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Thrombolysis in Acute Stroke

  • Conference paper
Maturation Phenomenon in Cerebral Ischemia IV

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Summary

Accumulated data on use of recombinant tissue plasminogen activator in acute stroke support the efficacy and the cost effectiveness of the treatment, provided that it is carried out in selected individuals within 3 h of stroke onset, and in centers with adequate organization and experience in acute stroke management. The efficacy does, in fact, counterbalance contraindications such as potentially harmful hemorrhagic side effects. At present there is not “evidence based” recommendation of thrombolysis as routine treatment for ischemic stroke after 3 hof stroke onset. However, the results of ECASS II, and the recent meta-analyses of all three major recombinant tissue plasminogen activator (rt-PA) trials, seem to suggest that with strict selection criteria, expert CT-reading, adherence to the protocol and a stroke unit type of approach, the time window may be as long as 6 h in selected patients.

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Authors
  1. C. Fieschi
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  2. F. Orzi
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  3. D. Toni
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© 2001 Springer-Verlag Berlin Heidelberg

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Fieschi, C., Orzi, F., Toni, D. (2001). Thrombolysis in Acute Stroke. In: Maturation Phenomenon in Cerebral Ischemia IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59446-5_24

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  • DOI: https://doi.org/10.1007/978-3-642-59446-5_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41107-9

  • Online ISBN: 978-3-642-59446-5

  • eBook Packages: Springer Book Archive

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