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Alpha-2-Macroglobulin Level regulates the Anticoagulant Cofactor Activity of Protein S in Cord and Adult Plasma

  • Conference paper
31st Hemophilia Symposium Hamburg 2000

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Abstract

Alpha2-macroglobulin (a2-M) is a broad spectrum protease binding protein. It is known to bind i.e. α-thrombin (1), and activated protein C (APC) (2). The proteinases are physically trapped and thus their active sites are excluded from natural substrates. It has been suggested that a2-M may provide protection from thromboembolic events in antithrombin (AT) deficient children due to complex formation with free α-thrombin (3).

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Authors
  1. G. Cvirn
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  2. S. Gallistl
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  3. M. Köstenberger
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  4. J. Kutschera
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  5. B. Leschnik
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  6. W. Muntean
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Editor information

Editors and Affiliations

  1. Hemophilia Center, Dept. of Internal Medicine, University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    Inge Scharrer

  2. Dept. of Hemostasiology, University Hospital, Ziemssenstr. 1a, D-80336, München, Germany

    Wolfgang Schramm

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© 2002 Springer-Verlag Berlin Heidelberg

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Cvirn, G., Gallistl, S., Köstenberger, M., Kutschera, J., Leschnik, B., Muntean, W. (2002). Alpha-2-Macroglobulin Level regulates the Anticoagulant Cofactor Activity of Protein S in Cord and Adult Plasma. In: Scharrer, I., Schramm, W. (eds) 31st Hemophilia Symposium Hamburg 2000. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59383-3_39

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  • DOI: https://doi.org/10.1007/978-3-642-59383-3_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42131-3

  • Online ISBN: 978-3-642-59383-3

  • eBook Packages: Springer Book Archive

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