Advertisement

UV Protection and Skin Cancer

  • Reinhard Dummer
  • Tanja Maier
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 160)

Abstract

In discussions amongst the public and the scientific community, doubts are repeatedly raised concerning the efficacy of sunscreens in preventing cutaneous malignancy. This article summarizes the most reliable references on UV protection and epithelial skin cancer and discusses the role of UV protection in melanoma prevention. We conclude that there is substantial evidence that UV protection is able to reduce the risk of actinic keratosis, squamous cell carcinoma and probably also the risk of melanoma.

Keywords

Basal Cell Carcinoma Actinic Keratosis Pyrimidine Dimer Melanocytic Nevus Mous Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Applegate LA, Scaletta C, Panizzon R, Niggli H, Frenk E (1999) In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication? Int J Mol Med 3:467–472.PubMedGoogle Scholar
  2. Autier P, Dor JF, Ng S, Linard D, Panizzon R, Lejeune FJ, Guggisberg D, Eggermont AM (1999) Sunscreen use and duration of sun exposure: a double-blind, randomized trial (see comments). J Natl Cancer Inst 91:1304–1309.PubMedCrossRefGoogle Scholar
  3. Boni R, Dummer R, Burg G (1995) Nehmen Hauttumoren zu? Schweiz Med Wochenschr 125:1619–1624.PubMedGoogle Scholar
  4. Burren, R, Scaletta C, Frenk E, Panizzon RG, Applegate LA (1998) Sunlight and carcinogenesis: expression of p53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiations. Int J Cancer 76:201–206.PubMedCrossRefGoogle Scholar
  5. Dummer R, Osterwalder U (2000) UV transmission of summer clothing in Switzerland and Germany (letter). Dermatology 200:81–82.PubMedCrossRefGoogle Scholar
  6. Dummer R, Maier T, Bloch PH, Burg G (2001) Photoprotektion: Lichtschutzmaßnahmen zum Schutz vor akuten und chronischen Hautschaden. Swiss Med Forum 14:364–368.Google Scholar
  7. Eller MS, Ostrom K, Gilchrest BA (1996) DNA damage enhances melanogenesis. Proc Natl Acad Sci USA 93:1087–1092.PubMedCrossRefGoogle Scholar
  8. Eller MS, Maeda T, Magnoni C, Atwal D, Gilchrest BA (1997) Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response. Proc Natl Acad Sci USA 94:12627–12632.PubMedCrossRefGoogle Scholar
  9. Frei T, Dummer R, Gehrig R (1999) Die UV-Belastung in der Schweiz: Abhangigkeit von Ort und Zeit und ihre Bedeutung für die Haut. Praxis 88:1023–102.PubMedGoogle Scholar
  10. Gallagher RP, Rivers JK, Lee TK, Bajdik CD, McLean DI, Coldman AJ (2000) Broad-spec- trum sunscreen use and the development of new nevi in white children: a randomized controlled trial. JAMA 283:2955–2960.PubMedCrossRefGoogle Scholar
  11. Garland CF, Garland FC, Gorham ED (1993) Rising trends in melanoma. An hypothesis concerning sunscreen effectiveness (see comments). Ann Epidemiol 3:103–110.PubMedCrossRefGoogle Scholar
  12. Gilchrest BA, Eller MS, Geller AC, Yaar M (1999) The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 340:1341–1348.PubMedCrossRefGoogle Scholar
  13. Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, Marks GC, Gaffney P, Battistutta D, Frost C, Lang C, Russell A (1999) Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial (see comments). Lancet 354:723–729.PubMedCrossRefGoogle Scholar
  14. Ley RD (1997) Ultraviolet radiation A-induced precursors of cutaneous melanoma in Mono- delphis domestica. Cancer Res 57:3682–3684.PubMedGoogle Scholar
  15. Lim HW, Naylor M,Honigsmann H, Gilchrest BA, Cooper K, Morison W, Deleo VA, Scherschun L (2001) American Academy of Dermatology Consensus Conference on UVA Protection of Sunscreens: summary and recommendations. Washington, DC, 4 February 2000. J Am Acad Dermatol 44:505–508Google Scholar
  16. Naylor MF (1997) Erythema, skin cancer risk, and sunscreens. Arch Dermatol 133:373–375.PubMedCrossRefGoogle Scholar
  17. Naylor MF, Boyd A, Smith DW, Cameron GS, Hubbard D, Neldner KH (1995) High sun pro-tection factor sunscreens in the suppression of actinic neoplasia. Arch Dermatol 131:170–175.PubMedCrossRefGoogle Scholar
  18. Rigel DS, Naylor M, Robinson J (2000) What is the evidence for a sunscreen and melanoma controversy Arch Dermatol 136:1447–1449.PubMedCrossRefGoogle Scholar
  19. Setlow RB, Grist E, Thompson K, Woodhead AD (1993) Wavelengths effective in induction of malignant melanoma. Proc Natl Acad Sci USA 90:6666–6670.PubMedCrossRefGoogle Scholar
  20. Thompson SC, Jolley D, Marks R (1993) Reduction of solar keratoses by regular sunscreen use (see comments). N Engl J Med 329:1147–1151.PubMedCrossRefGoogle Scholar
  21. Wang SQ, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS (2001) Ultraviolet A and melanoma: a review. J Am Acad Dermatol 44:837–846.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Reinhard Dummer
  • Tanja Maier

There are no affiliations available

Personalised recommendations