Zusammenfassung
Myoglobin im Urin weist auf eine schwere Muskelschädigung hin, deren morphologisches Substrat in der Regel aus mehr oder weniger zahlreichen segmentalen oder ausgedehnteren Einzelfasernekrosen (Rhabdomyolyse) besteht. Das Myoglobin (MG 17000) ist normalerweise in der I-Band-Region lokalisiert, kann aber unter pathologischen Bedingungen auch im erweiterten Lumen des inneren Membransystems und frei im Sarkoplasma zu finden sein (Kawai et al. 1991). Von dort wird es in den extrazellulären Raum abgegeben und als relativ kleines Molekül gut durch die Niere ausgeschieden; doch können übergroße Mengen an Myoglobin zu einer tubulären Insuffizienz führen.
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Schröder, J.M. (2002). Myoglobinurien, Myositis ossificans, nutritiv-toxische und paraneoplatische Myopathien, Amyloidosen. In: Peiffer, J., Schröder, J.M., Paulus, W. (eds) Neuropathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59371-0_37
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