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Translating Experimental Stroke Research into the Clinical Arena

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Maturation Phenomenon in Cerebral Ischemia IV

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Summary

Over the past 15 years significant progress has been made in our understanding of the pathophysiology of experimental cerebral ischemia. Using examples primarily from our Stanford experience, I review the development of several neuroprotective strategies, including the use of NMDA antagonists and mild hypothermia as well as the application of these agents in the operating room and in clinical trials for stroke. The usefulness of evoked potential monitoring for the detection of early and reversible cerebral ischemia in the laboratory was quickly integrated into the clinical setting within the operating room. The clinical problem of intraoperative interrupted vs. non-interrupted temporary arterial occlusion was investigated experimentally in the laboratory. Advances in experimental neuro- imaging were applied to clinical decision making. The success of thrombolytic treatment for acute stroke patients is discussed. Finally, the use of gene transfer therapy for treating cerebral ischemia will be covered.

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© 2001 Springer-Verlag Berlin Heidelberg

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Steinberg, G.K. (2001). Translating Experimental Stroke Research into the Clinical Arena. In: Maturation Phenomenon in Cerebral Ischemia IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59446-5_30

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  • DOI: https://doi.org/10.1007/978-3-642-59446-5_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41107-9

  • Online ISBN: 978-3-642-59446-5

  • eBook Packages: Springer Book Archive

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