Summary
Permanent middle cerebral artery (MCA) occlusions induce hypoxia-inducible factor-1 (HIF-lα) in cingulate cortex, a region postulated to have reduced blood flow and oxygen delivery due to the MCA occlusions. To test this, exposure of adult animals to 6–8% oxygen for 6 h was shown to induce both hypoxia-inducible factor-1 (HIF-1) and its target gene, erythropoietin. Hypoxic preconditioning in neonatal animals (8% oxygen for 3 h), a treatment that protects newborn brain against hypoxic-ischemic injury, also induces HIF-1. To further support a role for HIF in protection, systemic administration of cobalt chloride and desferrioxamine were both shown to induce HIF in brain 24 h later, and to protect the neonatal brain against hypoxia-ischemia. Thus, HIF and its target genes may mediate hypoxia-induced tolerance to ischemia in neonatal brain.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bergeron M, Ferriero DM, Vreman HJ, Stevenson DK, Sharp FR (1997) Hypoxia-ischemia, but not hypoxia alone, induces the expression of heme oxygenase-1 (HSP32) in newborn rat brain. J Cereb Blood Flow Metab 17: 647 – 658
Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. (1999) Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischemia in rat brain. Eur J Neurosci 11: 4159 – 4170
Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR. (2000) Role of hypoxia inducible factor-1 (HIF-1) in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 48: 285 – 296
Chen, Graham SH, Zhu RL, Simon RP (1996) Stress proteins and tolerance to focal cerebral ischemia. J Cereb Blood Flow Metab 16: 566 – 577
Ebert BL, Firth JD, Ratcliffe PJ (1995) Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 270: 29083 – 29089
Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y (1997) A novel bHLH- PAS factor with close sequence similarity to hypoxia-inducible factor 1 alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 94: 4273 – 4278
Gidday JM, Fitzgibbons JC, Shah AR, Park TS (1994) Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat. Neurosci Lett 168: 221 – 224
Gidday JM, Shah AR, Maceren RG, Wang Q, Pelligrino DA, Holtzman DM, Park TS (1999) Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning. J Cereb Blood Flow Metab 19: 331 – 340
Goldberg MA, Dunning SP, Bunn HF (1988) Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242: 1412 – 1415
Kobayashi S, Harris VA, Welsh FA (1995) Spreading depression induces tolerance of cortical neurons to ischemia in rat brain. J Cereb Blood Flow Metab 15: 721 – 727
Semenza GL (1999) Perspectives on oxygen sensing. Cell 98: 281 – 284
Semenza GL (2000) Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol 59: 47 – 53
Wang GL, Semenza GL (1996) Molecular basis of hypoxia-induced erythropoietin expression. Curr Opin Hematol 3: 156 – 162
Whalen WJ, Ganfield R, Nair P (1970) Effects of breathing 02 or 02+C02 and of the injection of neurohumors on the p02 of cat cerebral cortex. Stroke 1: 194 – 200
Rights and permissions
Copyright information
© 2001 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sharp, F.R., Bergeron, M., Gidday, G., Yu, A.Y., Bernaudin, M., Semenza, G.L. (2001). Induction of Hypoxia-Inducible Factor-1 (HIF-1) in Adult and Neonatal Rat Brain: Possible Relationship to Hypoxia-induced Tolerance to Ischemia. In: Maturation Phenomenon in Cerebral Ischemia IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59446-5_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-59446-5_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-41107-9
Online ISBN: 978-3-642-59446-5
eBook Packages: Springer Book Archive