Augmented Acute Normovolemic Hemodilution

  • D. R. Spahn
  • P. F. X. Willimann
  • N. S. Faithfull
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine 2001 book series (YEARBOOK, volume 2001)


The avoidance of allogeneic blood transfusions is an important goal in the peri-operative care of surgical patients because allogeneic blood transfusions have adverse effects, impose high costs, and may have questionable efficacy [1, 2]. Adverse effects include acute reactions, transmission of infectious diseases, immunosuppression, and the syndrome of transfusion related acute lung injury (TRALI) [1].


Blood Loss Allogeneic Blood Operative Blood Loss Allogeneic Blood Transfusion Allogeneic Transfusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Spahn DR, Casutt M (2000) Ehminating blood transfusions: New aspects and perspectives. Anesthesiology 93:242–255PubMedCrossRefGoogle Scholar
  2. 2.
    Hebert PC, Wells G, Blajchman MA, et al (1999) A multicenter, randomized, controlled chnical trial of transfusion requirements in critical care. N Engl J Med 340:409–417PubMedCrossRefGoogle Scholar
  3. 3.
    Spahn DR, van Bremt R, Theilmeier G, et al (1999) Perflubron emulsion delays blood transfusion in orthopedic surgery. Anesthesiology 91:1195–1208PubMedCrossRefGoogle Scholar
  4. 4.
    Tremper KK (1999) Perfluorochemical “Blood Substitutes” indications for an oxygen carrying colloid. Anesthesiology 91:1185–1187PubMedCrossRefGoogle Scholar
  5. 5.
    Lamy ML, Daily EK, Brichant JF, et al (2000) Randomized trial of Diaspirin cross-hnked hemoglobin solution as an alternative to blood transfusion after cardiac surgery. Anesthesiology 92: 646–656PubMedCrossRefGoogle Scholar
  6. 6.
    Levy JH (2000) Hemoglobin-based oxygen-carrying solutions: close but still so far. Anesthesiology 92:639–641PubMedCrossRefGoogle Scholar
  7. 7.
    Vlahakes GJ (2000) Hemoglobin solutions come of age. Anesthesiology 92:637–638PubMedCrossRefGoogle Scholar
  8. 8.
    Klein HG (2000) The prospects for red-cell substitutes. N Engl J Med 342:1666–1668PubMedCrossRefGoogle Scholar
  9. 9.
    Spahn DR (1999) Blood substitutes: artificial oxygen carriers: perfluorocarbon emulsions. Crit Care 3:R93–R97PubMedCrossRefGoogle Scholar
  10. 10.
    Stehhng L (1999) Autologous transfusion. In: Miller RD (ed) Anesthesia. Churchill Livingstone, Philadelphia, pp 1645–1662Google Scholar
  11. 11.
    Gould SA, Moore EE, Hoyt DB, et al (1998) The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. J Am Coll Surg 187: 113–120PubMedCrossRefGoogle Scholar
  12. 12.
    Egli GA, Zollinger A, Seifert B, Popovic D, Pasch T, Spahn DR (1997) Effect of progressive hae-modilution with hydroxyethyl starch, gelatin and albumin on blood coagulation. An in vitro thrombelastography study. Br J Anaesth 78:684–689PubMedGoogle Scholar
  13. 13.
    Sloan EP, Koenigsberg M, Gens D, et al (1999) Diaspirin cross-linked hemoglobin (DGLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial. JAMA 282:1857–1864PubMedCrossRefGoogle Scholar
  14. 14.
    Keipert PE (1998) Perfluorochemical emulsions: Future alternatives to transfusion. Blood Subst Princ Meth Prod Clin Trials 2:127–156Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • D. R. Spahn
  • P. F. X. Willimann
  • N. S. Faithfull

There are no affiliations available

Personalised recommendations