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Hereditäre Immundefizienzen und hämatologische Neoplasien

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Molekularmedizinische Grundlagen von hämatologischen Neoplasien

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Zu primären Immundefizienzen (ID) kommt es, wenn eine oder mehrere Komponenten des Immunsystems defekt sind. In den hoch industrialisierten Ländern sind die meisten ID erblich bedingt. Patienten oder Patientinnen mit einer erblichen ID fallen klinisch durch rezidivierende Infekte im Kindesalter auf. Während rezidivierende Infektionen durch pyogene Bakterien auf einen Defekt der Antikörper-, der Komplement- oder der Phagozytenfunktion hinweisen, werden virale Infektionen hauptsächlich durch die Dysregulation T-Zell-vemittelter Immunantworten verursacht.

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Authors
  1. Alfons Meindl
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  1. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Intitut für Zell- und Molekularpathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30623, Hannover, Deutschland

    Brigitte Schlegelberger

  3. Medizinische Fakultät, Institut für Medizinische Biologie, Universität Wien, Währinger Gürtel 10, A-1090, Wien IX, Österreich

    Christa Fonatsch

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Meindl, A. (2003). Hereditäre Immundefizienzen und hämatologische Neoplasien. In: Ganten, D., Ruckpaul, K., Schlegelberger, B., Fonatsch, C. (eds) Molekularmedizinische Grundlagen von hämatologischen Neoplasien. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59343-7_2

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