Advertisement

The Precursors of Malignant Melanoma

  • A. Neil Crowson
  • Cynthia M. Magro
  • Ignacio Sanchez-Carpintero
  • Martin C. MihmJr
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 160)

Abstract

The precursors to melanoma are generally considered to be related to nevi of different types. Here we emphasize the dysplastic nevus, the congenital nevus, and lentigo maligna as specific lesions. The dysplastic nevus is discussed not only as a formal precursor but also as a marker of cutaneous melanoma. The clinical and histologic characteristics are outlined, as well as evidence of progression in dysplastic nevi. The congenital nevus is briefly reviewed and emphasis is placed upon clues to malignant degeneration. The concept of lentigo maligna as a precursor as distinct from an in situ phase is detailed.

Keywords

Cytologic Atypia Melanocytic Nevus Outer Root Sheath Dysplastic Nevus Vertical Growth Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Crowson AN, Magro CM, Mihm MC Jr (2001) The melanocytic proliferations: a comprehensive textbook of pigmented lesions. Wiley-Liss, New York, pp 209–223, 225–280, 282–447, 162–175.Google Scholar
  2. 2.
    Lynch HT, Frichot B, Lynch JF (1978) Familial atypical multi-mole melanoma syndroms J Med Genet 15:352–356.PubMedCrossRefGoogle Scholar
  3. 3.
    Clark WB, Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ (1978) Origin of familial malignant melanomas from heritable melanocytic lesions. “The B-K mole syndrome”. Arch Dermatol 114:732–738.PubMedCrossRefGoogle Scholar
  4. 4.
    Shea CR, Vollmer RT, Prieto VG (1999) Correlating architectural disorder and cytologic atypia in Clark (dysplastic) melanocytic nevi. Hum Pathol 30:500–505.PubMedCrossRefGoogle Scholar
  5. 5.
    Nordlund JJ, Kirkwood J, Forget BM, et al. (1985) Demographic study of clinically atypical (dysplastic) nevi in patients with melanoma and comparison subjects. Cancer Res 45:1855–1861.PubMedGoogle Scholar
  6. 6.
    Grob JJ, Andrac L, Romano MH, et al. (1988) Dysplastic naevus in non-familial melanoma. A clinicopathological study of 101 cases. Br J Dermatol 118:745–752.PubMedCrossRefGoogle Scholar
  7. 7.
    Cannon-Albright LA, Meyer LJ, Lewis CM, et al. (1994) Penetrance and expressivity of the chromosome 9p melanoma susceptibility locus (MLM). Cancer Res 54:6041–6044.PubMedGoogle Scholar
  8. 8.
    Greene MH, Clark WH, Tucker MA, Kraemer KH, Elder DE, Fraser MC (1985) High risk of malignant melanoma in melanoma-prone families with dysplastic nevi. Ann Intern Med 102:458–465.PubMedGoogle Scholar
  9. 9.
    Park WS, Vortmeyer AO, Pack S, et al. (1998) Allelic deletion at chromosome 9p21(pl6) and 17pl3(p53) in microdissected sporadic dysplastic nevus. Hum Pathol 29:127–130.PubMedCrossRefGoogle Scholar
  10. 10.
    Birindelli S, Tragni G, Bartoli C, et al. (2000) Detection of microsatellite alterations in the spectrum of melanocytic nevi in patients with or without individual or family history of melanoma. Int J Cancer 86:255–261.PubMedCrossRefGoogle Scholar
  11. 11.
    Vasen HF, Gruis NA, Frants RR, van der Velden PA, Hille ET, Bergman W (2000) Risk of developing pancreatic cancer in families associated with a specific 19 bp deletion of pl6 (pl6-Leiden). Int J Cancer 87:809–811.PubMedCrossRefGoogle Scholar
  12. 12.
    Mcintosh LM, Summers R, Jackson M, et al. (2001) Towards non-invasive screening of skin lesions by near-infrared spectroscopy. J Invest Dermatol 116:175–181.PubMedCrossRefGoogle Scholar
  13. 13.
    Clemente C, Cochran A J, Elder DE, et al. (1991) Histopathologic diagnosis of dysplastic nevi: concordance among pathologists convened by the World Health Organization Melanoma Programme. Hum Pathol 22:313–319.PubMedCrossRefGoogle Scholar
  14. 14.
    Toussaint S, Kamino H (1999) Dysplastic changes in different types of melanocytic nevi. A unifying concept J Cutan Pathol 26:84–90.PubMedCrossRefGoogle Scholar
  15. 15.
    Murphy G, Mihm MC Jr (1999) Recognition and evaluation of cytological dysplasia in acquired melanocytic nevi. Hum Pathol 30:506–512.PubMedCrossRefGoogle Scholar
  16. 16.
    Hastrup N, Clemmensen OJ, Spaun E, Sondergaard K (1994) Dysplastic naevus: histopathologic criteria and their inter-observer reproducibility. Histopathology 24:503–509.PubMedCrossRefGoogle Scholar
  17. 17.
    Clark WH, Mihm MC (1969) Lentigo maligna and lentigo maligna melanoma. Am J Pathol 55:39–54.PubMedGoogle Scholar
  18. 18.
    Tannous ZS, Lerner LH, Duncan LM, Mihm MC Jr, Flotte TJ (2000) Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type. Hum Pathol 31:705–708.PubMedCrossRefGoogle Scholar
  19. 19.
    Weinstock MA, Sober AJ (1987) The risk of progression of lentigo maligna to lentigo maligna melanoma. Br J Dermatol 116:303–310.PubMedCrossRefGoogle Scholar
  20. 20.
    Grammatico P, Modesti A, Steindl K, et al. (1992) Lentigo maligna: cytogenetic, ultra- structural, and phenotypic characterization of a primary cell culture. Cancer Genet Cy- togenet 60:141–146.CrossRefGoogle Scholar
  21. 21.
    Koh HK, Michalik E, Sober AJ, et al. (1984) Lentigo maligna melanoma has no better prognosis than other types of melanoma. J Clin Oncol 2:994–1001.PubMedGoogle Scholar
  22. 22.
    Cohen LM (1995) Lentigo maligna and lentigo maligna melanoma. J Am Acad Dermatol 33:923–936.PubMedCrossRefGoogle Scholar
  23. 23.
    Bittencourt FV, Marghoob AA, Kopf AW, Koenig KL, Bart RS (2000) Large congenital melanocytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis. Pediatrics 106:736–741.PubMedCrossRefGoogle Scholar
  24. 24.
    Swerdlow AJ, English JS, Qiao Z (1995) The risk of melanoma in patients with congenital nevi: a cohort study. J Am Acad Dermatol 32:595–599.PubMedCrossRefGoogle Scholar
  25. 25.
    Lowes MA, Norris D, Whiteld M (2000) Benign melanocytic proliferative nodule within a congenital naevus. Austr J Dermatol 41:109–111.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • A. Neil Crowson
  • Cynthia M. Magro
  • Ignacio Sanchez-Carpintero
  • Martin C. MihmJr

There are no affiliations available

Personalised recommendations