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Lipoprotein Genes and Diet in the Evolution of Human Intelligence and Longevity

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Brain and Longevity

Part of the book series: Research and Perspectives in Longevity ((RPL))

Summary

Humans have evolved two traits that differ from other great apes and that appear to be antagonistic: slower aging despite a major increase in meat eating. The three great apes - chimpanzees, gorillas, and orangutans - and the gibbons do not live more than 60 years under the best circumstances. The longevity of humans evolved despite the higher exposure to cholesterol and other fats than in other great apes. Laboratory chimpanzees are highly sensitive to dietary fat, which causes hyperlipidemia, accelerated vascular disease, and rapid increases in myocardial infarcts. Furthermore, clinical and animal studies indicate that blood cholesterol is a risk factor in Alzheimer Disease. We conclude that the evolution of “meat-adaptive genes” was crucial to the evolution of human longevity.

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  1. C. E. Finch
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  2. C. B. Stanford
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Editors and Affiliations

  1. Ethel Percy Aandrus Gerontology Center, Division of Neurogerontology, University Park MC-0191, Mc Clintok, 3715, 90089-0191, Los Angeles, CA, USA

    Caleb E. Finch

  2. INSERM, Equipe Demographie et Sante Centre Val d’aurelle Parc Euromedecine, 34298, Montpellier cedex, France

    Jean-Marie Robine

  3. Pour la Recherche Therapeutique, Fondation IPSEN, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen Ph.D.

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Finch, C.E., Stanford, C.B. (2003). Lipoprotein Genes and Diet in the Evolution of Human Intelligence and Longevity. In: Finch, C.E., Robine, JM., Christen, Y. (eds) Brain and Longevity. Research and Perspectives in Longevity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59356-7_3

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