibiotics with results of treatment in experimental animal models and human infection. In: Sabath LD (ed) Action of antibiotics in patients. Hans Huber Publishers, Bern, pp. 55–67Google Scholar
  13. 13.
    Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM (1995) Microbial biofilms. Annu Rev Microbiol 49: 711–745PubMedCrossRefGoogle Scholar
  14. 14.
    Lidwell OM (1988) Air, antibiotics and sepsis in replacement joints. J Hosp Inf 11 [Suppl C]: 18–40CrossRefGoogle Scholar
  15. 15.
    Josefson G, Kolmert L (1993) Prophylaxis with systemic antibiotics versus gentamicin bone cement in total hip arthroplasty. A ten-year survey of 1,688 hips. Clin Orthop 292: 210–214Google Scholar
  16. 16.
    McDonald DJ, Fitzgerald RH, Ilstrup DM (1989) Two-stage reconstruction of a total hip arthroplasty because of infection. J Bone Joint Surg 71-A: 828–834Google Scholar
  17. 17.
    McMaster WC (1995) Technique for intraoperative construction PMMA spacers in total knee revision. Am J Orthop 24: 178–180PubMedGoogle Scholar
  18. 18.
    Oxborrow NJ, Stamer J, Andrews M, Stone MH (1997) New uses for gentamicin impregnated polymethyl methacrylate in two-stage revision hip arthroplasty. J Arthroplasty 12: 709–710PubMedCrossRefGoogle Scholar
  19. 19.
    Steinbrink K, Frommelt L (1995) Behandlung der periprothetischen Infektion der Hüfte durch einzeitige Austauschoperation. Orthopäde 24: 335–343PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Lars Frommelt

There are no affiliations available

Personalised recommendations