Assessing the role of quantitative analysis of mammograms in describing breast density changes in women using HRT
We present an update of our investigations into the potential role of quantitative measures of breast density for characterising breast changes, and, in particular, changes due to Hormone Replacement Therapy (HRT). It has been established that long-term use of HRT can increase the risk of breast cancer, a fact that enforces the belief that objective measures of tissue density can be an important development in breast cancer image analysis. A set of 59 mammogram temporal HRT sequences (2 images per patient) were used in our experiments. The clinician’s assessment of density changes constituted the ground truth for evaluating the proposed quantitative measures of density change. The measures are based on the h int representation of interesting tissue and their performance (agreement with the expert’s description) is also compared to the “interactive thresholding” method that has been used in the past to characterise mammographic density.
KeywordsBreast Cancer Breast Cancer Risk Hormone Replacement Therapy Mammographic Density Breast Density
Unable to display preview. Download preview PDF.
- 1.Collaborative Group on Hormonal Factors in Breast Cancer.: Breast cancer and hormone replacement therapy: collaborative analysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer. The Lancet 350 (No. 9084) (1997) 1047–1059CrossRefGoogle Scholar
- 2.Jameson, J.L. (ed.): Principles of Molecular Medicine. Humana Press Inc. New Jersey USAGoogle Scholar
- 4.Boyd, N.F, Lockwood, G.A, Byng J.W. et al.: Mammographie densities and breast cancer risk. Cancer Epidimiol Biomarkers. 7 (1998) 1133–1144Google Scholar
- 5.Highnam, R.P., Brady, J.M.: Mammographie image processing. Kluwer Academic Press (1999)Google Scholar