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Assessing the role of quantitative analysis of mammograms in describing breast density changes in women using HRT

  • Kostas Marias
  • Ralph Highnam
  • Michael Brady
  • Santilal Parbhoob
  • Alexander Seifalian

Abstract

We present an update of our investigations into the potential role of quantitative measures of breast density for characterising breast changes, and, in particular, changes due to Hormone Replacement Therapy (HRT). It has been established that long-term use of HRT can increase the risk of breast cancer, a fact that enforces the belief that objective measures of tissue density can be an important development in breast cancer image analysis. A set of 59 mammogram temporal HRT sequences (2 images per patient) were used in our experiments. The clinician’s assessment of density changes constituted the ground truth for evaluating the proposed quantitative measures of density change. The measures are based on the h int representation of interesting tissue and their performance (agreement with the expert’s description) is also compared to the “interactive thresholding” method that has been used in the past to characterise mammographic density.

Keywords

Breast Cancer Breast Cancer Risk Hormone Replacement Therapy Mammographic Density Breast Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Kostas Marias
    • 1
  • Ralph Highnam
    • 2
  • Michael Brady
    • 1
  • Santilal Parbhoob
    • 3
  • Alexander Seifalian
    • 3
  1. 1.Robotics Research Group, Engineering ScienceOxford UniversitySummertown, OxfordUK
  2. 2.MIRADA SOLUTIONS LimitedOxford Centre for InnovationUSA
  3. 3.Department of SurgeryRoyal Free and University College Medical School, UCLLondonUK

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